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Christopher B. Little

Christopher B. Little

University of Sydney
Australia

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
16859
World Ranking
7031
National Ranking
175

Medicine

D-Index
71
Citations
17251
World Ranking
20002
National Ranking
684

Christopher B. Little publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Christopher B. Little sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 289 publications — 76th percentile

76% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Christopher B. Little D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Christopher B. Little sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 70 D-Index — 65th percentile

65% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Christopher B. Little is affiliated with the University of Sydney in Australia and focuses on research primarily within the field of Medicine. Their work encompasses several specialized subfields including Rheumatology, Surgery, Pharmacology, Molecular Biology, and Orthopedics and Sports Medicine.

The scientific contributions of Christopher B. Little largely revolve around key topics such as:

  • Osteoarthritis Treatment and Mechanisms
  • Inflammatory mediators and NSAID effects
  • Knee injuries and reconstruction techniques
  • Tendon Structure and Treatment
  • Total Knee Arthroplasty Outcomes
  • Cytokine Signaling Pathways and Interactions
  • Rheumatoid Arthritis Research and Therapies

Among recent publications, notable works include:

  • The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date, 2021, Drug Design Development and Therapy
  • Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis, 2020, Annals of the Rheumatic Diseases
  • OA foundations - experimental models of osteoarthritis, 2021, Osteoarthritis and Cartilage
  • Monocytes, Macrophages, and Their Potential Niches in Synovial Joints - Therapeutic Targets in Post-Traumatic Osteoarthritis?, 2021, Frontiers in Immunology
  • Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies, 2023, Bioactive Materials

Christopher B. Little has frequently collaborated with a core group of co-authors including Carina L. Blaker, Sanaa Zaki, Cindy C. Shu, Elizabeth Clarke, and Patrick Haubruck. These collaborations have contributed significantly to their overall research output.

Their work has appeared predominantly in key scientific venues such as:

  • Osteoarthritis and Cartilage
  • Annals of the Rheumatic Diseases
  • The American Journal of Sports Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Osteoarthritis and Cartilage Open

Best Publications

  • The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

    N. Gerwin;A. M. Bendele;S. Glasson;Cathy S Carlson

  • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

    Heather Stanton;Fraser M. Rogerson;Charlotte J. East;Suzanne B. Golub

  • Are animal models useful for studying human disc disorders/degeneration?

    Mauro Alini;Stephen Eisenstein;Keita Ito;Christopher Little

  • MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT

    C. B. Little;A. Barai;D. Burkhardt;S. M. Smith

  • Mechanisms involved in cartilage proteoglycan catabolism.

    Bruce Caterson;Carl R. Flannery;Clare Elizabeth Hughes;Chris B. Little

  • n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation *

    Clare L. Curtis;Clare Elizabeth Hughes;C. R. Flannery;Chris B. Little

  • Post-traumatic osteoarthritis: from mouse models to clinical trials

    Christopher B. Little;David J. Hunter

  • Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

    Chris B. Little;Carl R. Flannery;Clare E. Hughes;John S. Mort

  • Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

    Clare L. Curtis;Sarah G. Rees;Chris B. Little;Carl R. Flannery

  • Proteoglycan degradation by the ADAMTS family of proteinases.

    Heather Stanton;James Melrose;Christopher B. Little;Amanda J. Fosang

  • Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

    Christopher B. Little;Clare T. Meeker;Suzanne B. Golub;Kate E. Lawlor

  • Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

    B.Y. Chan;E.S. Fuller;A.K. Russell;S.M. Smith

  • Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis

    Allan A Young;Susan V. McLennan;Margaret M. Smith;Susan M Smith

  • Histopathology atlas of animal model systems – overview of guiding principles

    T. Aigner;J.L. Cook;N. Gerwin;S.S. Glasson

  • What constitutes an "animal model of osteoarthritis"--the need for consensus?

    C.B. Little;S. Zaki;S. Zaki

  • Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.

    Christopher B. Little;Clare Elizabeth Hughes;Clare L. Curtis;Mike J. Janusz

  • Catabolism of aggrecan, decorin and biglycan in tendon.

    Sarah G. Rees;Carl R. Flannery;Chris B. Little;Clare Elizabeth Hughes

  • Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

    Carl R Flannery;Chris B Little;Bruce Caterson;Clare E Hughes

  • Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

    Shireen R Lamandé;Shireen R Lamandé;Yuan Yuan;Irma L Gresshoff;Irma L Gresshoff;Lynn Rowley

  • IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage.

    Carl R. Flannery;Chris B. Little;Clare Elizabeth Hughes;Clare L. Curtis

Frequent Co-Authors

Bruce Caterson
Bruce Caterson Cardiff University
Clare Elizabeth Hughes
Clare Elizabeth Hughes Cardiff University
Amanda J. Fosang
Amanda J. Fosang Royal Children's Hospital
John F. Bateman
John F. Bateman University of Melbourne
Peter Ghosh
Peter Ghosh Hudson Institute of Medical Research
Paul W. Hodges
Paul W. Hodges University of Queensland
David J. Hunter
David J. Hunter Harvard University
John L. Harwood
John L. Harwood Cardiff University
Richard Wilson
Richard Wilson Department for Environment Food and Rural Affairs
Hala Zreiqat
Hala Zreiqat University of Sydney

External Links

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Best Scientists Citing Christopher B. Little

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Publications: 58

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Publications: 55

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Publications: 54

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University of Liverpool

Publications: 51

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Ali Mobasheri

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Publications: 47

Amanda J. Fosang

Amanda J. Fosang

Royal Children's Hospital

Publications: 43

John D. Sandy

John D. Sandy

Rush University Medical Center

Publications: 41

Hideaki Nagase

Hideaki Nagase

University of Oxford

Publications: 40

Di Chen

Di Chen

Chinese Academy of Sciences

Publications: 37

Jean-Pierre Pelletier

Jean-Pierre Pelletier

University of Montreal

Publications: 36

Henning Madry

Henning Madry

Saarland University

Publications: 35

Johanne Martel-Pelletier

Johanne Martel-Pelletier

University of Montreal

Publications: 34

Morten A. Karsdal

Morten A. Karsdal

University of Southern Denmark

Publications: 33

Yves Henrotin

Yves Henrotin

University of Liège

Publications: 33

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Lei Wei

Wuhan University

Publications: 33

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Alan J. Grodzinsky

MIT

Publications: 33

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