What is he best known for?
The fields of study he is best known for:
Manfred Schmidt spends much of his time researching Genetic enhancement, Immunology, Genetics, Stem cell and Haematopoiesis.
The various areas that Manfred Schmidt examines in his Genetic enhancement study include Insertional mutagenesis, Viral vector, Severe combined immunodeficiency and Transplantation.
He has included themes like Long terminal repeat and Cell biology in his Viral vector study.
His biological study spans a wide range of topics, including T cell and Genetic transfer.
His studies deal with areas such as Hematopoietic stem cell transplantation, Cancer research and Hematopoietic stem cell as well as Immunology.
His Stem cell research incorporates elements of Primary immunodeficiency and Chronic granulomatous disease.
His most cited work include:
- LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. (3006 citations)
- Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy (1141 citations)
- Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. (1020 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Genetic enhancement, Genetics, Immunology, Viral vector and Molecular biology.
His Genetic enhancement study incorporates themes from Insertional mutagenesis, Haematopoiesis, Stem cell, Transgene and Transplantation.
His Haematopoiesis research incorporates themes from Myeloid and Wiskott–Aldrich syndrome.
He interconnects Cytotoxic T cell, Hematopoietic stem cell transplantation and Cancer research in the investigation of issues within Immunology.
While the research belongs to areas of Cancer research, Manfred Schmidt spends his time largely on the problem of Colorectal cancer, intersecting his research to questions surrounding Cell.
His Molecular biology research includes elements of Ex vivo, In vivo, Gene expression profiling, Cas9 and Long terminal repeat.
He most often published in these fields:
- Genetic enhancement (36.94%)
- Genetics (27.39%)
- Immunology (26.11%)
What were the highlights of his more recent work (between 2016-2021)?
- Gene (20.38%)
- Cell biology (15.92%)
- Genetics (27.39%)
In recent papers he was focusing on the following fields of study:
Manfred Schmidt mainly investigates Gene, Cell biology, Genetics, Computational biology and Viral vector.
In Gene, Manfred Schmidt works on issues like Haematopoiesis, which are connected to Progenitor cell and Myeloid.
His work on Plasmid, DNA sequencing and Reference genome as part of general Genetics study is frequently connected to Profiling and Scalability, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His Computational biology research also works with subjects such as
- Genome that intertwine with fields like Immunodeficiency, Primary immunodeficiency, Severe combined immunodeficiency and Transplantation,
- Sequencing data which intersects with area such as Short read and Viral gene.
His Viral vector research is multidisciplinary, incorporating elements of In utero, Factor IX, Immune tolerance, Genetic enhancement and Toxicity.
His research investigates the connection between Genetic enhancement and topics such as FANCA that intersect with problems in Cancer research.
Between 2016 and 2021, his most popular works were:
- Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia. (40 citations)
- Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration (31 citations)
- Control of chronic lymphocytic leukemia development by clonally-expanded CD8(+) T-cells that undergo functional exhaustion in secondary lymphoid tissues (31 citations)
In his most recent research, the most cited papers focused on:
Manfred Schmidt mostly deals with Cancer research, Genetics, Pandemic, Computational biology and Gene.
In his works, Manfred Schmidt undertakes multidisciplinary study on Cancer research and Population.
CRISPR, Transgene, Gene deletion, Colorectal cancer and Genetic heterogeneity are among the areas of Genetics where the researcher is concentrating his efforts.
Pandemic combines with fields such as Epidemiology, In patient, Environmental health, Anticipation and Outbreak in his investigation.
His research in Computational biology intersects with topics in Genome, Nucleus, Nuclear pore and Enhancer, Transcription.
In most of his Gene studies, his work intersects topics such as T cell.
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