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Manolis Kellis

Manolis Kellis

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Genetics
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Genetics

D-Index
148
Citations
161592
World Ranking
143
National Ranking
75

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2008 - Fellow of Alfred P. Sloan Foundation

Overview

Manolis Kellis is a researcher affiliated with MIT in the United States, specializing in multiple subfields of biology. Their research spans molecular biology, genetics, immunology, neurology, and physiology, with a significant focus on gene regulation and cellular mechanisms.

The scientist's work covers several key topics including single-cell and spatial transcriptomics, neuroinflammation and neurodegeneration mechanisms, RNA modifications and cancer, RNA research and splicing, RNA and protein synthesis mechanisms, epigenetics and DNA methylation, and genomics and chromatin dynamics.

Manolis Kellis has contributed extensively to the scientific literature, with frequent publications in notable venues such as ENCODE Datasets, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature, and Cell.

Recent papers authored or co-authored by Kellis include:

  • The GTEx Consortium atlas of genetic regulatory effects across human tissues (2020, Science)
  • GENCODE 2021 (2020, Nucleic Acids Research)
  • The impact of sex on gene expression across human tissues (2020, Science)
  • Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (2020, Nature)
  • GENCODE: reference annotation for the human and mouse genomes in 2023 (2022, Nucleic Acids Research)

Key frequent co-authors include:

  • Li-Huei Tsai
  • Irwin Jungreis
  • Carles A. Boix
  • José Dávila-Velderrain
  • Jiekun Yang

In 2008, Manolis Kellis was recognized as a Fellow of the Alfred P. Sloan Foundation.

Best Publications

  • The Genotype-Tissue Expression (GTEx) project

    John Lonsdale;Jeffrey Thomas;Mike Salvatore;Rebecca Phillips

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

    Kristin G. Ardlie;David S. Deluca;Ayellet V. Segrè

  • The GTEx Consortium atlas of genetic regulatory effects across human tissues

    F Aguet;AN Barbeira;R Bonazzola;A Brown

  • GENCODE: The reference human genome annotation for The ENCODE Project

    Jennifer Harrow;Adam Frankish;Jose M. Gonzalez;Electra Tapanari

  • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

    Mitchell Guttman;Ido Amit;Manuel Garber;Courtney French

  • Mapping and analysis of chromatin state dynamics in nine human cell types

    Jason Ernst;Pouya Kheradpour;Pouya Kheradpour;Tarjei S. Mikkelsen;Noam Shoresh

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Genome sequence, comparative analysis and haplotype structure of the domestic dog

    Kerstin Lindblad-Toh;Claire M Wade;Claire M Wade;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Elinor K. Karlsson;Elinor K. Karlsson

  • Histone Modifications at Human Enhancers Reflect Global Cell-Type-Specific Gene Expression

    Nathaniel D. Heintzman;Gary C. Hon;R. David Hawkins;Pouya Kheradpour

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila

    Julius Brennecke;Alexei A. Aravin;Alexander Stark;Monica Dus

  • Transcriptional regulatory code of a eukaryotic genome

    Christopher T. Harbison;D. Benjamin Gordon;Tong Ihn Lee;Nicola J. Rinaldi

  • GENCODE reference annotation for the human and mouse genomes.

    Adam Frankish;Mark Diekhans;Anne-Maud Ferreira;Rory Baldwin Johnson

  • ChromHMM: automating chromatin-state discovery and characterization

    Jason Ernst;Jason Ernst;Manolis Kellis

  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

    Stephen G. Landt;Georgi K. Marinov;Anshul Kundaje;Pouya Kheradpour

  • Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

    Xiaohui Xie;Jun Lu;E. J. Kulbokas;Todd R. Golub

  • HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

    Lucas D. Ward;Manolis Kellis

  • Evolution of genes and genomes on the Drosophila phylogeny.

    Andrew G. Clark;Michael B. Eisen;Michael B. Eisen;Douglas R. Smith;Casey M. Bergman

  • Sequencing and comparison of yeast species to identify genes and regulatory elements

    Manolis Kellis;Nick Patterson;Matthew Endrizzi;Bruce Birren

Frequent Co-Authors

Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Eric S. Lander
Eric S. Lander Broad Institute
Anshul Kundaje
Anshul Kundaje Stanford University
Alexander Stark
Alexander Stark Research Institute of Molecular Pathology
Aviv Regev
Aviv Regev Genentech
Roderic Guigó
Roderic Guigó Pompeu Fabra University
Mark Gerstein
Mark Gerstein Yale University
John A. Stamatoyannopoulos
John A. Stamatoyannopoulos University of Washington
Michael Snyder
Michael Snyder Stanford University
Philip L. De Jager
Philip L. De Jager Columbia University

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