His scientific interests lie mostly in Genetic enhancement, Immunology, Molecular biology, Virology and Transduction. His Genetic enhancement research includes themes of Immune tolerance, Antibody, Viral vector and Transgene. His biological study spans a wide range of topics, including Stem cell and Immune system.
Simon N. Waddington has researched Immunology in several fields, including Stem cell transplantation for articular cartilage repair, Neurodegeneration, Mesenchymal stem cell, Cell biology and Clotting factor. His study in Molecular biology is interdisciplinary in nature, drawing from both In vivo, Crosstalk, Notch signaling pathway, Jagged-1 Protein and Gene delivery. His work on Virus and Liver infection as part of general Virology study is frequently linked to Serine protease and Coxsackievirus, therefore connecting diverse disciplines of science.
His main research concerns Genetic enhancement, Immunology, Transgene, Viral vector and Cell biology. His Genetic enhancement study combines topics from a wide range of disciplines, such as Bioinformatics, In utero, Fetus, Vector and Pathology. The concepts of his Immunology study are interwoven with issues in Factor IX and Stem cell.
His work is dedicated to discovering how Transgene, Molecular biology are connected with In vivo and other disciplines. His research in Viral vector intersects with topics in Adeno-associated virus, Virology, Andrology, Reporter gene and Bioluminescence imaging. Simon N. Waddington has included themes like Luciferase and Gene, Transduction in his Cell biology study.
His primary areas of study are Genetic enhancement, Viral vector, Cell biology, Transgene and Gene delivery. The study incorporates disciplines such as Bioinformatics, In utero, Disease, Pathology and Virus in addition to Genetic enhancement. His Viral vector research is multidisciplinary, relying on both Virology, Vector, Andrology, Nitric oxide and Bioluminescence imaging.
His work carried out in the field of Vector brings together such families of science as Toxicity and Immune tolerance. The various areas that Simon N. Waddington examines in his Cell biology study include Luciferase, Gene expression, Transduction and Adeno-associated virus. His Gene delivery research incorporates elements of Haemophilia B and Immunology.
Simon N. Waddington mainly focuses on Genetic enhancement, Cell biology, Pathology, In utero and Virus. The Genetic enhancement study combines topics in areas such as Haemophilia B, Neurodegeneration, Transduction and Virology. His Cell biology research integrates issues from Induced pluripotent stem cell and Hepatocyte.
In his work, Viral vector, Factor IX and Toxicity is strongly intertwined with Immunology, which is a subfield of In utero. His studies in Virus integrate themes in fields like Cancer research, Antibody, Adeno-associated virus and Central nervous system. His research investigates the link between Haemophilia A and topics such as Vector that cross with problems in Transgene.
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Adenovirus serotype 5 hexon mediates liver gene transfer
Simon N. Waddington;John H. McVey;David Bhella;Alan L. Parker.
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver
Amit C. Nathwani;John T. Gray;Catherine Y. C. Ng;Junfang Zhou.
Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes
Alan L. Parker;Simon N. Waddington;Campbell G. Nicol;Dmitry M. Shayakhmetov.
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.
Amit C Nathwani;Amit C Nathwani;Cecilia Rosales;Jenny McIntosh;Ghasem Rastegarlari.
Molecular Therapy (2011)
Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.
Laura D. Osellame;Ahad A. Rahim;Iain P. Hargreaves;Matthew E. Gegg;Matthew E. Gegg.
Cell Metabolism (2013)
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Mike Themis;Simon N. Waddington;Manfred Schmidt;Christof von Kalle;Christof von Kalle.
Molecular Therapy (2005)
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.
Jenny McIntosh;Jenny McIntosh;Peter J. Lenting;Cecilia Rosales;Cecilia Rosales;Doyoung Lee.
Stable gene transfer to muscle using non-integrating lentiviral vectors.
Luis Apolonia;Simon N Waddington;Carolina Fernandes;Natalie J Ward.
Molecular Therapy (2007)
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Raul Alba;Angela C. Bradshaw;Alan L. Parker;David Bhella.
Codon optimization of human factor VIII cDNAs leads to high-level expression
Natalie J. Ward;Suzanne M. K. Buckley;Simon N. Waddington;Thierry VandenDriessche;Thierry VandenDriessche.
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