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Molecular Biology

D-Index
65
Citations
17861
World Ranking
1659
National Ranking
839

Overview

John F. Tisdale is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these areas, they have focused notably on subfields such as Genetics, Molecular Biology, Hematology, Pediatrics, Perinatology and Child Health, and Physiology.

The main research topics addressed by Tisdale include Hemoglobinopathies and Related Disorders, CRISPR and Genetic Engineering, Virus-based gene therapy research, Prenatal Screening and Diagnostics, Iron Metabolism and Disorders, Pluripotent Stem Cells Research, and Blood Groups and Transfusion.

Tisdale has contributed extensively to the scientific literature, publishing in several frequent venues. These include Blood, Transplantation and Cellular Therapy, Blood Advances, Molecular Therapy - Methods & Clinical Development, and Molecular Therapy.

Notable recent papers by Tisdale include:

  • Base editing of haematopoietic stem cells rescues sickle cell disease in mice, 2021, Nature
  • Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease, 2021, Science Translational Medicine
  • Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease, 2020, Blood Advances
  • Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice, 2023, Nature Biomedical Engineering
  • American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation, 2021, Blood Advances

Frequent co-authors collaborating with Tisdale include Naoya Uchida, Matthew M. Hsieh, Selami Demirci, Alexis Leonard, and Mark C. Walters. These collaborations have resulted in a significant number of joint publications.

Best Publications

  • Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.

    Childs R;Chernoff A;Contentin N;Bahceci E

  • Neurogenesis in the Striatum of the Adult Human Brain

    Aurélie Ernst;Kanar Alkass;Samuel Bernard;Mehran Salehpour

  • Dynamics of oligodendrocyte generation and myelination in the human brain.

    Maggie S.Y. Yeung;Sofia Zdunek;Olaf Bergmann;Samuel Bernard

  • Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease

    Matthew M. Hsieh;Elizabeth M. Kang;Courtney D. Fitzhugh;M. Beth Link

  • The Lifespan and Turnover of Microglia in the Human Brain

    Pedro Réu;Pedro Réu;Azadeh Khosravi;Samuel Bernard;Jeff E. Mold

  • Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences

    Matthew M. Hsieh;James E. Everhart;Danita D. Byrd-Holt;John F. Tisdale

  • Hepatitis-Associated Aplastic Anemia

    K E Brown;J Tisdale;A J Barrett;C E Dunbar

  • Cardiomyogenesis in the Adult Human Heart

    Jan Kajstura;Konrad Urbanek;Shira Perl;Toru Hosoda

  • Ex Vivo Expansion of Genetically Marked Rhesus Peripheral Blood Progenitor Cells Results in Diminished Long-Term Repopulating Ability

    J.F. Tisdale;Y. Hanazono;S.E. Sellers;B.A. Agricola

  • Nonmyeloablative HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Phenotype

    Matthew M. Hsieh;Courtney D. Fitzhugh;R. Patrick Weitzel;Mary E. Link

  • Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

    Wolfram Goessling;Robyn S. Allen;Xiao Guan;Ping Jin

  • Intracellular interferon-γ in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia

    Elaine Sloand;Sonnie Kim;Jaroslaw P. Maciejewski;John Tisdale

  • HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques.

    Matthew M. Hsieh;N. Seth Linde;Aisha Wynter;Mark Metzger

  • Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

    Hong Ye;Suh Young Jeong;Manik C. Ghosh;Gennadiy Kovtunovych

  • Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating

    Shira Y. Perl;J. A. Kushner;B. A. Buchholz;A. K. Meeker

  • Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

    Fabio Candotti;Kit L. Shaw;Linda Muul;Denise Carbonaro

  • Polyclonal long-term repopulating stem cell clones in a primate model.

    Manfred Schmidt;Manfred Schmidt;Manfred Schmidt;Philipp Zickler;Philipp Zickler;Philipp Zickler;Gesa Hoffmann;Gesa Hoffmann;Gesa Hoffmann;Sebastian Haas;Sebastian Haas;Sebastian Haas

  • Base editing of haematopoietic stem cells rescues sickle cell disease in mice.

    Gregory A. Newby;Gregory A. Newby;Gregory A. Newby;Jonathan S. Yen;Kaitly J. Woodard;Thiyagaraj Mayuranathan

  • Successful Treatment of Metastatic Renal Cell Carcinoma With a Nonmyeloablative Allogeneic Peripheral-Blood Progenitor-Cell Transplant: Evidence for a Graft-Versus-Tumor Effect

    Richard W. Childs;Emmanuel Clave;John Tisdale;Michelle Plante

  • Allogeneic hematopoietic stem cell transplantation for sickle cell disease: the time is now.

    Matthew M. Hsieh;Courtney D. Fitzhugh;John F. Tisdale

Frequent Co-Authors

Robert E. Donahue
Robert E. Donahue National Institutes of Health
Cynthia E. Dunbar
Cynthia E. Dunbar National Institutes of Health
Richard Childs
Richard Childs National Institutes of Health
Harry L. Malech
Harry L. Malech National Institutes of Health
Susan F. Leitman
Susan F. Leitman National Institutes of Health
Neal S. Young
Neal S. Young National Institutes of Health
Shengdar Q. Tsai
Shengdar Q. Tsai St. Jude Children's Research Hospital
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
A. John Barrett
A. John Barrett National Institutes of Health
David R. Liu
David R. Liu Broad Institute

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