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Genetics

D-Index
69
Citations
13962
World Ranking
2374
National Ranking
298

Overview

Volker M. Arlt is affiliated with King's College London in the United Kingdom and conducts research primarily within the domain of biochemistry, genetics, and molecular biology. Their work spans multiple subfields, including molecular biology, pharmacology, cancer research, aging, and toxicology related to health and mutagenesis.

The scientist has contributed to a significant number of publications, with a total of 20 papers in their main field of study. Their research topics include genetics, aging, and longevity in model organisms, carcinogens and genotoxicity assessment, pharmacogenetics and drug metabolism, nephrotoxicity and medicinal plants, drug-induced hepatotoxicity and protection, potato plant research, and plant pathogens and resistance.

Volker M. Arlt's recent publications illustrate a focus on genotoxicity, molecular toxicology, and carcinogenicity mechanisms. Some notable papers include:

  • Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis, 2021, published in Mutagenesis
  • Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts, 2020, published in Archives of Toxicology
  • Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway, 2021, published in Archives of Toxicology
  • Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats, 2021, published in International Journal of Molecular Sciences
  • Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes, 2021, published in International Journal of Molecular Sciences

The scientist frequently publishes in specialized journals such as Environmental and Molecular Mutagenesis, International Journal of Molecular Sciences, Mutagenesis, Archives of Toxicology, and Chemical Research in Toxicology. Among these, Environmental and Molecular Mutagenesis is the most frequent venue with eight publications.

Throughout their career, Volker M. Arlt has collaborated often with several other researchers, including:

  • David H. Phillips
  • Francesco Marchetti
  • Stephanie L. Smith-Roe
  • Janice M. Pluth
  • B. Bhaskar Gollapudi

These collaborations span multiple projects reflecting diverse interests in toxicology and molecular mechanisms related to DNA damage and repair, carcinogen exposure, and genetic toxicology. The scientist's interdisciplinary approach integrates molecular biology techniques and toxicological assessments to explore the effects of various environmental and chemical agents on genetic material.

Best Publications

  • Urothelial Carcinoma Associated with the Use of a Chinese Herb (Aristolochia fangchi)

    J L Nortier;M C Martinez;H H Schmeiser;Volker Arlt

  • Aristolochic acid as a probable human cancer hazard in herbal remedies a review

    Volker M Arlt;Marie Stiborova;Heinz H Schmeiser

  • A Compendium of Mutational Signatures of Environmental Agents

    Jill E. Kucab;Xueqing Zou;Xueqing Zou;Sandro Morganella;Madeleine Joel

  • The 32P-postlabeling assay for DNA adducts.

    David H Phillips;Volker M Arlt

  • Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: Characterization of the process and possible mechanisms involved

    Eleonora Longhin;Jørn Andreas Holme;Kristine Bjerve Gutzkow;Volker Arlt

  • Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer

    Volker M. Arlt;Marie Stiborová;Jochen vom Brocke;Maria L. Simões

  • The genome as a record of environmental exposure

    Serena Nik-Zainal;Jill E. Kucab;Sandro Morganella;Dominik Glodzik

  • The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.

    M Refik Gökmen;Jean-Pierre Cosyns;Volker M Arlt;Marie Stiborová

  • DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.

    Graham M. Lord;Monica Hollstein;Volker M. Arlt;Candice Roufosse

  • Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo(a)pyrene, dibenzo(def,p)chrysene and three environmental mixtures in the FVB/N mouse

    Lisbeth K. Siddens;Andrew Larkin;Sharon K. Krueger;Christopher A. Bradfield

  • SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest)

    Sebastian Kevekordes;Volker Mersch-Sundermann;Christian M Burghaus;Jan Spielberger

  • Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

    Volker M Arlt;Hansruedi Glatt;Eva Muckel;Ulrike Pabel

  • 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.

    Volker M. Arlt

  • Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

    Volker M. Arlt;Marie Stiborova;Colin J. Henderson;Martin R. Osborne

  • Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

    Volker M. Arlt;Marie Stiborová;Colin J. Henderson;Markus Thiemann

  • Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

    Catherine Lebeau;Frédéric D. Debelle;Volker M. Arlt;Agnieszka Pozdzik

  • DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.

    Nan Mei;Volker M. Arlt;David H. Phillips;Robert H. Heflich

  • Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

    Marie Stiborová;Eva Frei;Volker M. Arlt;Heinz H. Schmeiser

  • Genotoxicity: damage to DNA and its consequences.

    David H. Phillips;Volker M. Arlt

  • Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells

    J Ovrevik;Volker Arlt;E Oya;Eszter Nagy

Frequent Co-Authors

David H. Phillips
David H. Phillips King's College London
Marie Stiborová
Marie Stiborová Charles University
Heinz H. Schmeiser
Heinz H. Schmeiser German Cancer Research Center
Eva Frei
Eva Frei Charles University
Monica Hollstein
Monica Hollstein University of Leeds
Colin J. Henderson
Colin J. Henderson University of Dundee
C. Roland Wolf
C. Roland Wolf University of Dundee
Jørn A. Holme
Jørn A. Holme Norwegian Institute of Public Health
Manfred Wiessler
Manfred Wiessler German Cancer Research Center
Albrecht Seidel
Albrecht Seidel Johannes Gutenberg University of Mainz

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