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Biology and Biochemistry

D-Index
57
Citations
12181
World Ranking
13801
National Ranking
5839

Overview

Howard G. Shertzer is affiliated with the University of Cincinnati in the United States. Their research spans multiple fields including Nursing, Neuroscience, and Medicine, with a focus on Nutrition and Dietetics, Developmental Neuroscience, and Neurology as subfields.

Their main topics of work involve Vitamin C and Antioxidants Research, Anesthesia and Neurotoxicity Research, and Alcoholism and Thiamine Deficiency.

Among recent publications, one paper is titled Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis, published in 2023 in the journal Antioxidants. This paper has received citations and contributes to the study of antioxidant mechanisms in neurological conditions.

Frequent coauthors working with Howard G. Shertzer include:

  • Ying Chen
  • Katherine D. Holland
  • Daniel W. Nebert
  • Timothy P. Dalton

Their work has appeared primarily in the journal Antioxidants, reflecting a concentration in research related to oxidative stress and related biochemical pathways.

Best Publications

  • REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

    Timothy P. Dalton;Howard G. Shertzer;Alvaro Puga

  • Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehyde.

    Albert P. Senft;Timothy P. Dalton;Howard G. Shertzer

  • Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescin

    Huan Zhu;Gerard L. Bannenberg;Peter Moldéus;Howard G. Shertzer

  • Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

    Shigeyuki Uno;Timothy P. Dalton;Sandrine Derkenne;Christine P. Curran

  • Genetically altered mice to evaluate glutathione homeostasis in health and disease.

    Timothy P. Dalton;Ying Chen;Scott N. Schneider;Daniel W. Nebert

  • alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.

    Ana Luisa Kadekaro;Renny Kavanagh;Hiromi Kanto;Silva Terzieva

  • Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse: novel model system for a severely compromised oxidative stress response

    Yi Yang;Matthew Z. Dieter;Ying Chen;Howard G. Shertzer

  • Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

    Shigeyuki Uno;Timothy P. Dalton;Nadine Dragin;Christine P. Curran

  • Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

    Timothy P. Dalton;Matthew Z. Dieter;Yi Yang;Howard G. Shertzer

  • Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

    Ying Chen;Howard G. Shertzer;Scott N. Schneider;Daniel W. Nebert

  • Glutathione defense mechanism in liver injury: insights from animal models

    Y. Chen;H. Dong;D.C. Thompson;H.G. Shertzer

  • Induction of cellular oxidative stress by aryl hydrocarbon receptor activation.

    Timothy P Dalton;Alvaro Puga;Howard G Shertzer

  • Dioxin causes a sustained oxidative stress response in the mouse.

    Howard G. Shertzer;Daniel W. Nebert;Alvaro Puga;Michelle Ary

  • Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor.

    Albert P Senft;Timothy P Dalton;Daniel W Nebert;Mary Beth Genter

  • Glutathione redox state regulates mitochondrial reactive oxygen production.

    Dongxiao Shen;Timothy P. Dalton;Daniel W. Nebert;Howard G. Shertzer

  • Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure.

    Ying Chen;Yi Yang;Marian L. Miller;Dongxiao Shen

  • Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin.

    Alvaro Puga;Amy Hoffer;Shaoying Zhou;Jeanne M Bohm

  • Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.

    Timothy P. Dalton;Matthew Z. Dieter;Robin S. Matlib;Nicole L. Childs

  • Metalloproteinases Mediate Mucin 5AC Expression by Epidermal Growth Factor Receptor Activation

    Hitesh S. Deshmukh;Lisa M. Case;Scott C. Wesselkamper;Michael T. Borchers

  • Dioxin Increases Reactive Oxygen Production in Mouse Liver Mitochondria

    Albert P. Senft;Timothy P. Dalton;Daniel W. Nebert;Mary Beth Genter

Frequent Co-Authors

Daniel W. Nebert
Daniel W. Nebert University of Cincinnati
Timothy P. Dalton
Timothy P. Dalton University of Cincinnati
Alvaro Puga
Alvaro Puga University of Cincinnati Medical Center
Vasilis Vasiliou
Vasilis Vasiliou Yale University
Peter Moldéus
Peter Moldéus Karolinska Institute
George D. Leikauf
George D. Leikauf University of Pittsburgh
Mary F. Mahon
Mary F. Mahon University of Bath
Deborah J. Clegg
Deborah J. Clegg Cedars-Sinai Medical Center
Ying Xia
Ying Xia Fudan University
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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