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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
44583
World Ranking
10499
National Ranking
100

Overview

Itay Tirosh is affiliated with the Weizmann Institute of Science in Israel and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, with a strong focus on Medicine. Their work spans several subfields including Molecular Biology, Oncology, Genetics, Cancer Research, and Immunology.

The scientist's research covers a range of topics, especially centered on cancer biology and single-cell analysis techniques. Key areas of study include:

  • Single-cell and spatial transcriptomics
  • Glioma diagnosis and treatment
  • Cancer genomics and diagnostics
  • Immune cells in cancer
  • Cancer immunotherapy and biomarkers
  • Cancer cells and metastasis
  • Cell image analysis techniques

Their publication record includes multiple papers with significant citations, emphasizing contributions to understanding cancer heterogeneity, immune interactions, and tumor biology. Notable recent papers include:

  • "Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma," published in 2021 in Cancer Cell
  • "A single-cell landscape of high-grade serous ovarian cancer," published in 2020 in Nature Medicine
  • "Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity," published in 2020 in Nature Genetics
  • "Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours," published in 2023 in Nature
  • "Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis," published in 2021 in Cell

Frequent co-authors who collaborate with Itay Tirosh include:

  • Mario L. Suvà
  • Masashi Nomura
  • Lillian Bussema
  • L. Nicolas Gonzalez Castro
  • Avishay Spitzer

In terms of publication venues, their work often appears in specialized journals related to cancer and neuro-oncology as well as high-impact multidisciplinary journals, including:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cancer Cell
  • Nature

Best Publications

  • Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

    Evan Z. Macosko;Evan Z. Macosko;Anindita Basu;Anindita Basu;Rahul Satija;Rahul Satija;James Nemesh;James Nemesh

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    Itay Tirosh;Benjamin Izar;Benjamin Izar;Sanjay M. Prakadan;Marc H. Wadsworth

  • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

    Anoop Premswaroop Patel;I. Tirosh;J. J. Trombetta;Alexander Kann Shalek

  • Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

    Sidharth V. Puram;Itay Tirosh;Itay Tirosh;Anuraag S. Parikh;Anoop P. Patel

  • An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

    Cyril Neftel;Julie Laffy;Mariella G. Filbin;Toshiro Hara

  • A single-cell survey of the small intestinal epithelium

    Adam L. Haber;Moshe Biton;Moshe Biton;Noga Rogel;Rebecca H. Herbst;Rebecca H. Herbst

  • A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

    Livnat Jerby-Arnon;Parin Shah;Michael S. Cuoco;Christopher Rodman

  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh

  • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

    Itay Tirosh;Andrew S. Venteicher;Andrew S. Venteicher;Christine Hebert;Christine Hebert;Leah E. Escalante;Leah E. Escalante

  • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

    Andrew S. Venteicher;Andrew S. Venteicher;Itay Tirosh;Christine Hebert;Christine Hebert;Keren Yizhak;Keren Yizhak

  • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

    Mario Luca Suva;Mario Luca Suva;Mario Luca Suva;Esther Rheinbay;Esther Rheinbay;Esther Rheinbay;Shawn M. Gillespie;Shawn M. Gillespie;Shawn M. Gillespie;Anoop Premswaroop Patel;Anoop Premswaroop Patel

  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

    Mariella G. Filbin;Itay Tirosh;Itay Tirosh;Volker Hovestadt;Volker Hovestadt;McKenzie L. Shaw;McKenzie L. Shaw

  • Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

    Monika S. Kowalczyk;Itay Tirosh;Dirk Heckl;Tata Nageswara Rao;Tata Nageswara Rao

  • A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

    Oren Parnas;Marko Jovanovic;Thomas M. Eisenhaure;Thomas M. Eisenhaure;Rebecca H. Herbst;Rebecca H. Herbst

  • T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

    Moshe Biton;Moshe Biton;Adam L. Haber;Noga Rogel;Grace Burgin

  • A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation

    Itay Tirosh;Sharon Reikhav;Avraham A. Levy;Naama Barkai

  • Two strategies for gene regulation by promoter nucleosomes

    Itay Tirosh;Naama Barkai

  • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

    Mario L. Suvà;Esther Rheinbay;Shawn M. Gillespie;Anoop P. Patel

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    I. Tirosh;B. Izar;D. Treacy;J. J. Trombetta

  • Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade

    Parin Shah;Michael Cuoco;Mei-Ju Su;Johannes Melms

Frequent Co-Authors

Aviv Regev
Aviv Regev Genentech
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
Naama Barkai
Naama Barkai Weizmann Institute of Science
Keith L. Ligon
Keith L. Ligon Harvard University
Gad Getz
Gad Getz Broad Institute
Kai W. Wucherpfennig
Kai W. Wucherpfennig Harvard University
David N. Louis
David N. Louis Harvard University
Levi A. Garraway
Levi A. Garraway Roche (United States)

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