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Biology and Biochemistry

D-Index
52
Citations
9290
World Ranking
16726
National Ranking
470

Overview

John M. Whitelock is affiliated with the University of New South Wales in Australia. Their research is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Materials Science. The scientist's work extensively covers subfields such as Cell Biology, Biomaterials, Molecular Biology, Biomedical Engineering, and Materials Chemistry.

The main research topics explored include:

  • Proteoglycans and glycosaminoglycans research
  • Silk-based biomaterials and applications
  • Protease and Inhibitor Mechanisms
  • Electrospun Nanofibers in Biomedical Applications
  • Advanced Nanomaterials in Catalysis
  • Glycosylation and Glycoproteins Research
  • Micro and Nano Robotics

Representative recent papers authored or co-authored by John M. Whitelock include:

  • "Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan," 2020, Frontiers in Oncology
  • "The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology," 2020, Journal of Histochemistry & Cytochemistry
  • "A Biomolecular Toolbox for Precision Nanomotors," 2022, Advanced Materials
  • "A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials," 2020, Advanced Science
  • "Microchannels Are an Architectural Cue That Promotes Integration and Vascularization of Silk Biomaterials in Vivo," 2020, ACS Biomaterials Science & Engineering

Frequent co-authors collaborating with John M. Whitelock are:

  • Megan S. Lord
  • Jelena Rnjak-Kovacina
  • Kang Liang
  • Joel Yong
  • Ha Na Kim

Key venues where their work has been published include:

  • Advanced Healthcare Materials
  • ACS Biomaterials Science & Engineering
  • Frontiers in Oncology
  • Journal of Histochemistry & Cytochemistry
  • Advanced Materials

Best Publications

  • The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

    John M. Whitelock;Alan D. Murdoch;Renato V. Iozzo;P. Anne Underwood

  • Heparan sulfate: a complex polymer charged with biological activity.

    John M. Whitelock;Renato V. Iozzo

  • Diverse cell signaling events modulated by perlecan.

    John M. Whitelock;James Melrose;Renato V. Iozzo

  • Oxidative damage to extracellular matrix and its role in human pathologies.

    Martin D. Rees;Eleanor C. Kennett;John M. Whitelock;Michael J. Davies;Michael J. Davies

  • Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo.

    B Sharma;M Handler;I Eichstetter;J M Whitelock

  • CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

    Claire Vennin;Claire Vennin;Claire Vennin;Pauline Mélénec;Pauline Mélénec;Romain Rouet;Romain Rouet;Max Nobis;Max Nobis

  • Not All Perlecans Are Created Equal INTERACTIONS WITH FIBROBLAST GROWTH FACTOR (FGF) 2 AND FGF RECEPTORS

    Sarah Knox;Sarah Knox;Catherine L R Merry;Sally E Stringer;James Melrose

  • Perlecan: how does one molecule do so many things?

    S. M. Knox;J. M. Whitelock

  • Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis

    Vaishali N. Patel;Sarah M. Knox;Karen M. Likar;Karen M. Likar;Colin A. Lathrop

  • The Protein Core of the Proteoglycan Perlecan Binds Specifically to Fibroblast Growth Factor-7

    Maurizio Mongiat;Kathryn Taylor;Juliet Otto;Sirpa Aho

  • Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.

    J G Lyons;B Birkedal-Hansen;M C Pierson;J M Whitelock

  • Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study.

    James Melrose;Susan Smith;Martin Cake;Richard Read

  • Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells

    John M. Whitelock;Lloyd D. Graham;James Melrose;Alan D. Murdoch

  • The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins.

    Megan S. Lord;Bill Cheng;Simon J. McCarthy;Moon Sun Jung

  • Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.

    Jason J. Zoeller;John M. Whitelock;Renato V. Iozzo

  • The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response.

    M.S. Lord;B.G. Cousins;P.J. Doherty;J.M. Whitelock

  • Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan.

    Zehra Elgundi;Michael Papanicolaou;Gretel Major;Thomas R. Cox;Thomas R. Cox

  • Structural and functional characterisation of poly(vinyl alcohol) and heparin hydrogels

    Anastasia Nilasaroya;Laura A. Poole-Warren;John M. Whitelock;Penny Jo Martens

  • A central function for perlecan in skeletal muscle and cardiovascular development.

    Jason J. Zoeller;Angela McQuillan;John Whitelock;Shiu-Ying Ho

  • The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.

    Megan S. Lord;Christine Y. Chuang;James Melrose;Michael J. Davies

Frequent Co-Authors

Michael J. Davies
Michael J. Davies University of Copenhagen
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Ernst Malle
Ernst Malle Medical University of Graz
Niclas G. Karlsson
Niclas G. Karlsson University of Gothenburg
Laura A. Poole-Warren
Laura A. Poole-Warren University of New South Wales
Erik W. Thompson
Erik W. Thompson Queensland University of Technology
Christopher B. Little
Christopher B. Little University of Sydney
Nicolle H. Packer
Nicolle H. Packer Macquarie University
Rose Amal
Rose Amal University of New South Wales
Wey Yang Teoh
Wey Yang Teoh University of New South Wales

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