John D. Sandy

Overview

Best Publications

• Biosynthetic response of cartilage explants to dynamic compression.

  R. L.-Y. Sah;Young-Jo Kim;J.-Y. H. Doong;A. J. Grodzinsky

  1142
  Citations

• The structure of aggrecan fragments in human synovial fluid : Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

  L. Stefan Lohmander;Peter J. Neame;John D. Sandy

  641
  Citations

• The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

  J D Sandy;C R Flannery;P J Neame;L S Lohmander

  590
  Citations

• Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

  John D. Sandy;Jennifer Westling;Richard D. Kenagy;M. Luisa Iruela-Arispe

  516
  Citations

• Mechanical Regulation of Cartilage Biosynthetic Behavior: Physical Stimuli

  Young-Jo Kim;Robert L. Y. Sah;Alan J. Grodzinsky;Anna H. K. Plaas

  445
  Citations

• Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.

  J D Sandy;P J Neame;R E Boynton;C R Flannery

  400
  Citations

• Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

  C R Flannery;M W Lark;J D Sandy

  397
  Citations

• Processing and Localization of ADAMTS-1 and Proteolytic Cleavage of Versican during Cumulus Matrix Expansion and Ovulation

  Darryl L. Russell;Kari M.H. Doyle;Scott A. Ochsner;John D. Sandy

  317
  Citations

• Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy

  Laurel Ng;Alan J. Grodzinsky;Parth Patwari;John Sandy

  307
  Citations

• ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.

  Juan Carlos Rodriguez-Manzaneque;Jennifer Westling;Shelley N. M. Thai;Alfonso Luque

  290
  Citations

• Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.

  Michael W. Lark;John T. Gordy;Jeffrey R. Weidner;Julia Ayala

  285
  Citations

• Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo

  John D. Sandy;Christie Verscharen

  274
  Citations

• ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1 *

  Gui Gao;Anna H. Plaas;Vivian P. Thompson;Sue Jin

  269
  Citations

• Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components.

  W A Galloway;G Murphy;J D Sandy;J Gavrilovic

  257
  Citations

• Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants.

  Robert L-Y. Sah;Joe-Yuan H. Doong;Alan J. Grodzinsky;Anna H.K. Plaas

  249
  Citations

• In Vivo and in Vitro Stimulation of Chondrocyte Biosynthetic Activity in Early Experimental Osteoarthritis

  John D. Sandy;Mark E. Adams;Michael E. J. Billingham;Anna Plaas

  244
  Citations

• Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

  Meina Wang;Jie Shen;Hongting Jin;Hongting Jin;Hee Jeong Im

  241
  Citations

• Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.

  John D. Sandy;Dan Gamett;Vivian Thompson;Christie Verscharen

  222
  Citations

• Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

  Gui Gao;Jennifer Westling;Vivian P. Thompson;Troy D. Howell

  213
  Citations

• Changes in cartilage composition and physical properties due to stromelysin degradation.

  Lawrence J. Bonassar;Eliot H. Frank;Jane C. Murray;Claribel G. Paguio

  198
  Citations