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Microbiology

D-Index
83
Citations
31822
World Ranking
964
National Ranking
19

Overview

Alessandro Aiuti is affiliated with Vita-Salute San Raffaele University in Italy. Their research spans multiple intersecting fields within biomedical sciences, with a strong focus on immunology, genetics, molecular biology, infectious diseases, and physiology.

The scientist's work covers several main fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, Aiuti has contributed extensively to key subfields including:

  • Immunology
  • Genetics
  • Molecular Biology
  • Infectious Diseases
  • Physiology

The research topics addressed emphasize virus-related therapies and immune system disorders, with notable attention to advanced genetic tools and infectious viral diseases. Major topics covered include:

  • Virus-based gene therapy research
  • Immunodeficiency and Autoimmune Disorders
  • Lysosomal Storage Disorders Research
  • CAR-T cell therapy research
  • Cytomegalovirus and herpesvirus research
  • CRISPR and Genetic Engineering
  • SARS-CoV-2 and COVID-19 Research

Aiuti has published in a wide range of academic journals, with frequent appearances in:

  • Blood
  • Molecular Genetics and Metabolism
  • Journal of Clinical Immunology
  • Journal of Allergy and Clinical Immunology
  • The Journal of Experimental Medicine

Selected recent publications include:

  • "Autoantibodies against type I IFNs in patients with life-threatening COVID-19", 2020, Science
  • "Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths", 2021, Science Immunology
  • "X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19", 2021, Science Immunology
  • "Human genetic and immunological determinants of critical COVID-19 pneumonia", 2022, Nature
  • "Coronavirus disease 2019 in patients with inborn errors of immunity: An international study", 2020, Journal of Allergy and Clinical Immunology

Frequent coauthors in Aiuti's research network include:

  • Maria Pia Cicalese
  • Federica Barzaghi
  • Maria Ester Bernardo
  • Valeria Calbi
  • Luigi Naldini

Best Publications

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

    Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  • The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

    A. Aiuti;I.J. Webb;C. Bleul;T. Springer

  • A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

    Conrad C. Bleul;Robert C. Fuhlbrigge;Jose M. Casasnovas;Alessandro Aiuti

  • Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

    Alessandro Aiuti;Shimon Slavin;Memet Aker;Francesca Ficara

  • Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.

    Alessandra Biffi;Eugenio Montini;Laura Lorioli;Martina Cesani

  • Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

    Alessandro Aiuti;Luca Biasco;Samantha Scaramuzza;Francesca Ferrua

  • Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

    Alessandro Aiuti;Federica Cattaneo;Stefania Galimberti;Ulrike Benninghoff

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Human genetic and immunological determinants of critical COVID-19 pneumonia

    Unknown

  • Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial

    Maria Sessa;Laura Lorioli;Francesca Fumagalli;Serena Acquati

  • A map of human circular RNAs in clinically relevant tissues

    Philipp G. Maass;Petar Glažar;Sebastian Memczak;Gunnar Dittmar

  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

    Takaki Asano;Bertrand Boisson;Bertrand Boisson;Bertrand Boisson;Fanny Onodi;Daniela Matuozzo;Daniela Matuozzo

  • Coronavirus Disease 2019 in patients with inborn errors of immunity: an international study.

    Isabelle Meyts;Giorgia Bucciol;Isabella Quinti;Bénédicte Neven

  • Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access

    Unknown

  • Hot spots of retroviral integration in human CD34+ hematopoietic cells

    Claudia Cattoglio;Giulia Facchini;Daniela Sartori;Antonella Antonelli

  • Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

    Alessandro Aiuti;Barbara Cassani;Grazia Andolfi;Massimiliano Mirolo

  • Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

    Federica Barzaghi;Laura Cristina Amaya Hernandez;Benedicte Neven;Silvia Ricci

  • Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.

    Asbjørg Stray-Pedersen;Hanne Sørmo Sorte;Pubudu Samarakoon;Tomasz Gambin;Tomasz Gambin

  • Gene therapy for ADA‐SCID, the first marketing approval of an ex vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products

    Alessandro Aiuti;Maria Grazia Roncarolo;Luigi Naldini

  • Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome.

    Marita Bosticardo;Francesco Marangoni;Alessandro Aiuti;Alessandro Aiuti;Anna Villa

  • Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lymphohematopoietic progenitors

    Alessandro Aiuti;Manuela Tavian;Arcadi Cipponi;Francesca Ficara

  • How I treat ADA deficiency

    H. Bobby Gaspar;Alessandro Aiuti;Fulvio Porta;Fabio Candotti

Frequent Co-Authors

Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Fabio Ciceri
Fabio Ciceri Vita-Salute San Raffaele University
Claudio Bordignon
Claudio Bordignon MolMed (Italy)
Anna Villa
Anna Villa National Academies of Sciences, Engineering, and Medicine
Paolo Rossi
Paolo Rossi University of Rome Tor Vergata
Eugenio Montini
Eugenio Montini IRCCS Ospedale San Raffaele
Caterina Cancrini
Caterina Cancrini Bambino Gesù Children's Hospital
Adrian J. Thrasher
Adrian J. Thrasher University College London
Giuliana Ferrari
Giuliana Ferrari Vita-Salute San Raffaele University

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