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Hartmut Wekerle

Hartmut Wekerle

D-Index & Metrics

Immunology

D-Index
112
Citations
43359
World Ranking
453
National Ranking
22

Medicine

D-Index
113
Citations
43521
World Ranking
4990
National Ranking
275

Overview

Hartmut Wekerle is affiliated with the Max Planck Society in Germany and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work primarily focuses on the fields of immunology, molecular biology, pathology and forensic medicine, epidemiology, and oncology.

The scientist's research centers on multiple sclerosis and related immune system mechanisms, with significant attention to gut microbiota and its impact on health. Main topics of study include:

  • Multiple Sclerosis Research Studies
  • Gut microbiota and health
  • Mycobacterium research and diagnosis
  • Immune Cell Function and Interaction
  • Polyomavirus and related diseases
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses

Wekerle's recent papers reflect these interests, with notable publications such as:

  • "Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course," 2022, published in Cell
  • "Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis," 2022, published in The Journal of Experimental Medicine
  • "Epstein-Barr virus sparks brain autoimmunity in multiple sclerosis," 2022, published in Nature
  • "A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity," 2023, published in Proceedings of the National Academy of Sciences
  • "Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging," 2023, published in Proceedings of the National Academy of Sciences

Throughout their career, Wekerle has frequently published in the following venues:

  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine
  • Nature
  • Cell
  • Neurotherapeutics

Their collaborative work has involved several frequent co-authors, including:

  • Lisa Ann Gerdes
  • Reinhard Hohlfeld
  • Hongsup Yoon
  • Andrea Flierl-Hecht
  • Roland Liblau

These collaborations and publication patterns emphasize Wekerle's engagement with multidisciplinary teams investigating immunological processes and autoimmune diseases. Their expertise spans cellular immune functions, interactions between T cells and B cells, and the role of infections such as Epstein-Barr virus in neurological autoimmunity.

Best Publications

  • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

    Kerstin Berer;Marsilius Mues;Michail Koutrolos;Zakeya Al Rasbi

  • The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

    Avraham Ben-Nun;Hartmut Wekerle;Irun R. Cohen

  • Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

    Martin Kerschensteiner;Eike Gallmeier;Lüder Behrens;Vivian Vargas Leal

  • Cellular immune reactivity within the CNS

    H. Wekerle;C. Linington;H. Lassmann;R. Meyermann

  • Astrocytes present myelin basic protein to encephalitogenic T-cell lines.

    Adriano Fontana;Walter Fierz;Hartmut Wekerle

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice.

    Kerstin Berer;Lisa Ann Gerdes;Egle Cekanaviciute;Xiaoming Jia

  • Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

    Avraham Ben-Nun;Hartmut Wekerle;Irun R. Cohen

  • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

    Ingo Bartholomäus;Naoto Kawakami;Francesca Odoardi;Christian Schläger

  • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma

    Markus Krumbholz;Diethilde Theil;Tobias Derfuss;Andreas Rosenwald

  • MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

    Andreas Junker;Markus Krumbholz;Sylvia Eisele;Hema Mohan

  • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice.

    Deming Sun;John N. Whitaker;Zhigang Huang;Di Liu

  • Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

    W Fierz;B Endler;K Reske;H Wekerle

  • Constitutive NF-kappa B activity in neurons.

    Christian Kaltschmidt;Barbara Kaltschmidt;H. Neumann;H. Wekerle

  • Induction of MHC class I genes in neurons

    Harald Neumann;Adolfo Cavalié;Dieter E. Jenne;Hartmut Wekerle

  • Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

    Alexander Flügel;Tomasz Berkowicz;Thomas Ritter;Marta Labeur

  • Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood

    Christian Skulina;Stephan Schmidt;Klaus Dornmair;Holger Babbe

  • T cells become licensed in the lung to enter the central nervous system

    Francesca Odoardi;Christopher Sie;Kristina Streyl;Vijay K. Ulaganathan

  • Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

    Deming Sun;Yufen Qin;Johanna Chluba;Jörg T. Epplen

  • Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization.

    Hartmut Wekerle;Uwe-Peter Ketelsen;Martin Ernst

  • The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis.

    Reinhard Hohlfeld;Martin Kerschensteiner;Christine Stadelmann;Hans Lassmann

  • Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals.

    M. Pette;K. Fujita;B. Kitze;J. N. Whitaker

Frequent Co-Authors

Hans Lassmann
Hans Lassmann Medical University of Vienna
Reinhard Hohlfeld
Reinhard Hohlfeld Ludwig-Maximilians-Universität München
Edgar Meinl
Edgar Meinl Ludwig-Maximilians-Universität München
Christopher Linington
Christopher Linington University of Glasgow
Klaus Dornmair
Klaus Dornmair Ludwig-Maximilians-Universität München
Harald Neumann
Harald Neumann University of Bonn
Jan Bauer
Jan Bauer Medical University of Vienna
Georg W. Kreutzberg
Georg W. Kreutzberg Max Planck Society
Dieter E. Jenne
Dieter E. Jenne Max Planck Society
Jörg T. Epplen
Jörg T. Epplen Ruhr University Bochum

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