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Biology and Biochemistry

D-Index
66
Citations
13280
World Ranking
8817
National Ranking
78

Overview

Neta Ilan is affiliated with the Technion - Israel Institute of Technology in Israel. Their research primarily focuses on the biochemical and molecular biology fields, with significant contributions to molecular biology, cell biology, cancer research, oncology, and surgery.

The scientist's main research topics include proteoglycans and glycosaminoglycans, fibroblast growth factor research, glycosylation and glycoproteins, Wnt/β-catenin signaling in development and cancer, peptidase inhibition and analysis, Hippo pathway signaling and YAP/TAZ, and protease and inhibitor mechanisms.

Neta Ilan has published extensively, with frequent publications appearing in several well-known venues. These include:

  • Cell Death and Disease
  • Matrix Biology
  • Frontiers in Oncology
  • Advances in Experimental Medicine and Biology
  • Proceedings of the National Academy of Sciences

Recent papers authored or co-authored by Neta Ilan cover a range of topics related to heparanase and tumor biology, including:

  • "Forty Years of Basic and Translational Heparanase Research," 2020, published in Advances in Experimental Medicine and Biology
  • "Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo," 2022, published in Proceedings of the National Academy of Sciences
  • "Biology of the Heparanase-Heparan Sulfate Axis and Its Role in Disease Pathogenesis," 2021, published in Seminars in Thrombosis and Hemostasis
  • "Significance of host heparanase in promoting tumor growth and metastasis," 2020, published in Matrix Biology
  • "Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression," 2021, published in Matrix Biology

The scientist has collaborated frequently with several researchers, including:

  • Israël Vlodavsky
  • Uri Barash
  • Miriam Gross-Cohen
  • Inna Naroditsky
  • Ralph D. Sanderson

Neta Ilan contributed to book publications as well, with work published by Springer Nature, including the book titled "Heparanase" in 2020.

Best Publications

  • Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.

    Neta Ilan;Michael Elkin;Israel Vlodavsky

  • Heparanase as mediator of angiogenesis: mode of action

    Michael Elkin;Neta Ilan;Rivka Ishai-Michaeli;Yael Friedmann

  • Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

    Neta Ilan;Sepi Mahooti;Joseph A. Madri

  • Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.

    Israel Vlodavsky;Neta Ilan;Annamaria Naggi;Benito Casu

  • PECAM-1: old friend, new partners

    Neta Ilan;Joseph A Madri

  • Heparanase Induces Vascular Endothelial Growth Factor Expression: Correlation with p38 Phosphorylation Levels and Src Activation

    Anna Zetser;Yulia Bashenko;Evgeny Edovitsky;Flonia Levy-Adam

  • Processing and activation of latent heparanase occurs in lysosomes

    Anna Zetser;Flonia Levy-Adam;Victoria Kaplan;Svetlana Gingis-Velitski

  • Heparanase Induces Endothelial Cell Migration via Protein Kinase B/Akt Activation

    Svetlana Gingis-Velitski;Anna Zetser;Moshe Y. Flugelman;Israel Vlodavsky

  • Significance of Heparanase in Cancer and Inflammation

    Israel Vlodavsky;Phillip Beckhove;Immanuel Lerner;Claudio Pisano

  • Heparanase: busy at the cell surface

    Liat Fux;Neta Ilan;Ralph D. Sanderson;Israel Vlodavsky

  • Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

    Ralph D. Sanderson;Michael Elkin;Alan C. Rapraeger;Neta Ilan

  • Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans.

    Svetlana Gingis-Velitski;Anna Zetser;Victoria Kaplan;Olga Ben-Zaken

  • Heparanase Affects Adhesive and Tumorigenic Potential of Human Glioma Cells

    Anna Zetser;Yulia Bashenko;Hua-Quan Miao;Israel Vlodavsky

  • Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models

    Eyal Zcharia;Rachel Zilka;Alon Yaar;Oron Yacoby-Zeevi

  • Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

    Uri Barash;Victoria Cohen-Kaplan;Ilana Dowek;Ralph D. Sanderson

  • Heparanase: From basic research to therapeutic applications in cancer and inflammation.

    Israel Vlodavsky;Preeti Singh;Ilanit Boyango;Lilach Gutter-Kapon

  • PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics

    Neta Ilan;Amir Mohsenin;Lawrence Cheung;Joseph A. Madri

  • PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin.

    Neta Ilan;Sepi Mahooti;David L. Rimm;Joseph A. Madri

  • Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.

    Flonia Levy-Adam;Sari Feld;Victoria Cohen-Kaplan;Anna Shteingauz

  • Heparanase induces tissue factor expression in vascular endothelial and cancer cells

    Y. Nadir;B. Brenner;A. Zetser;N. Ilan

Frequent Co-Authors

Israel Vlodavsky
Israel Vlodavsky Technion – Israel Institute of Technology
Ralph D. Sanderson
Ralph D. Sanderson University of Alabama at Birmingham
Jin-Ping Li
Jin-Ping Li Uppsala University
Joseph A. Madri
Joseph A. Madri Yale University
Arnon Nagler
Arnon Nagler Sheba Medical Center
Benito Casu
Benito Casu Istituto G. Ronzoni
Annamaria Naggi
Annamaria Naggi University of Brescia
Ronen Alon
Ronen Alon Weizmann Institute of Science
Eviatar Nevo
Eviatar Nevo University of Haifa
Daniela Novick
Daniela Novick Weizmann Institute of Science

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