Fellow of The Academy of Medical Sciences, United Kingdom
His scientific interests lie mostly in Immunology, Genetic enhancement, Cell biology, Severe combined immunodeficiency and Transplantation. His research investigates the link between Immunology and topics such as Stem cell that cross with problems in Embryonic stem cell. Adrian J. Thrasher combines subjects such as Progenitor cell, Molecular biology, Viral vector and Transgene with his study of Genetic enhancement.
His biological study spans a wide range of topics, including Transduction and Virology. The study incorporates disciplines such as Wiskott–Aldrich syndrome protein, Actin cytoskeleton, Arp2/3 complex, Wiskott–Aldrich syndrome and Retinitis pigmentosa in addition to Cell biology. The concepts of his Severe combined immunodeficiency study are interwoven with issues in Insertional mutagenesis, Natural killer cell, Leukemia and Oncology.
Adrian J. Thrasher mostly deals with Immunology, Genetic enhancement, Cell biology, Viral vector and Stem cell. His Immunology research includes elements of Wiskott–Aldrich syndrome and Transplantation. His Genetic enhancement study incorporates themes from Haematopoiesis, Cancer research, Transgene, Virology and Severe combined immunodeficiency.
Adrian J. Thrasher has researched Haematopoiesis in several fields, including Progenitor cell, CD34 and Chronic granulomatous disease. His Cell biology research is multidisciplinary, relying on both Wiskott–Aldrich syndrome protein, Podosome, Actin cytoskeleton and Cytoskeleton. His Viral vector study combines topics from a wide range of disciplines, such as Molecular biology and Transduction.
Adrian J. Thrasher focuses on Genetic enhancement, Immunology, Cell biology, Haematopoiesis and Cancer research. His Genetic enhancement study integrates concerns from other disciplines, such as CD34, Stem cell, Viral vector, Primary immunodeficiency and Transplantation. His Immunology research includes themes of Hematopoietic stem cell transplantation, Wiskott–Aldrich syndrome and Severe combined immunodeficiency.
He focuses mostly in the field of Severe combined immunodeficiency, narrowing it down to topics relating to Common gamma chain and, in certain cases, Dendritic cell. His work carried out in the field of Cell biology brings together such families of science as Cellular differentiation, T cell and Wiskott–Aldrich syndrome protein, Actin cytoskeleton, Cytoskeleton. The various areas that Adrian J. Thrasher examines in his Haematopoiesis study include Progenitor cell, Homing and Chronic granulomatous disease.
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Effect of gene therapy on visual function in Leber's congenital amaurosis.
James W B Bainbridge;Alexander J Smith;Susie S Barker;Scott Robbie.
The New England Journal of Medicine (2008)
Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy
Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud.
The New England Journal of Medicine (2002)
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Marion G Ott;Manfred Schmidt;Kerstin Schwarzwaelder;Stefan Stein.
Nature Medicine (2006)
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae.
Journal of Clinical Investigation (2008)
Adrian J. Thrasher;Nicholas H. Keep;Frans Wientjes;Anthony W. Segal.
Biochimica et Biophysica Acta (1994)
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
Stefan Stein;Marion G. Ott;Stephan Schultze-Strasser;Anna Jauch.
Nature Medicine (2010)
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
H Bobby Gaspar;Kathryn L Parsley;Steven Howe;Doug King.
The Lancet (2004)
High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
Christophe Demaison;Kathryn Parsley;Gaby Brouns;Michaela Scherr.
Human Gene Therapy (2002)
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
Waseem Qasim;Hong Zhan;Sujith Samarasinghe;Stuart Adams.
Science Translational Medicine (2017)
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Kamaljit S Balaggan;Angus MacNeil;Steven J Howe.
Nature Medicine (2006)
Profile was last updated on December 6th, 2021.
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