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Biology and Biochemistry

D-Index
65
Citations
14672
World Ranking
9175
National Ranking
703

Overview

Paul Gissen is affiliated with University College London in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable volume of publications reflecting these areas of expertise.

Their work covers several subfields including Physiology, Molecular Biology, Genetics, Rheumatology, and Clinical Biochemistry. These diverse subfields contribute to a broad understanding of molecular and physiological processes in health and disease.

The main topics of their research include:

  • Lysosomal Storage Disorders Research
  • Glycogen Storage Diseases and Myoclonus
  • Metabolism and Genetic Disorders
  • Virus-based gene therapy research
  • Cellular transport and secretion
  • Parkinson's Disease Mechanisms and Treatments
  • Amino Acid Enzymes and Metabolism

Frequent publication venues for Paul Gissen include:

  • Molecular Genetics and Metabolism
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Orphanet Journal of Rare Diseases
  • Journal of Inherited Metabolic Disease
  • Cell Death and Differentiation

Paul Gissen has collaborated with a number of researchers frequently, including:

  • Angela Schulz
  • Julien Baruteau
  • Nicola Specchio
  • Philippa B. Mills
  • Emily de los Reyes

Some of the recent publications associated with Paul Gissen are:

  • Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation, 2020, Cell Death and Differentiation
  • Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity, 2022, Nature Neuroscience
  • Genomic investigations of unexplained acute hepatitis in children, 2023, Nature
  • Clinical applications for exosomes: Are we there yet?, 2021, British Journal of Pharmacology
  • Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities, 2020, Annals of Neurology

Best Publications

  • Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy

    Florian Eichler;Christine Duncan;Patricia L. Musolino;Paul J. Orchard

  • PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron

    Neil V Morgan;Shawn K Westaway;Jenny E V Morton;Allison Gregory

  • α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

    Marthe H. R. Ludtmann;Marthe H. R. Ludtmann;Plamena R. Angelova;Mathew H. Horrocks;Mathew H. Horrocks;Minee L. Choi;Minee L. Choi

  • Study of Intraventricular Cerliponase Alfa for CLN2 Disease.

    Angela Schulz;Temitayo Ajayi;Nicola Specchio;Emily de Los Reyes

  • Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

    Emma Deas;Nunilo Cremades;Plamena R. Angelova;Marthe H.R. Ludtmann

  • The monoamine neurotransmitter disorders: an expanding range of neurological syndromes

    Manju A Kurian;Manju A Kurian;Paul Gissen;Paul Gissen;Martin Smith;Simon Jr Heales

  • α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca 2+ homeostasis and mitochondrial ATP production

    Sébastien Paillusson;Patricia Gomez-Suaga;Radu Stoica;Daniel Little

  • Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome

    P Gissen;P Gissen;C A Johnson;N Morgan;J M Stapelbroek

  • The transmembrane protein meckelin ( MKS3 ) is mutated in Meckel-Gruber syndrome and the wpk rat

    Ursula M Smith;Mark Consugar;Louise J Tee;Brandy M McKee

  • Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.

    Karin Tuschl;Esther Meyer;Leonardo E Valdivia;Ningning Zhao

  • Structural and functional hepatocyte polarity and liver disease.

    Paul Gissen;Paul Gissen;Paul Gissen;Irwin M. Arias

  • Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

    Plamena R. Angelova;Minee L. Choi;Minee L. Choi;Alexey V. Berezhnov;Mathew H. Horrocks;Mathew H. Horrocks

  • Phenotypic spectrum of neurodegeneration associated with mutations in the PLA2G6 gene (PLAN)

    M. A. Kurian;N. V. Morgan;L. MacPherson;K. Foster

  • Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.

    Manju A. Kurian;Juan Zhen;Shu-Yuan Cheng;Yan Li

  • Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome

    Irene A Aligianis;Colin A Johnson;Paul Gissen;Dongrong Chen

  • Consensus clinical management guidelines for Niemann-Pick disease type C.

    Tarekegn Geberhiwot;Alessandro Moro;Andrea Dardis;Uma Ramaswami

  • Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia

    Esther Meyer;Keren J Carss;Keren J Carss;Julia Rankin;John M E Nichols

  • Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study.

    Manju A. Kurian;Manju A. Kurian;Yan Li;Juan Zhen;Esther Meyer

  • Mutations in SLC29A3, Encoding an Equilibrative Nucleoside Transporter ENT3, Cause a Familial Histiocytosis Syndrome (Faisalabad Histiocytosis) and Familial Rosai-Dorfman Disease

    Neil V. Morgan;Mark R. Morris;Hakan Cangul;Hakan Cangul;Diane Gleeson

  • Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome

    Philippa B. Mills;Stephane S.M. Camuzeaux;Emma J. Footitt;Emma J. Footitt;Kevin A. Mills

Frequent Co-Authors

Eamonn R. Maher
Eamonn R. Maher University of Cambridge
Manju A. Kurian
Manju A. Kurian University College London
Peter E. Clayton
Peter E. Clayton University of Manchester
Neil V. Morgan
Neil V. Morgan University of Birmingham
Simon N. Waddington
Simon N. Waddington University College London
Simon J. R. Heales
Simon J. R. Heales University College London
Colin A. Johnson
Colin A. Johnson University of Leeds
Nicola Specchio
Nicola Specchio Boston Children's Hospital
Deirdre A. Kelly
Deirdre A. Kelly University of Birmingham
Steve P. Watson
Steve P. Watson University of Birmingham

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