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Biology and Biochemistry

D-Index
68
Citations
15496
World Ranking
7841
National Ranking
28

Overview

Muthu K. Shanmugam is affiliated with the National University of Singapore in Singapore. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Oncology, Organic Chemistry, Pathology and Forensic Medicine, and Cancer Research.

Their scientific work often centers on topics such as Cytokine Signaling Pathways and Interactions, Synthesis and biological activity, Natural product bioactivities and synthesis, Epigenetics and DNA Methylation, Sirtuins and Resveratrol in Medicine, Tea Polyphenols and Effects, and Cancer Cells and Metastasis.

Key recent publications include:

  • "Resveratrol for cancer therapy: Challenges and future perspectives," 2021, Cancer Letters
  • "Mechanism of epithelial-mesenchymal transition in cancer and its regulation by natural compounds," 2023, Medicinal Research Reviews
  • "The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy," 2020, Medicinal Research Reviews
  • "Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition," 2025, Journal of Hematology & Oncology
  • "Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway," 2020, Biochimie

Frequent co-authors who have collaborated with Shanmugam include Gautam Sethi, Kanchugarakoppal S. Rangappa, Chakrabhavi Dhananjaya Mohan, Alan Prem Kumar, and Arunachalam Chinnathambi.

The venues in which Shanmugam most commonly publishes include:

  • Cancer Research
  • Medicinal Research Reviews
  • Bioorganic & Medicinal Chemistry Letters
  • Cancer Letters
  • Journal of Hematology & Oncology

The scope of Shanmugam's research reflects an interdisciplinary approach combining detailed molecular studies with practical therapeutic insights, particularly around cancer biology, the tumor microenvironment, and natural compound-based interventions.

Best Publications

  • The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges.

    Chin-Yap Loh;Jian Yi Chai;Ting Fang Tang;Won Fen Wong

  • The Role of Resveratrol in Cancer Therapy

    Jeong-Hyeon Ko;Gautam Sethi;Jae-Young Um;Muthu K Shanmugam

  • The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

    Muthu K. Shanmugam;Grishma Rane;Madhu Mathi Kanchi;Frank Arfuso

  • Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

    Radhamani Kannaiyan;Muthu K. Shanmugam;Gautam Sethi

  • Ageing and the telomere connection: An intimate relationship with inflammation.

    Jingwen Zhang;Grishma Rane;Xiaoyun Dai;Muthu K. Shanmugam

  • Multifaceted link between cancer and inflammation

    Gautam Sethi;Muthu K. Shanmugam;Lalitha Ramachandran;Alan Prem Kumar

  • Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

    Muthu K. Shanmugam;Xiaoyun Dai;Alan Prem Kumar;Benny K.H. Tan

  • Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.

    Aruljothi Subramaniam;Muthu K. Shanmugam;Ekambaram Perumal;Feng Li

  • Targeting autophagy using natural compounds for cancer prevention and therapy

    Shuo Deng;Muthu K. Shanmugam;Alan Prem Kumar;Celestial T. Yap;Celestial T. Yap

  • Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

    Muthu K. Shanmugam;Radhamani Kannaiyan;Gautam Sethi

  • Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

    Deepti Shrimali;Muthu K. Shanmugam;Alan Prem Kumar;Jingwen Zhang

  • Resveratrol for cancer therapy: Challenges and future perspectives.

    Boxu Ren;Marabeth Xin-Yi Kwah;Cuiliu Liu;Zhaowu Ma

  • Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence

    Muthu K. Shanmugam;Xiaoyun Dai;Alan Prem Kumar;Benny K.H. Tan

  • Targeting transcription factor STAT3 for cancer prevention and therapy.

    Edna Zhi Pei Chai;Muthu K. Shanmugam;Frank Arfuso;Arunasalam Dharmarajan

  • Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer.

    Muthu K. Shanmugam;An H. Nguyen;Alan Prem Kumar;Alan Prem Kumar;Benny K-H Tan

  • Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

    Muthu K Shanmugam;Jong Hyun Lee;Edna Zhi Pei Chai;Madhu Mathi Kanchi

  • Analysis of the Intricate Relationship Between Chronic Inflammation and Cancer

    Edna Zhi Pei Chai;Kodappully Sivaraman Siveen;Muthu K. Shanmugam;Frank Arfuso

  • Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

    Gautam Sethi;Muthu K. Shanmugam;Sudha Warrier;Myriam Merarchi

  • Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

    Peramaiyan Rajendran;Feng Li;Muthu K. Shanmugam;Shireen Vali

  • Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

    Muthu K. Shanmugam;Sudha Warrier;Alan Prem Kumar;Gautam Sethi

Frequent Co-Authors

Gautam Sethi
Gautam Sethi National University of Singapore
Alan Prem Kumar
Alan Prem Kumar National University of Singapore
Kwang Seok Ahn
Kwang Seok Ahn Kyung Hee University
Feng Li
Feng Li Shandong University
Frank Arfuso
Frank Arfuso University of Western Australia
Kam M. Hui
Kam M. Hui National Cancer Centre Singapore
Kanchugarakoppal S. Rangappa
Kanchugarakoppal S. Rangappa University of Mysore
Anupam Bishayee
Anupam Bishayee Lake Erie College of Osteopathic Medicine
Tapas K. Kundu
Tapas K. Kundu Jawaharlal Nehru Centre for Advanced Scientific Research
Vinay Tergaonkar
Vinay Tergaonkar Agency for Science, Technology and Research

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