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Biology and Biochemistry

D-Index
62
Citations
14832
World Ranking
10726
National Ranking
4656

Overview

Alan C. Rapraeger is affiliated with the University of Wisconsin-Madison in the United States and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. They have produced work that spans several subfields, including Molecular Biology, Immunology and Allergy, Hematology, Cell Biology, and Oncology.

Their research addresses multiple specialized topics such as Cell Adhesion Molecules Research, Multiple Myeloma Research and Treatments, Protein Degradation and Inhibitors, Proteoglycans and glycosaminoglycans research, HER2/EGFR in Cancer Research, Chronic Lymphocytic Leukemia Research, and Fibroblast Growth Factor Research.

Alan C. Rapraeger's recent papers include the following:

  • Syndecans and Their Synstatins: Targeting an Organizer of Receptor Tyrosine Kinase Signaling at the Cell-Matrix Interface (2021, Frontiers in Oncology)
  • Ponatinib sensitizes myeloma cells to MEK inhibition in the high-risk VQ model (2022, Scientific Reports)
  • Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTNIGF1R (2023, Cancer Research Communications)
  • Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression (2022, Journal of Biological Chemistry)
  • Exosomes are specialized vehicles to induce fibronectin assembly (2025, bioRxiv [Cold Spring Harbor Laboratory])

Frequent co-authors collaborating with Alan C. Rapraeger include:

  • Oisun Jung
  • Evan Flietner
  • Zhi Wen
  • Adhithi Rajagopalan
  • Joshua Wiesner

Their publications have appeared in a range of scientific venues, reflecting diverse research interests:

  • Frontiers in Oncology
  • Scientific Reports
  • Cancer Research Communications
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.

    Alan C. Rapraeger;Alison Krufka;Bradley B. Olwin

  • Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

    S Guimond;M Maccarana;B.B. Olwin;U Lindahl

  • Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration.

    D.D.W. Cornelison;Mark S. Filla;Heather M. Stanley;Alan C. Rapraeger

  • Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells.

    A Rapraeger;M Jalkanen;M Bernfield

  • The cell surface proteoglycan from mouse mammary epithelial cells bears chondroitin sulfate and heparan sulfate glycosaminoglycans.

    A Rapraeger;M Jalkanen;E Endo;J Koda

  • Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens.

    J E Koda;A Rapraeger;M Bernfield

  • Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.

    Bradley B. Olwin;Alan Rapraeger

  • Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.

    D.D.W. Cornelison;Sarah A. Wilcox-Adelman;Paul F. Goetinck;Heikki Rauvala

  • Syndecans in tumor cell adhesion and signaling

    DeannaLee M Beauvais;Alan C Rapraeger

  • The syndecan-1 ectodomain regulates αvβ3 integrin activity in human mammary carcinoma cells

    DeannaLee M. Beauvais;Brandon J. Burbach;Alan C. Rapraeger

  • Heparan sulfate proteoglycans from mouse mammary epithelial cells: localization on the cell surface with a monoclonal antibody.

    M Jalkanen;H Nguyen;A Rapraeger;N Kurn

  • Heparan sulfate-mediated binding of epithelial cell surface proteoglycan to thrombospondin.

    Xi Sun;D. F. Mosher;A. Rapraeger

  • Syndecan-1 regulates αvβ3 and αvβ5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

    DeannaLee M. Beauvais;Brian J. Ell;Andrea R. McWhorter;Alan C. Rapraeger

  • Syndecan-Regulated Receptor Signaling

    Alan C. Rapraeger

  • Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis.

    Anurag Purushothaman;Toru Uyama;Fumi Kobayashi;Shuhei Yamada

  • Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from its membrane-associated domain.

    M Jalkanen;A Rapraeger;S Saunders;M Bernfield

  • Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly

    Benjamin L. Allen;Alan C. Rapraeger

  • Heparan sulfate proteoglycans from mouse mammary epithelial cells. A putative membrane proteoglycan associates quantitatively with lipid vesicles.

    A C Rapraeger;M Bernfield

  • Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

    Ralph D. Sanderson;Michael Elkin;Alan C. Rapraeger;Neta Ilan

  • Cell surface proteoglycan of mammary epithelial cells. Protease releases a heparan sulfate-rich ectodomain from a putative membrane-anchored domain.

    A Rapraeger;M Bernfield

Frequent Co-Authors

Richard A. Anderson
Richard A. Anderson University of Edinburgh
Paul F. Lambert
Paul F. Lambert University of Wisconsin–Madison
Bradley B. Olwin
Bradley B. Olwin University of Colorado Boulder
Ralph D. Sanderson
Ralph D. Sanderson University of Alabama at Birmingham
Markku Jalkanen
Markku Jalkanen Faron Pharmaceuticals
James Varani
James Varani University of Michigan–Ann Arbor
E. Helene Sage
E. Helene Sage Benaroya Research Institute
Kazuyuki Sugahara
Kazuyuki Sugahara Hokkaido University
Paul F. Goetinck
Paul F. Goetinck Harvard University

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