World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
70
Citations
22712
World Ranking
20063
National Ranking
9990

Overview

Michael Brines is affiliated with the Kenneth S. Warren Institute in the United States. Their research spans multiple disciplines within the broader fields of medicine and neuroscience, with a significant focus on neurology, molecular biology, cardiology and cardiovascular medicine, endocrine and autonomic systems, and physiology.

The scientist's work prominently addresses topics including vagus nerve stimulation research, nicotinic acetylcholine receptors study, heart rate variability and autonomic control, neuroscience of respiration and sleep, erythropoietin and anemia treatment, neuroinflammation and neurodegeneration mechanisms, as well as adenosine and purinergic signaling.

Michael Brines has contributed to multiple research papers, some of the notable recent publications include:

  • HMGB1 released from nociceptors mediates inflammation, 2021, published in Proceedings of the National Academy of Sciences
  • Neurons Are a Primary Driver of Inflammation via Release of HMGB1, 2021, published in Cells
  • Control of inflammation using non-invasive neuromodulation: past, present and promise, 2021, published in International Immunology
  • Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans, 2023, published in Brain stimulation
  • Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses, 2023, published in Molecular Medicine

The frequent co-authors with whom Michael Brines collaborates include Kevin J. Tracey, Sangeeta S. Chavan, Valentin A. Pavlov, Téa Tsaava, and Aisling Tynan.

Regarding publication venues, they have multiple works appearing in bioRxiv (Cold Spring Harbor Laboratory), Molecular Medicine, Bioelectronic Medicine, Research Square, and Brain Stimulation, reflecting ongoing contributions to key journals and repositories in the relevant fields of biomedical and neuroscience research.

Best Publications

  • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.

    Michael L. Brines;Pietro Ghezzi;Sonja Keenan;Davide Agnello

  • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

    Anna Leena Sirén;Maddalena Fratelli;Michael Brines;Christoph Goemans

  • Erythropoietin therapy for acute stroke is both safe and beneficial.

    Hannelore Ehrenreich;Martin Hasselblatt;Christoph Dembowski;Lukas Cepek

  • Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

    Marcel Leist;Pietro Ghezzi;Giovanni Grasso;Giovanni Grasso;Roberto Bianchi

  • Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor

    Michael Brines;Giovanni Grasso;Giovanni Grasso;Fabio Fiordaliso;Alessandra Sfacteria

  • Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

    Laura Calvillo;Roberto Latini;Jan Kajstura;Annarosa Leri

  • Emerging biological roles for erythropoietin in the nervous system

    Michael Brines;Anthony Cerami

  • Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.

    Murat Celik;Necati Gökmen;Serhat Erbayraktar;Mustafa Akhisaroglu

  • Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis.

    Pia Villa;Paolo Bigini;Tiziana Mennini;Davide Agnello

  • Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury

    Anna K. Junk;Antonios Mammis;Sean I. Savitz;Manjeet Singh

  • Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

    Serhat Erbayraktar;Giovanni Grasso;Giovanni Grasso;Alessandra Sfacteria;Alessandra Sfacteria;Qiao wen Xie

  • Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma.

    Alfredo Gorio;Necati Gokmen;Serhat Erbayraktar;Osman Yilmaz

  • Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis

    Davide Agnello;Paolo Bigini;Pia Villa;Tiziana Mennini

  • Erythropoietin as an antiapoptotic, tissue-protective cytokine

    P Ghezzi;M Brines

  • An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

    Mohammad Asif;John Egan;Sara Vasan;Garikiparthy N. Jyothirmayi

  • Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response.

    M. Brines;A. Cerami

  • Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise.

    M Brines;A Cerami

  • Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

    Michael Brines;Nimesh S.A. Patel;Pia Villa;Courtenay Brines

  • Erythropoietin both protects from and reverses experimental diabetic neuropathy.

    Roberto Bianchi;Belgin Buyukakilli;Michael Brines;Costanza Savino

  • A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.

    Peter V. Vaitkevicius;Mark Lane;Harold Spurgeon;Donald K. Ingram

Frequent Co-Authors

Anthony Cerami
Anthony Cerami Araim Pharmaceuticals (United States)
Pietro Ghezzi
Pietro Ghezzi Brighton and Sussex Medical School
Albert Dahan
Albert Dahan Leiden University Medical Center
Rayaz A. Malik
Rayaz A. Malik Weill Cornell Medical College in Qatar
Christoph Thiemermann
Christoph Thiemermann Queen Mary University of London
Alan W. Stitt
Alan W. Stitt Queen's University Belfast
Marcel Leist
Marcel Leist University of Konstanz
Edward G. Lakatta
Edward G. Lakatta National Institutes of Health
Roberto Latini
Roberto Latini Mario Negri Institute for Pharmacological Research
Martin L. Yarmush
Martin L. Yarmush Rutgers, The State University of New Jersey

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