World's Best Scientists 2026 revealed!
Bradley E. Bernstein

Bradley E. Bernstein

Award Badge
Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Genetics

D-Index
126
Citations
151659
World Ranking
295
National Ranking
155

Medicine

D-Index
127
Citations
152366
World Ranking
2747
National Ranking
1535

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2016 - National Institutes of Health Director's Pioneer Award
  • 2015 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

The scientist’s investigation covers issues in Genetics, Chromatin, Epigenetics, Computational biology and Human genome. His study in Genome, Epigenomics, DNA methylation, Histone and Histone code falls within the category of Genetics. The study incorporates disciplines such as Polycomb-group proteins and Induced pluripotent stem cell in addition to Chromatin.

The concepts of his Epigenetics study are interwoven with issues in Transcription factor, Regulation of gene expression, Gene expression profiling and Cancer research. He has researched Computational biology in several fields, including Transcriptional noise, ENCODE and Peak calling. Within one scientific family, Bradley E. Bernstein focuses on topics pertaining to Epigenome under Human genome, and may sometimes address concerns connected to Epigenesis.

His most cited work include:

  • Model-based Analysis of ChIP-Seq (MACS) (8233 citations)
  • Model-based Analysis of ChIP-Seq (MACS) (8233 citations)
  • Comprehensive mapping of long-range interactions reveals folding principles of the human genome. (4920 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Chromatin, Genetics, Computational biology, Epigenetics and Cancer research. The various areas that Bradley E. Bernstein examines in his Chromatin study include Enhancer, Transcription factor, Histone and Cell biology. His study in Epigenomics, Regulation of gene expression, Gene, Histone code and Chromatin immunoprecipitation is carried out as part of his studies in Genetics.

The Computational biology study combines topics in areas such as Genome, Human genome, Genomics, DNA and ChIP-sequencing. His Epigenetics study deals with DNA methylation intersecting with CTCF. His study focuses on the intersection of Cancer research and fields such as Cell with connections in the field of RNA, RNA-Seq, Immune system and Oligodendroglioma.

He most often published in these fields:

  • Chromatin (84.29%)
  • Genetics (82.98%)
  • Computational biology (58.38%)

What were the highlights of his more recent work (between 2017-2021)?

  • Computational biology (58.38%)
  • Epigenetics (57.33%)
  • Cancer research (37.96%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Computational biology, Epigenetics, Cancer research, Chromatin and DNA methylation. His biological study spans a wide range of topics, including Cell and Genome, Gene, Cas9, ENCODE. He has included themes like Protein kinase B, Enhancer, Receptor tyrosine kinase, Genetic heterogeneity and PDGFRA in his Epigenetics study.

His Cancer research study combines topics from a wide range of disciplines, such as Carcinogenesis, Cancer, Wnt signaling pathway, Transcription factor and Druggability. Bradley E. Bernstein combines subjects such as Epigenome, Epigenomics, Histone and Cell biology with his study of Chromatin. His DNA methylation course of study focuses on CTCF and GiST.

Between 2017 and 2021, his most popular works were:

  • Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (362 citations)
  • Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (362 citations)
  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma (341 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

Cancer research, Computational biology, Regulation of gene expression, Gene and Epigenetics are his primary areas of study. Bradley E. Bernstein focuses mostly in the field of Cancer research, narrowing it down to topics relating to Cell and, in certain cases, RNA, Genotyping and Bone marrow. His work in Computational biology addresses subjects such as Epigenomics, which are connected to disciplines such as Genome regulation, ENCODE and Genome.

As part of one scientific family, Bradley E. Bernstein deals mainly with the area of Regulation of gene expression, narrowing it down to issues related to the Transcriptome, and often Wnt signaling pathway, Medulloblastoma, Genomics and Single-cell analysis. His Gene research is within the category of Genetics. His Epigenetics research is multidisciplinary, incorporating elements of CTCF, Oncogene, GiST and Kit oncogene.

Best Publications

  • Model-based Analysis of ChIP-Seq (MACS)

    Yong Zhang;Tao Liu;Clifford A Meyer;Jérôme Eeckhoute

  • Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

    Erez Lieberman-Aiden;Nynke L. van Berkum;Louise Williams;Maxim Imakaev

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

    Bradley E. Bernstein;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Xiaohui Xie;Michael Kamal

  • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

    Tarjei S. Mikkelsen;Manching Ku;Manching Ku;David B. Jaffe;Biju Issac;Biju Issac

  • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

    Mitchell Guttman;Ido Amit;Manuel Garber;Courtney French

  • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

    Anoop Premswaroop Patel;I. Tirosh;J. J. Trombetta;Alexander Kann Shalek

  • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

    Marius Wernig;Alexander Meissner;Ruth Foreman;Tobias Brambrink

  • Mapping and analysis of chromatin state dynamics in nine human cell types

    Jason Ernst;Pouya Kheradpour;Pouya Kheradpour;Tarjei S. Mikkelsen;Noam Shoresh

  • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

    Ahmad M. Khalil;Mitchell Guttman;Maite Huarte;Manuel Garber

  • Genome-scale DNA methylation maps of pluripotent and differentiated cells

    Alexander Meissner;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Hongcang Gu;Marius Wernig

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • The mammalian epigenome.

    Bradley E. Bernstein;Bradley E. Bernstein;Alexander Meissner;Eric S. Lander;Eric S. Lander

  • Active genes are tri-methylated at K4 of histone H3

    Helena Santos-Rosa;Robert Schneider;Andrew J. Bannister;Julia Sherriff

  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

    Stephen G. Landt;Georgi K. Marinov;Anshul Kundaje;Pouya Kheradpour

  • Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

    Kyle Kai How Farh;Alexander Marson;Jiang Zhu;Markus Kleinewietfeld

  • Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

    Sidharth V. Puram;Itay Tirosh;Itay Tirosh;Anuraag S. Parikh;Anoop P. Patel

  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Cyril Neftel;Julie Laffy;Mariella G. Filbin;Toshiro Hara

  • The NIH Roadmap Epigenomics Mapping Consortium

    Bradley E Bernstein;John A Stamatoyannopoulos;Joseph F Costello;Bing Ren

  • Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

    Bradley E. Bernstein;Bradley E. Bernstein;Bradley E. Bernstein;Michael Kamal;Kerstin Lindblad-Toh;Stefan Bekiranov

Frequent Co-Authors

Aviv Regev
Aviv Regev Genentech
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Eric S. Lander
Eric S. Lander Broad Institute
Tarjei S. Mikkelsen
Tarjei S. Mikkelsen Arsenal Biosciences (United States)
Jon C. Aster
Jon C. Aster Harvard Medical School
Itay Tirosh
Itay Tirosh Weizmann Institute of Science
David N. Louis
David N. Louis Harvard University
Todd R. Golub
Todd R. Golub Harvard University
Miguel Rivera
Miguel Rivera Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Genetics can open doors to a diverse range of online programs and career pathways in healthcare, biotechnology, and research. Many students with a genetics background choose to complement their expertise with specialized nursing or healthcare degrees that expand their career options in clinical settings or advanced practice roles.

For those interested in blending genetics with direct patient care, affordable fnp programs offer a cost-effective path to becoming a family nurse practitioner. Similarly, earning a bachelor's degree through rn to bsn online programs can help registered nurses deepen their knowledge and prepare for specialized roles, including those focused on genetic counseling and testing.

If you’re seeking the most value from your education investment, there are most affordable nursing programs available online, making it easier to enter or advance within the healthcare field. For advanced practitioners aiming for leadership and research roles, msn to dnp programs are available remotely for greater flexibility, offering a terminal degree that enhances opportunities in genetics and related specialties.

Best Scientists Citing Bradley E. Bernstein

Trending Scientists