World's Best Scientists 2026 revealed!

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Immunology

D-Index
113
Citations
43277
World Ranking
436
National Ranking
19

Medicine

D-Index
114
Citations
44085
World Ranking
4778
National Ranking
263

Research.com Recognitions

  • 2005 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Neurosciences

Overview

Reinhard Hohlfeld is affiliated with Ludwig-Maximilians-Universität München in Germany and specializes primarily in Medicine, focusing on multiple research fields related to pathology, immunology, and neurology. The scientist's work covers a range of subfields including Pathology and Forensic Medicine, Molecular Biology, Immunology, Neurology, and Oncology.

The main topics of their research reflect an emphasis on immunological mechanisms and neurological diseases, particularly multiple sclerosis. These topics include:

  • Multiple Sclerosis Research Studies
  • T-cell and B-cell Immunology
  • Gut microbiota and health
  • Peripheral Neuropathies and Disorders
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mycobacterium research and diagnosis
  • Immunotherapy and Immune Responses

Reinhard Hohlfeld has coauthored frequently with several researchers, notably:

  • Lisa Ann Gerdes
  • Tania Kümpfel
  • Eduardo Beltrán
  • Xavier Montalbán
  • Andrea Flierl-Hecht

The scientist's publication record includes appearances in prominent venues such as:

  • Neurology
  • Proceedings of the National Academy of Sciences
  • Brain
  • Multiple Sclerosis Journal
  • Annals of Neurology

Selected research publications by Reinhard Hohlfeld include:

  • "Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course," 2022, Cell
  • "Role of B Cells in Multiple Sclerosis and Related Disorders," 2020, Annals of Neurology
  • "Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study," 2021, JAMA Neurology
  • "The role of the gut microbiota in multiple sclerosis," 2022, Nature Reviews Neurology
  • "Twin study reveals non-heritable immune perturbations in multiple sclerosis," 2022, Nature

In 2005, Reinhard Hohlfeld received recognition from the German National Academy of Sciences Leopoldina for contributions to Neurosciences.

Best Publications

  • A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

    Ludwig Kappos;Ernst Wilhelm Radue;Paul O'Connor;Chris Polman

  • Polymyositis and Dermatomyositis

    Marinos C Dalakas;Reinhard Hohlfeld

  • Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

    Holger Babbe;Axel Roers;Ari Waisman;Hans Lassmann

  • Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

    Martin Kerschensteiner;Eike Gallmeier;Lüder Behrens;Vivian Vargas Leal

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice.

    Kerstin Berer;Lisa Ann Gerdes;Egle Cekanaviciute;Xiaoming Jia

  • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma

    Markus Krumbholz;Diethilde Theil;Tobias Derfuss;Andreas Rosenwald

  • MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

    Andreas Junker;Markus Krumbholz;Sylvia Eisele;Hema Mohan

  • Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment.

    Markus Krumbholz;Diethilde Theil;Sabine Cepok;Bernhard Hemmer

  • BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?

    Christine Stadelmann;Martin Kerschensteiner;Thomas Misgeld;Wolfgang Brück

  • Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood

    Christian Skulina;Stephan Schmidt;Klaus Dornmair;Holger Babbe

  • Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives.

    R Hohlfeld

  • Neurofascin as a novel target for autoantibody-mediated axonal injury

    Emily K. Mathey;Tobias Derfuss;Maria K. Storch;Kieran R. Williams

  • The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis.

    Reinhard Hohlfeld;Martin Kerschensteiner;Christine Stadelmann;Hans Lassmann

  • Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

    Ludwig Kappos;David Bates;Gilles Edan;Mefkûre Eraksoy

  • B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation.

    Edgar Meinl;Markus Krumbholz;Reinhard Hohlfeld

  • Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica

    Sven Jarius;Friedemann Paul;Diego Franciotta;Patrick Waters

  • Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

    Unknown

  • Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells.

    Oliver Neuhaus;Cinthia Farina;Alexander Yassouridis;Heinz Wiendl

  • Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab

    H. L. Pellkofer;M. Krumbholz;A. Berthele;B. Hemmer

  • Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases

    Martin Kerschensteiner;Christine Stadelmann;Georg Dechant;Hartmut Wekerle

  • Glatiramer acetate‐specific T‐helper 1‐ and 2‐type cell lines produce BDNF: implications for multiple sclerosis therapy

    Tjalf Ziemssen;Tania Kümpfel;Wolfgang E. F. Klinkert;Oliver Neuhaus

Frequent Co-Authors

Edgar Meinl
Edgar Meinl Ludwig-Maximilians-Universität München
Hartmut Wekerle
Hartmut Wekerle Max Planck Society
Heinz Wiendl
Heinz Wiendl University of Münster
Klaus Dornmair
Klaus Dornmair Ludwig-Maximilians-Universität München
Ralf Gold
Ralf Gold Ruhr University Bochum
Frauke Zipp
Frauke Zipp Johannes Gutenberg University of Mainz
Frank Weber
Frank Weber HEMAP AG
Ludwig Kappos
Ludwig Kappos University Hospital of Basel
Klaus V. Toyka
Klaus V. Toyka University of Würzburg
Hans-Peter Hartung
Hans-Peter Hartung Heinrich Heine University Düsseldorf

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