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Guido David

Guido David

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
18817
World Ranking
6293
National Ranking
107

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Guido David is affiliated with KU Leuven in Belgium and specializes primarily in Biochemistry, Genetics, and Molecular Biology, with additional research contributions in Medicine. Their work spans multiple subfields including Molecular Biology, Immunology and Allergy, Cancer Research, Cell Biology, and Pulmonary and Respiratory Medicine.

Their research focuses extensively on extracellular vesicles and related biological mechanisms. Major topics of study include extracellular vesicles in disease, cell adhesion molecules, microRNA in disease regulation, proteoglycans and glycosaminoglycans research, protease and inhibitor mechanisms, RNA interference and gene delivery, as well as blood properties and coagulation.

Guido David has authored several papers published in recognized scientific venues. Notable publications include:

  • Tetraspanin-6 negatively regulates exosome production, 2020, Proceedings of the National Academy of Sciences
  • Syntenin-knock out reduces exosome turnover and viral transduction, 2021, Scientific Reports
  • A Journey on Extracellular Vesicles for Matrix Metalloproteinases: A Mechanistic Perspective, 2022, Frontiers in Cell and Developmental Biology
  • Heparanase Involvement in Exosome Formation, 2020, Advances in Experimental Medicine and Biology
  • PDZ scaffolds regulate extracellular vesicle production, composition, and uptake, 2023, Proceedings of the National Academy of Sciences

The scholar collaborates frequently with other researchers, including Pascale Zimmermann, Rania Ghossoub, Raphaël Leblanc, Stéphane Audebert, and Antonio Luis Egea-Jiménez.

Their work is commonly published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Frontiers in Cell and Developmental Biology, Scientific Reports, and Advances in Experimental Medicine and Biology.

Best Publications

  • Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

    Maria Francesca Baietti;Zhe Zhang;Zhe Zhang;Eva Mortier;Aurélie Melchior

  • Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

    David Aviezer;Dalit Hecht;Michal Safran;Magdalena Eisinger

  • Developmental changes in heparan sulfate expression: in situ detection with mAbs.

    G. David;Xiao Mei Bai;B. Van Der Schueren;J.-J. Cassiman

  • Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

    Jan-Johannes Grootjans;Pascale Zimmermann;Gunter Reekmans;Anne Smets

  • Integral membrane heparan sulfate proteoglycans.

    Guido David

  • Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.

    G David;V Lories;B Decock;P Marynen

  • Heparanase activates the syndecan-syntenin-ALIX exosome pathway

    Bart Roucourt;Sofie Meeussen;Jie Bao;Pascale Zimmermann

  • Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages

    Andrew C. S. Saphire;Michael D. Bobardt;Zhe Zhang;Guido David

  • Cell surface heparan sulfate proteoglycans from human vascular endothelial cells. Core protein characterization and antithrombin III binding properties.

    G Mertens;J J Cassiman;H Van den Berghe;J Vermylen

  • Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican.

    R Steinfeld;H Van Den Berghe;G David

  • The syndecans, tuners of transmembrane signaling

    Pascale Zimmermann;Guido David

  • Mammalian heparanase: what is the message?

    Veronique Vreys;Veronique Vreys;Guido David;Guido David

  • Syndecan Captures, Protects, and Transmits HIV to T Lymphocytes

    Michael D Bobardt;Andrew C.S Saphire;Hsiu-Cheng Hung;Xiaocong Yu

  • Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

    R. Van Der Voort;T. E. I. Taher;V. J. M. Wielenga;M. Spaargaren

  • Glypican-1 Is a VEGF165 Binding Proteoglycan That Acts as an Extracellular Chaperone for VEGF165

    Stela Gengrinovitch;Bluma Berman;Guido David;Larry Witte

  • PIP2-PDZ Domain Binding Controls the Association of Syntenin with the Plasma Membrane

    Pascale Zimmermann;Kris Meerschaert;Gunter Reekmans;Iris Leenaerts

  • Syndecan Recyling Is Controlled by Syntenin-PIP2 Interaction and Arf6

    Pascale Zimmermann;Zhe Zhang;Gisèle Degeest;Eva Mortier

  • Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts.

    P. Marynen;Jianjun Zhang;J. J. Cassiman;H. Van den Berghe

  • VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis

    Lukas J.A.C. Hawinkels;Kim Zuidwijk;Hein W. Verspaget;Eveline S.M. de Jonge-Muller

  • Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments.

    Pascale Zimmermann;Daniela Tomatis;Marcela Rosas;Johan Grootjans

Frequent Co-Authors

Peter Marynen
Peter Marynen KU Leuven
Marcel M. Verbeek
Marcel M. Verbeek Radboud University
Philippe Gallay
Philippe Gallay Scripps Research Institute
Pieter Wesseling
Pieter Wesseling University of Amsterdam
Jack van Horssen
Jack van Horssen Vrije Universiteit Amsterdam
Lambert P. van den Heuvel
Lambert P. van den Heuvel Radboud University

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