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Kai W. Wucherpfennig

Kai W. Wucherpfennig

D-Index & Metrics

Immunology

D-Index
113
Citations
51269
World Ranking
428
National Ranking
262

Medicine

D-Index
113
Citations
51269
World Ranking
4919
National Ranking
2665

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kai W. Wucherpfennig is affiliated with Harvard University in the United States. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these areas, their subfields of study include Oncology, Immunology, Molecular Biology, Genetics, and Hematology.

The scientist's work addresses several key topics including CAR-T cell therapy research, immune cell function and interaction, cancer immunotherapy and biomarkers, immunotherapy and immune responses, immune cells in cancer, T-cell and B-cell immunology, and the application of single-cell and spatial transcriptomics technologies.

Frequent venues for their publications feature a significant concentration in journals such as Blood, Cell, Cancer Research, Regular and Young Investigator Award Abstracts, and Cancer Cell. These venues reflect the focus on hematology, oncology, and immunology research.

Recent papers represent major contributions with a focus on cancer immunology and cellular interactions, including:

  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma (2021, Cancer Cell)
  • Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma (2021, Nature Medicine)
  • Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy (2020, Cell)
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021, Cell)
  • Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient (2020, Cell Stem Cell)

Their frequent co-authors include:

  • Jason W. Pyrdol
  • Nathan D. Mathewson
  • Adrienne Luoma
  • Mario L. Suvà
  • Aviv Regev

Kai W. Wucherpfennig's scholarly activity includes a wide array of publications in high-impact journals and repeated collaboration with established researchers in their field. Their work intersects immunological mechanisms and cancer biology, with a focus on how immune responses can be modulated to influence cancer progression and treatment outcomes.

They received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

    Peng Jiang;Shengqing Gu;Deng Pan;Jingxin Fu

  • An immunogenic personal neoantigen vaccine for patients with melanoma

    Patrick A. Ott;Zhuting Hu;Derin B. Keskin;Derin B. Keskin;Sachet A. Shukla;Sachet A. Shukla

  • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

    Kai W Wucherpfennig;Jack L Strominger

  • A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

    Livnat Jerby-Arnon;Parin Shah;Michael S. Cuoco;Christopher Rodman

  • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Derin B. Keskin;Annabelle J. Anandappa;Jing Sun;Itay Tirosh

  • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

    Thomas Korn;Jayagopala Reddy;Wenda Gao;Estelle Bettelli

  • Radiotherapy induces responses of lung cancer to CTLA-4 blockade

    Silvia C. Formenti;Nils Petter Rudqvist;Encouse Golden;Encouse Golden;Benjamin Cooper

  • A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

    Deng Pan;Aya Kobayashi;Aya Kobayashi;Peng Jiang;Lucas Ferrari de Andrade

  • MHC-II neoantigens shape tumour immunity and response to immunotherapy

    Elise Alspach;Danielle M. Lussier;Alexander P. Miceli;Ilya Kizhvatov

  • A functional and structural basis for TCR cross-reactivity in multiple sclerosis

    Heather L.E. Lang;Helle Jacobsen;Helle Jacobsen;Shinji Ikemizu;Christina Andersson;Christina Andersson

  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

    Mariella G. Filbin;Itay Tirosh;Itay Tirosh;Volker Hovestadt;Volker Hovestadt;McKenzie L. Shaw;McKenzie L. Shaw

  • Deconstructing the Peptide-MHC Specificity of T Cell Recognition

    Michael E. Birnbaum;Juan L. Mendoza;Dhruv K. Sethi;Shen Dong

  • The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex

    Matthew E. Call;Jason Pyrdol;Martin Wiedmann;Kai W. Wucherpfennig

  • Mechanisms for the induction of autoimmunity by infectious agents

    Kai W. Wucherpfennig

  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

    Toshiro Hara;Rony Chanoch-Myers;Nathan D. Mathewson;Nathan D. Mathewson;Chad Myskiw

  • Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

    Chenqi Xu;Etienne Gagnon;Matthew E. Call;Jason R. Schnell

  • Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

    Anneli Peters;Lisa A. Pitcher;Jenna M. Sullivan;Meike Mitsdoerffer

  • Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein

    Kai W. Wucherpfennig;Kohei Ota;Noriaki Endo;J. G. Seidman

  • Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

    Zhuting Hu;Donna E. Leet;Rosa L. Allesøe;Giacomo Oliveira

  • Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

    Kon Ho Lee;Kai W. Wucherpfennig;Don C. Wiley;Don C. Wiley

  • Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

    Kaushik Choudhuri;Jaime Llodrá;Eric W. Roth;Jones Tsai

  • Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

    Kathrine J. Smith;Jason Pyrdol;Laurent Gauthier;Don C. Wiley

Frequent Co-Authors

David A. Hafler
David A. Hafler Yale University
Jack L. Strominger
Jack L. Strominger Harvard University
Nir Hacohen
Nir Hacohen Harvard University
Aviv Regev
Aviv Regev Genentech
Itay Tirosh
Itay Tirosh Weizmann Institute of Science
Michael C. Carroll
Michael C. Carroll Boston Children's Hospital
Scott J. Rodig
Scott J. Rodig Harvard University
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
David A. Reardon
David A. Reardon Harvard University
Keith L. Ligon
Keith L. Ligon Harvard University

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