D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 89 Citations 27,126 284 World Ranking 429 National Ranking 39
Medicine D-index 106 Citations 38,718 431 World Ranking 2820 National Ranking 278

Research.com Recognitions

Awards & Achievements

Fellow of The Academy of Medical Sciences, United Kingdom

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Internal medicine

His scientific interests lie mostly in Immunology, Genetic enhancement, Cell biology, Severe combined immunodeficiency and Transplantation. His research investigates the link between Immunology and topics such as Stem cell that cross with problems in Embryonic stem cell. Adrian J. Thrasher combines subjects such as Progenitor cell, Molecular biology, Viral vector and Transgene with his study of Genetic enhancement.

His biological study spans a wide range of topics, including Transduction and Virology. The study incorporates disciplines such as Wiskott–Aldrich syndrome protein, Actin cytoskeleton, Arp2/3 complex, Wiskott–Aldrich syndrome and Retinitis pigmentosa in addition to Cell biology. The concepts of his Severe combined immunodeficiency study are interwoven with issues in Insertional mutagenesis, Natural killer cell, Leukemia and Oncology.

His most cited work include:

  • Effect of gene therapy on visual function in Leber's congenital amaurosis. (1589 citations)
  • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. (1020 citations)
  • Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy (977 citations)

What are the main themes of his work throughout his whole career to date?

Adrian J. Thrasher mostly deals with Immunology, Genetic enhancement, Cell biology, Viral vector and Stem cell. His Immunology research includes elements of Wiskott–Aldrich syndrome and Transplantation. His Genetic enhancement study incorporates themes from Haematopoiesis, Cancer research, Transgene, Virology and Severe combined immunodeficiency.

Adrian J. Thrasher has researched Haematopoiesis in several fields, including Progenitor cell, CD34 and Chronic granulomatous disease. His Cell biology research is multidisciplinary, relying on both Wiskott–Aldrich syndrome protein, Podosome, Actin cytoskeleton and Cytoskeleton. His Viral vector study combines topics from a wide range of disciplines, such as Molecular biology and Transduction.

He most often published in these fields:

  • Immunology (48.12%)
  • Genetic enhancement (43.99%)
  • Cell biology (27.46%)

What were the highlights of his more recent work (between 2015-2021)?

  • Genetic enhancement (43.99%)
  • Immunology (48.12%)
  • Cell biology (27.46%)

In recent papers he was focusing on the following fields of study:

Adrian J. Thrasher focuses on Genetic enhancement, Immunology, Cell biology, Haematopoiesis and Cancer research. His Genetic enhancement study integrates concerns from other disciplines, such as CD34, Stem cell, Viral vector, Primary immunodeficiency and Transplantation. His Immunology research includes themes of Hematopoietic stem cell transplantation, Wiskott–Aldrich syndrome and Severe combined immunodeficiency.

He focuses mostly in the field of Severe combined immunodeficiency, narrowing it down to topics relating to Common gamma chain and, in certain cases, Dendritic cell. His work carried out in the field of Cell biology brings together such families of science as Cellular differentiation, T cell and Wiskott–Aldrich syndrome protein, Actin cytoskeleton, Cytoskeleton. The various areas that Adrian J. Thrasher examines in his Haematopoiesis study include Progenitor cell, Homing and Chronic granulomatous disease.

Between 2015 and 2021, his most popular works were:

  • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells (444 citations)
  • Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy (189 citations)
  • The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity (123 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Effect of gene therapy on visual function in Leber's congenital amaurosis.

James W B Bainbridge;Alexander J Smith;Susie S Barker;Scott Robbie.
The New England Journal of Medicine (2008)

2123 Citations

Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy

Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud.
The New England Journal of Medicine (2002)

1350 Citations

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

Marion G Ott;Manfred Schmidt;Kerstin Schwarzwaelder;Stefan Stein.
Nature Medicine (2006)

1215 Citations

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae.
Journal of Clinical Investigation (2008)

1179 Citations

CHRONIC GRANULOMATOUS-DISEASE

Adrian J. Thrasher;Nicholas H. Keep;Frans Wientjes;Anthony W. Segal.
Biochimica et Biophysica Acta (1994)

811 Citations

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

Stefan Stein;Marion G. Ott;Stephan Schultze-Strasser;Anna Jauch.
Nature Medicine (2010)

762 Citations

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

H Bobby Gaspar;Kathryn L Parsley;Steven Howe;Doug King.
The Lancet (2004)

756 Citations

High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

Christophe Demaison;Kathryn Parsley;Gaby Brouns;Michaela Scherr.
Human Gene Therapy (2002)

680 Citations

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Waseem Qasim;Hong Zhan;Sujith Samarasinghe;Stuart Adams.
Science Translational Medicine (2017)

567 Citations

Effective gene therapy with nonintegrating lentiviral vectors

Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Kamaljit S Balaggan;Angus MacNeil;Steven J Howe.
Nature Medicine (2006)

520 Citations

Best Scientists Citing Adrian J. Thrasher

Axel Schambach

Axel Schambach

Hannover Medical School

Publications: 141

Alain Fischer

Alain Fischer

Collège de France

Publications: 135

William W. Hauswirth

William W. Hauswirth

University of Florida

Publications: 107

Christopher Baum

Christopher Baum

Hannover Medical School

Publications: 102

Andrew R. Gennery

Andrew R. Gennery

Boston Children's Hospital

Publications: 100

Jean-Laurent Casanova

Jean-Laurent Casanova

Rockefeller University

Publications: 98

Robin R. Ali

Robin R. Ali

King's College London

Publications: 98

Alessandro Aiuti

Alessandro Aiuti

Vita-Salute San Raffaele University

Publications: 97

Donald B. Kohn

Donald B. Kohn

University of California, Los Angeles

Publications: 93

Capucine Picard

Capucine Picard

Necker-Enfants Malades Hospital

Publications: 79

Katherine A. High

Katherine A. High

Children's Hospital of Philadelphia

Publications: 76

Hans Peter Kiem

Hans Peter Kiem

Fred Hutchinson Cancer Research Center

Publications: 74

Simon N. Waddington

Simon N. Waddington

University College London

Publications: 74

Luigi Naldini

Luigi Naldini

Vita-Salute San Raffaele University

Publications: 73

Jean Bennett

Jean Bennett

University of Pennsylvania

Publications: 70

Manfred Schmidt

Manfred Schmidt

German Cancer Research Center

Publications: 70

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

If you think any of the details on this page are incorrect, let us know.

Contact us
Something went wrong. Please try again later.