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Biology and Biochemistry

D-Index
79
Citations
17859
World Ranking
4404
National Ranking
2140

Overview

Ralph D. Sanderson is affiliated with the University of Alabama at Birmingham in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these domains, Sanderson's work has a particular focus on subfields such as Cell Biology, Molecular Biology, Cancer Research, Oncology, and Hematology.

The scientist's body of work extensively covers several main topics. These include proteoglycans and glycosaminoglycans research, glycosylation and glycoproteins research, protease and inhibitor mechanisms, multiple myeloma research and treatments, trauma, hemostasis, coagulopathy, resuscitation, fibroblast growth factor research, and extracellular vesicles in disease.

Sanderson has contributed to several research publications, with notable papers including:

  • Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression, 2020, Journal of Histochemistry & Cytochemistry
  • Forty Years of Basic and Translational Heparanase Research, 2020, Advances in Experimental Medicine and Biology
  • Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress-related AMPK/FoxO1 signaling, 2022, JCI Insight
  • Significance of host heparanase in promoting tumor growth and metastasis, 2020, Matrix Biology
  • Heparanase: A Dynamic Promoter of Myeloma Progression, 2020, Advances in Experimental Medicine and Biology

They have coauthored frequently with several researchers, including Kaushlendra Tripathi, Israël Vlodavsky, Shyam Bandari, Neta Ilan, and Jillian R. Richter.

Sanderson's publications often appear in specific scientific venues, such as Advances in Experimental Medicine and Biology, Matrix Biology, Proteoglycan Research, Cells, and UNC Libraries. These consistent publication venues reflect specialization in their research topics.

In addition to journal articles, Sanderson has published a book titled Heparanase with Springer Nature in 2020. The book has attracted scholarly citations and adds to their contribution to the field.

Best Publications

  • Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

    Fenghuang Zhan;Johanna S. Hardin;Bob Kordsmeier;Klaus Bumm

  • Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

    Renato V. Iozzo;Ralph D. Sanderson

  • B lymphocytes express and lose syndecan at specific stages of differentiation.

    R D Sanderson;P Lalor;M Bernfield

  • Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes

    Camilla A. Thompson;Anurag Purushothaman;Vishnu C. Ramani;Israel Vlodavsky

  • The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

    K Iba;R Albrechtsen;B Gilpin;Camilla Frohlich

  • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

    Therese Standal;Carina Seidel;Øyvind Hjertner;Torben Plesner

  • Heparanase Enhances Syndecan-1 Shedding A NOVEL MECHANISM FOR STIMULATION OF TUMOR GROWTH AND METASTASIS

    Yang Yang;Veronica Macleod;Hua-Quan Miao;Allison Theus

  • Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors.

    M Bernfield;R D Sanderson

  • Heparan sulfate proteoglycans in invasion and metastasis

    Ralph D. Sanderson

  • Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

    Anurag Purushothaman;Shyam Kumar Bandari;Jian Liu;James A. Mobley

  • SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/ syndecan-1 axis

    Joseph P. Ritchie;Vishnu C. Ramani;Yongsheng Ren;Annamaria Naggi

  • Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

    Nikos K. Karamanos;Nikos K. Karamanos;Zoi Piperigkou;Zoi Piperigkou;Achilleas D. Theocharis;Hideto Watanabe

  • Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

    Anurag Purushothaman;Toru Uyama;Fumi Kobayashi;Shuhei Yamada

  • Syndecan-1 Is a Multifunctional Regulator of Myeloma Pathobiology: Control of Tumor Cell Survival, Growth, and Bone Cell Differentiation

    Madhav V. Dhodapkar;Etsuko Abe;Allison Theus;Marie Lacy

  • Heparanase: busy at the cell surface

    Liat Fux;Neta Ilan;Ralph D. Sanderson;Israel Vlodavsky

  • Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen

    Ronnie C. Ridley;Huiquing Xiao;Hiroyuki Hata;Jeff Woodliff

  • Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.

    Ralph D. Sanderson;Yang Yang;Larry J. Suva;Thomas Kelly

  • Soluble syndecan-1 promotes growth of myeloma tumors in vivo.

    Yang Yang;Shmuel Yaccoby;Wei Liu;J. Kevin Langford

  • Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

    Ralph D. Sanderson;Michael Elkin;Alan C. Rapraeger;Neta Ilan

  • Heparan Sulfate Proteoglycans as Adhesive and Anti-invasive Molecules SYNDECANS AND GLYPICAN HAVE DISTINCT FUNCTIONS

    Wei Liu;E. David Litwack;Michelle J. Stanley;J. Kevin Langford

Frequent Co-Authors

Israel Vlodavsky
Israel Vlodavsky Technion – Israel Institute of Technology
Neta Ilan
Neta Ilan Technion – Israel Institute of Technology
Richard Mayne
Richard Mayne University of Alabama at Birmingham
Joshua Epstein
Joshua Epstein University of Arkansas for Medical Sciences
John D. Shaughnessy
John D. Shaughnessy University of Arkansas for Medical Sciences
Thomas F. Linsenmayer
Thomas F. Linsenmayer Harvard Medical School
Alan C. Rapraeger
Alan C. Rapraeger University of Wisconsin–Madison
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Benito Casu
Benito Casu Istituto G. Ronzoni
Bart Barlogie
Bart Barlogie Mount Sinai Hospital

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