Christopher B. Little

Overview

Best Publications

• The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

  N. Gerwin;A. M. Bendele;S. Glasson;Cathy S Carlson

  1665
  Citations

• ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

  Heather Stanton;Fraser M. Rogerson;Charlotte J. East;Suzanne B. Golub

  1004
  Citations

• Are animal models useful for studying human disc disorders/degeneration?

  Mauro Alini;Stephen Eisenstein;Keita Ito;Christopher Little

  848
  Citations

• MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT

  C. B. Little;A. Barai;D. Burkhardt;S. M. Smith

  684
  Citations

• Mechanisms involved in cartilage proteoglycan catabolism.

  Bruce Caterson;Carl R. Flannery;Clare Elizabeth Hughes;Chris B. Little

  403
  Citations

• n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation *

  Clare L. Curtis;Clare Elizabeth Hughes;C. R. Flannery;Chris B. Little

  382
  Citations

• Post-traumatic osteoarthritis: from mouse models to clinical trials

  Christopher B. Little;David J. Hunter

  293
  Citations

• Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

  Chris B. Little;Carl R. Flannery;Clare E. Hughes;John S. Mort

  259
  Citations

• Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

  Clare L. Curtis;Sarah G. Rees;Chris B. Little;Carl R. Flannery

  244
  Citations

• Proteoglycan degradation by the ADAMTS family of proteinases.

  Heather Stanton;James Melrose;Christopher B. Little;Amanda J. Fosang

  241
  Citations

• Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

  Christopher B. Little;Clare T. Meeker;Suzanne B. Golub;Kate E. Lawlor

  236
  Citations

• Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

  B.Y. Chan;E.S. Fuller;A.K. Russell;S.M. Smith

  210
  Citations

• Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis

  Allan A Young;Susan V. McLennan;Margaret M. Smith;Susan M Smith

  197
  Citations

• Histopathology atlas of animal model systems – overview of guiding principles

  T. Aigner;J.L. Cook;N. Gerwin;S.S. Glasson

  197
  Citations

• What constitutes an "animal model of osteoarthritis"--the need for consensus?

  C.B. Little;S. Zaki;S. Zaki

  195
  Citations

• Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.

  Christopher B. Little;Clare Elizabeth Hughes;Clare L. Curtis;Mike J. Janusz

  176
  Citations

• Catabolism of aggrecan, decorin and biglycan in tendon.

  Sarah G. Rees;Carl R. Flannery;Chris B. Little;Clare Elizabeth Hughes

  168
  Citations

• Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

  Carl R Flannery;Chris B Little;Bruce Caterson;Clare E Hughes

  161
  Citations

• Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

  Shireen R Lamandé;Shireen R Lamandé;Yuan Yuan;Irma L Gresshoff;Irma L Gresshoff;Lynn Rowley

  160
  Citations

• IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage.

  Carl R. Flannery;Chris B. Little;Clare Elizabeth Hughes;Clare L. Curtis

  157
  Citations