World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
122
Citations
52404
World Ranking
322
National Ranking
27

Medicine

D-Index
124
Citations
53917
World Ranking
3237
National Ranking
327

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Adrian J. Thrasher is affiliated with University College London in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine. The main fields of study include Genetics, Molecular Biology, Immunology, Oncology, and Physiology.

The scientist's work addresses key topics such as:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • CRISPR and Genetic Engineering
  • Hemoglobinopathies and Related Disorders
  • Immunodeficiency and Autoimmune Disorders
  • RNA Interference and Gene Delivery
  • Acute Lymphoblastic Leukemia research

Recent notable papers featuring Adrian J. Thrasher include:

  • Gene therapy using haematopoietic stem and progenitor cells, 2020, Nature Reviews Genetics
  • Lentiviral gene therapy for X-linked chronic granulomatous disease, 2020, Nature Medicine
  • Betibeglogene Autotemcel Gene Therapy for Non-β 00 Genotype β-Thalassemia, 2021, New England Journal of Medicine
  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency, 2021, New England Journal of Medicine
  • Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients, 2021, Nature Cancer

Frequent coauthors in their publications include Claire Booth, Giorgia Santilli, Franco Locatelli, Marina Cavazzana, and Suradej Hongeng, indicating ongoing collaborations in related research areas.

Adrian J. Thrasher's work is often published in specialized scientific venues with a high concentration of their research appearing in Blood, Transplantation and Cellular Therapy, Human Gene Therapy, Molecular Therapy - Methods & Clinical Development, and Molecular Therapy.

They have been recognized as a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • Effect of gene therapy on visual function in Leber's congenital amaurosis.

    James W B Bainbridge;Alexander J Smith;Susie S Barker;Scott Robbie

  • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

    Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae

  • Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy

    Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud

  • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

    Marion G Ott;Manfred Schmidt;Kerstin Schwarzwaelder;Stefan Stein

  • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

    Waseem Qasim;Hong Zhan;Sujith Samarasinghe;Stuart Adams

  • Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

    Stefan Stein;Marion G. Ott;Stephan Schultze-Strasser;Anna Jauch

  • Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

    H Bobby Gaspar;Kathryn L Parsley;Steven Howe;Doug King

  • A robust model for read count data in exome sequencing experiments and implications for copy number variant calling

    Vincent Plagnol;James Curtis;Michael Epstein;Kin Y. Mok

  • The cytoplasm of living cells behaves as a poroelastic material

    Emad Moeendarbary;Léo Valon;Léo Valon;Marco Fritzsche;Marco Fritzsche;Andrew R. Harris;Andrew R. Harris

  • High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

    Christophe Demaison;Kathryn Parsley;Gaby Brouns;Michaela Scherr

  • Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy

    Florian Eichler;Christine Duncan;Patricia L. Musolino;Paul J. Orchard

  • The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity

    Markus G. Seidel;Gerhard Kindle;Benjamin Gathmann;Isabella Quinti

  • Effective gene therapy with nonintegrating lentiviral vectors

    Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Rafael J Yáñez-Muñoz;Kamaljit S Balaggan;Angus MacNeil;Steven J Howe

  • Whole-genome sequencing of patients with rare diseases in a national health system.

    E Turro;W J Astle;W J Astle;K Megy;S Gräf

  • The Wiskott-Aldrich syndrome.

    Hans D. Ochs;Adrian J. Thrasher

  • Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

    K J Carss;G Arno;M Erwood;J Stephens

  • Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

    Capucine Picard;Capucine Picard;Horst Von Bernuth;Horst Von Bernuth;Horst Von Bernuth;Pegah Ghandil;Pegah Ghandil;Pegah Ghandil;Maya Chrabieh;Maya Chrabieh

  • WASP: a key immunological multitasker

    Adrian J. Thrasher;Siobhan O. Burns;Siobhan O. Burns

  • Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

    Ute Modlich;Susana Navarro;Daniela Zychlinski;Tobias Maetzig

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • Efficacy of gene therapy for X-linked severe combined immunodeficiency: update on trial No.1 follow-up and preliminary results of multicentric collaborative trial No. 2 (Paris - Boston - London)

    S Hacein-Bey-Abina;L Caccaveli;F Touzot;L Dal-Cortivo

Frequent Co-Authors

Siobhan O. Burns
Siobhan O. Burns University College London
Christine Kinnon
Christine Kinnon University College London
Robin R. Ali
Robin R. Ali King's College London
Kimberly Gilmour
Kimberly Gilmour Great Ormond Street Hospital
Simon N. Waddington
Simon N. Waddington University College London
H. Bobby Gaspar
H. Bobby Gaspar Great Ormond Street Hospital
Axel Schambach
Axel Schambach Hannover Medical School
Austen Worth
Austen Worth Great Ormond Street Hospital
David A. Williams
David A. Williams Boston Children's Hospital
Gareth E. Jones
Gareth E. Jones King's College London

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