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Genetics

D-Index
66
Citations
15045
World Ranking
2620
National Ranking
334

Overview

Richard R. Meehan is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with particular attention to several subfields including Molecular Biology, Immunology, Genetics, Health, Toxicology and Mutagenesis, and Cancer Research.

The scientist's work covers key topics such as Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, Cancer, Hypoxia, and Metabolism, Immune cells in cancer, Cancer-related gene regulation, and Cancer Research and Treatments.

Richard R. Meehan has published in multiple venues, with frequent contributions to Cell Metabolism, BMC Biology, iScience, Nature, and Nucleic Acids Research.

  • Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis (2020, Cell Metabolism)
  • Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells (2020, BMC Biology)
  • Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis (2021, Cell Metabolism)
  • A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis (2020, iScience)
  • Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes (2020, Nucleic Acids Research)

The scientist has collaborated frequently with several coauthors, including John P. Thomson, Donncha S. Dunican, Sari Pennings, Pranvera Sadiku, and Joseph Willson.

Best Publications

  • Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

    Joe D. Lewis;Joe D. Lewis;Richard R. Meehan;Richard R. Meehan;William J. Henzel;Ingrid Maurer-Fogy

  • Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

    Richard R. Meehan;Joe D. Lewis;Joe D. Lewis;Stewart McKay;Elke L. Kleiner

  • Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

    Xinsheng Nan;Richard R. Meehan;Adrian Bird

  • Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

    Richard Meehan;Joe D. Lewis;Adrian P. Bird

  • Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

    Alexander Raven;Wei-Yu Lu;Tak Yung Man;Sofia Ferreira-Gonzalez

  • Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

    Colm E. Nestor;Raffaele Ottaviano;James Reddington;Duncan Sproul

  • Senescent cells harbour features of the cancer epigenome

    Hazel A Cruickshanks;Hazel A Cruickshanks;Tony McBryan;David M Nelson;Nathan D Vanderkraats

  • A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins.

    Sally H. Cross;Richard R. Meehan;Xinsheng Nan;Adrian Bird

  • Effect of Limited DNA Methylation Reprogramming in the Normal Sheep Embryo on Somatic Cell Nuclear Transfer

    Nathalie Beaujean;Nathalie Beaujean;Jane Taylor;John Gardner;Ian Wilmut

  • Non-conservation of mammalian preimplantation methylation dynamics

    Nathalie Beaujean;Nathalie Beaujean;Geraldine Hartshorne;Jennifer Cavilla;Jane Taylor

  • Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA.

    Colm Nestor;Alexey Ruzov;Richard R. Meehan;Donncha S. Dunican

  • Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

    James P Reddington;Sara M Perricone;Colm E Nestor;Colm E Nestor;Judith Reichmann

  • Retraction: Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos

    Irina Stancheva;Richard R. Meehan

  • Modules, networks and systems medicine for understanding disease and aiding diagnosis

    Mika Gustafsson;Colm E. Nestor;Huan Zhang;Albert-Laszlo Barabasi

  • A Mutant Form of MeCP2 Protein Associated with Human Rett Syndrome Cannot Be Displaced from Methylated DNA by Notch in Xenopus Embryos.

    Irina Stancheva;Anne L. Collins;Ingatia B. Van den Veyver;Huda Zoghbi;Huda Zoghbi

  • Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

    Colm E Nestor;Colm E Nestor;Raffaele Ottaviano;Diana Reinhardt;Hazel A Cruickshanks

  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.

    Richard Meehan;D P Barlow;R E Hill;B L Hogan

  • Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

    Duncan Sproul;Robert R Kitchen;Robert R Kitchen;Colm E Nestor;J Michael Dixon

  • Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer

    Duncan Sproul;Colm Nestor;Jayne Culley;Jacqueline H. Dickson

  • Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

    John J. Cole;Neil A. Robertson;Mohammed Iqbal Rather;John P. Thomson

Frequent Co-Authors

Adrian Bird
Adrian Bird University of Edinburgh
David J. Harrison
David J. Harrison University of St Andrews
C. Roland Wolf
C. Roland Wolf University of Dundee
Wendy A. Bickmore
Wendy A. Bickmore University of Edinburgh
Mikael Benson
Mikael Benson Linköping University
Jose L. Garcia-Perez
Jose L. Garcia-Perez University of Granada
Stephen M. Anderton
Stephen M. Anderton University of Edinburgh
Ian Wilmut
Ian Wilmut University of Edinburgh
Michael E. Talkowski
Michael E. Talkowski Harvard University

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