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Gregory J. Kato

Gregory J. Kato

D-Index & Metrics

Medicine

D-Index
76
Citations
19763
World Ranking
18834
National Ranking
9387

Overview

Gregory J. Kato is a researcher affiliated with CSL Behring in the United States, specializing primarily in the field of medicine with a focus on genetics, hematology, molecular biology, physiology, and child health. Their scholarly work extensively explores hemoglobinopathies and related disorders, iron metabolism and disorders, erythrocyte function and pathophysiology, and the role of heme oxygenase-1 and carbon monoxide. Additional research topics include epigenetics and DNA methylation, blood groups and transfusion, as well as hemoglobin structure and function.

The scientist has contributed to numerous publications in notable venues, particularly in the areas of hematology and related biomedical research. Frequent publication outlets include:

  • Blood
  • American Journal of Hematology
  • Frontiers in Immunology
  • Journal of sickle cell disease.
  • American Journal of Physiology-Cell Physiology

Kato has collaborated with a number of co-authors on research projects, with frequent collaborators including Mark T. Gladwin, Victor R. Gordeuk, Mehdi Nouraie, Prithu Sundd, and Caterina P. Minniti. These collaborations have contributed to an extensive body of work in the field of sickle cell disease and related topics.

Their recent published papers cover various aspects of hemoglobinopathies and sickle cell disease. Notable works include:

  • The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease, 2021, Frontiers in Immunology
  • Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease, 2021, JAMA
  • Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study, 2020, American Journal of Hematology
  • Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence, 2022, Journal of Clinical Medicine
  • Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice, 2020, Frontiers in Immunology

The overarching themes of Kato's research focus on understanding the molecular and physiological mechanisms of sickle cell disease and related blood disorders. The studies often emphasize the pathological role of free heme and iron metabolism, and investigate potential therapeutic strategies such as plasma-derived hemopexin.

Their publication record reflects a sustained engagement with the scientific community on issues related to hemoglobinopathies, employing interdisciplinary approaches from genetics to physiology and pediatrics.

Best Publications

  • Sickle cell disease

    Gregory J Kato;Frédéric B Piel;Clarice D Reid;Marilyn H Gaston

  • Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes

    Gregory J. Kato;Mark T. Gladwin;Martin H. Steinberg

  • Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.

    Claudia R. Morris;Gregory J. Kato;Mirjana Poljakovic;Xunde Wang

  • Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

    Gregory J Kato;Gregory J Kato;Gregory J Kato;Vicki R McGowan;Vicki R McGowan;Vicki R McGowan;Roberto F Machado;Roberto F Machado;Roberto F Machado;Jane A Little;Jane A Little;Jane A Little

  • Intravascular hemolysis and the pathophysiology of sickle cell disease

    Gregory J. Kato;Martin H. Steinberg;Mark T. Gladwin

  • An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

    G J Kato;J Barrett;M Villa-Garcia;C V Dang

  • Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

    José Villagra;Sruti Shiva;Lori A. Hunter;Roberto F. Machado

  • Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions.

    Gregory J. Kato;Robert P. Hebbel;Martin H. Steinberg;Mark T. Gladwin

  • Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.

    Vandana Sachdev;Roberto F. Machado;Yukitaka Shizukuda;Yesoda N. Rao

  • An Official American Thoracic Society Clinical Practice Guideline: Diagnosis, Risk Stratification, and Management of Pulmonary Hypertension of Sickle Cell Disease

    Elizabeth S. Klings;Roberto F. Machado;Robyn J. Barst;Claudia R. Morris

  • Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

    Roberto F. Machado;Robyn J. Barst;Nancy A. Yovetich;Kathryn L. Hassell

  • Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension

    Roberto F. Machado;Sabrina Martyr;Gregory J. Kato;Robyn J. Barst

  • Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis: A Randomized Controlled Trial

    Mark T. Gladwin;Gregory J. Kato;Debra Weiner;Onyinye C. Onyekwere

  • Mortality in Adults With Sickle Cell Disease and Pulmonary Hypertension

    Alem Mehari;Mark T. Gladwin;Xin Tian;Roberto F. Machado

  • N-Terminal Pro-Brain Natriuretic Peptide Levels and Risk of Death in Sickle Cell Disease

    Roberto F. Machado;Anastasia Anthi;Martin H. Steinberg;Duane Bonds

  • Levels of soluble endothelium‐derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

    Gregory J. Kato;Sabrina Martyr;William C. Blackwelder;James S. Nichols

  • Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization.

    Chi V. Dang;John Barrett;Manuel Villa-Garcia;Linda M.S. Resar

  • Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

    Caterina P. Minniti;Craig Sable;Andrew Campbell;Sohail Rana

  • Function of the c-Myc oncoprotein

    Gregory J. Kato;Chi V. Dang

  • Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins

    Chi V. Dang;Christine Dolde;Maura L. Gillison;Gregory J. Kato

Frequent Co-Authors

Mark T. Gladwin
Mark T. Gladwin University of Pittsburgh
Victor R. Gordeuk
Victor R. Gordeuk University of Illinois at Chicago
Martin H. Steinberg
Martin H. Steinberg Boston University
Robyn J. Barst
Robyn J. Barst Columbia University
Alan T. Remaley
Alan T. Remaley National Institutes of Health
Clinton T. Baldwin
Clinton T. Baldwin Boston University
J. Philip McCoy
J. Philip McCoy National Institutes of Health
Elliott Vichinsky
Elliott Vichinsky University of California, San Francisco
Chi V. Dang
Chi V. Dang University of Pennsylvania
David B. Badesch
David B. Badesch University of Colorado Denver

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