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Biology and Biochemistry

D-Index
60
Citations
12624
World Ranking
11974
National Ranking
5140

Overview

Constance Tom Noguchi is affiliated with the National Institutes of Health in the United States and has a research focus primarily within the field of Medicine. Their work spans several subfields including Hematology, Genetics, Physiology, Oncology, and Endocrine and Autonomic Systems. The main topics covered in their research include erythropoietin and anemia treatment, hemoglobinopathies and related disorders, PARP inhibition in cancer therapy, mesenchymal stem cell research, adipose tissue and metabolism, pharmacological effects and toxicity studies, and erythrocyte function and pathophysiology.

They have contributed to a number of research articles published in various scientific journals. Recent publications include:

  • The Many Facets of Erythropoietin Physiologic and Metabolic Response, 2020, Frontiers in Physiology
  • Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis, 2020, The FASEB Journal
  • Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity, 2020, International Journal of Molecular Sciences
  • Erythropoietin Non-hematopoietic Tissue Response and Regulation of Metabolism During Diet Induced Obesity, 2021, Frontiers in Pharmacology
  • Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation, 2020, JCI Insight

They frequently collaborate with other researchers, with notable coauthors including Jee-Young Lee, Sukanya Suresh, Heather Rogers, Praveen Kumar Rajvanshi, and Soumyadeep Dey. Their research is often featured in prominent venues such as Frontiers in Physiology, Diabetes, Frontiers in Cell and Developmental Biology, The FASEB Journal, and the International Journal of Molecular Sciences.

  • Frontiers in Physiology
  • Diabetes
  • Frontiers in Cell and Developmental Biology
  • The FASEB Journal
  • International Journal of Molecular Sciences

Their work involves detailed exploration of erythropoietin's physiological and metabolic roles as well as its involvement in bone formation and metabolism, including investigations in mouse models of obesity. These studies contribute to an understanding of erythropoietin's function beyond hematopoiesis, addressing its impact on metabolism and tissue responses in various contexts.

Best Publications

  • Erythropoietin receptor mRNA expression in human endothelial cells.

    Athanasius Anagnostou;Ziyao Liu;Manfred Steiner;Kyung Chin

  • Erythropoietin receptor signalling is required for normal brain development

    Xiaobing Yu;John J. Shacka;Jeffrey B. Eells;Carlos Suarez-Quian

  • Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells

    Bojana B. Beleslin-Cokic;Vladan P. Cokic;Xiaobing Yu;Babette B. Weksler

  • Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea.

    Griffin P. Rodgers;George J. Dover;Constance Tom Noguchi;Alan N. Schechter

  • Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts

    Martha Ogilvie;Xiaobing Yu;Valerie Nicolas-Metral;Silvia M. Pulido

  • 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

    Timothy J. Ley;Timothy J. Ley;Joseph DeSimone;Joseph DeSimone;Constance Tom Noguchi;Constance Tom Noguchi;Patricia H. Turner;Patricia H. Turner

  • Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease

    Griffin P. Rodgers;George J. Dover;Nobuhiro Uyesaka;Constance T. Noguchi

  • Levels of fetal hemoglobin necessary for treatment of sickle cell disease.

    Constance Tom Noguchi;Griffin P. Rodgers;Graham Serjeant;Alan N. Schechter

  • Role of erythropoietin in the brain

    Constance Tom Noguchi;Pundit Asavaritikrai;Ruifeng Teng;Yi Jia

  • Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

    Lewis L. Hsu;Lewis L. Hsu;Hunter C. Champion;Sally A. Campbell-Lee;Trinity J. Bivalacqua

  • The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease

    Constance Tom Noguchi;Alan N. Schechter

  • Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation

    Zhi Yong Chen;Pundit Asavaritikrai;Josef T. Prchal;Constance Tom Noguchi

  • Regulated Human Erythropoietin Receptor Expression in Mouse Brain

    Chun Liu;Kun Shen;Ziyao Liu;Constance Tom Noguchi

  • Production and processing of erythropoietin receptor transcripts in brain.

    Kyung Chin;Xiaobing Yu;Bojana Beleslin-Cokic;Chun Liu

  • The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo.

    Stephen H. Embury;Neil M. Matsui;Sahana Ramanujam;Tanya N. Mayadas

  • Periodic microcirculatory flow in patients with sickle-cell disease

    Griffin P. Rodgers;Alan N. Schechter;Constance T. Noguchi;Harvey G. Klein

  • The Many Facets of Erythropoietin Physiologic and Metabolic Response.

    Sukanya Suresh;Praveen Kumar Rajvanshi;Constance T. Noguchi

  • Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity

    Mark T. Gladwin;Alan N. Schechter;James H. Shelhamer;Lewis K. Pannell

  • LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis

    Xin Hu;Xingguo Li;Kristell Valverde;Xueqi Fu

  • PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

    Li Wang;Ruifeng Teng;Lijun Di;Heather Rogers

Frequent Co-Authors

Alan N. Schechter
Alan N. Schechter National Institute of Diabetes and Digestive and Kidney Diseases
Mark T. Gladwin
Mark T. Gladwin University of Pittsburgh
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Max Gassmann
Max Gassmann University of Zurich
Raj K. Puri
Raj K. Puri US Food and Drug Administration
Michael Chopp
Michael Chopp Oakland University
Susan F. Leitman
Susan F. Leitman National Institutes of Health
Oksana Gavrilova
Oksana Gavrilova National Institutes of Health
Gregory J. Kato
Gregory J. Kato CSL Behring
Narla Mohandas
Narla Mohandas New York Blood Center

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