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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
35299
World Ranking
1746
National Ranking
112

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 1995 - Fellow of the Royal Society of Edinburgh

Overview

C. Roland Wolf is affiliated with the University of Dundee in the United Kingdom. Their scholarly work spans several subfields, including Molecular Biology, Health, Toxicology and Mutagenesis, Pharmacology, Computational Theory and Mathematics, and Oncology.

Their research covers diverse topics such as Computational Drug Discovery Methods, Pharmacogenetics and Drug Metabolism, Melanoma and MAPK Pathways, Glutathione Transferases and Polymorphisms, Genomics, phytochemicals, and oxidative stress, Effects and risks of endocrine disrupting chemicals, and Arsenic contamination and mitigation.

Wolf has contributed to multiple peer-reviewed publications. Notable papers include:

  • "Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism" (2022, Drug Metabolism Reviews)
  • "Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2" (2021, Redox Biology)
  • "Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity" (2020, Environmental Pollution)
  • "Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism" (2024, Proceedings of the National Academy of Sciences)
  • "Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling" (2021, British Journal of Cancer)

Their research has been featured in several publication venues, with frequent contributions to Zeitschrift für Arbeitsrecht, bioRxiv (Cold Spring Harbor Laboratory), F1000Research, Drug Metabolism Reviews, and Redox Biology.

Wolf has collaborated extensively within the scientific community. Frequent co-authors include Colin J. Henderson, Francisco Iñesta-Vaquera, Yury Kapelyukh, Aileen McLaren, and Febe Ferro.

Among their distinctions, Wolf was awarded the title of Fellow of the Royal Society of Edinburgh in 1995.

Best Publications

  • Regulation of JNK signaling by GSTp

    Victor Adler;Zhimin Yin;Serge Y. Fuchs;Miriam Benezra

  • Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.

    L. W. Harries;M. J. Stubbins;D. Forman;G. C. W. Howard

  • The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

    Michael McMahon;Ken Itoh;Masayuki Yamamoto;Simon A. Chanas

  • NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES

    B Mannervik;Y C Awasthi;P G Board;J D Hayes

  • Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

    Gillian Smith;Francis A. Carey;Julie Beattie;Murray J. V. Wilkie

  • Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.

    M.Danny Burke;Stephanie Thompson;Richard J. Weaver;C.Roland Wolf

  • Nomenclature for human CYP2D6 alleles.

    A K Daly;J Brockmoller;F Broly;M Eichelbaum

  • Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

    Simon A Chanas;Qing Jiang;Michael McMahon;Gail K McWalter

  • Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.

    D Ryberg;V Skaug;A Hewer;D H Phillips

  • Feedback control of AHR signalling regulates intestinal immunity.

    Chris Schiering;Emma Wincent;Amina Metidji;Andrea Iseppon

  • Discovery of common and rare genetic risk variants for colorectal cancer

    Jeroen R. Huyghe;Stephanie A. Bien;Tabitha A. Harrison;Hyun Min Kang

  • Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

    C J Henderson;A G Smith;J Ure;K Brown

  • The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.

    J. D. Hayes;S. A. Chanas;C.J. Henderson;M. McMahon

  • Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

    Xiu Jun Wang;John D. Hayes;C. Roland Wolf

  • A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.

    Christoph Sachse;Gillian Smith;Murray J.V. Wilkie;Jennifer H. Barrett

  • The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.

    Helen Vosper;Lisa Patel;Tracey L. Graham;Guennadi A. Khoudoli

  • Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Xiu Jun Wang;John D. Hayes;Colin J. Henderson;C. Roland Wolf

  • Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

    A. F. Howie;L. M. Forrester;M. J. Glancey;J. J. Schlager

  • Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

    A D Lewis;J D Hayes;C R Wolf

  • Discovery of common and rare genetic risk variants for colorectal cancer

    Jeroen R. Huyghe;Stephanie A. Bien;Tabitha A. Harrison;Hyun Min Kang

Frequent Co-Authors

Colin J. Henderson
Colin J. Henderson University of Dundee
Mark J. I. Paine
Mark J. I. Paine Liverpool School of Tropical Medicine
Gordon C. K. Roberts
Gordon C. K. Roberts University of Leicester
John D. Hayes
John D. Hayes University of Dundee
Marie Stiborová
Marie Stiborová Charles University
Volker M. Arlt
Volker M. Arlt King's College London
Richard R. Meehan
Richard R. Meehan University of Edinburgh
David H. Phillips
David H. Phillips King's College London
Colin N. A. Palmer
Colin N. A. Palmer University of Dundee
Michael Schwarz
Michael Schwarz Helmholtz Center for Information Security

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