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Molecular Biology

D-Index
48
Citations
18130
World Ranking
2657
National Ranking
205

Overview

Brian Hendrich is affiliated with the University of Cambridge in the United Kingdom. Their research primarily falls within the broad discipline of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as the main subfield, supported by additional work in Biophysics, Radiology, Nuclear Medicine and Imaging, Immunology, and Organic Chemistry.

The scientist's work is concentrated on several key topics, including:

  • Genomics and Chromatin Dynamics
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • Advanced Fluorescence Microscopy Techniques
  • Advanced biosensing and bioanalysis techniques
  • Monoclonal and Polyclonal Antibodies Research
  • Advanced Biosensing Techniques and Applications

Brian Hendrich has published extensively, with notable venues including bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Nature Structural & Molecular Biology, Zenodo (CERN European Organization for Nuclear Research), and Molecular Cell.

Selected recent publications by Brian Hendrich include:

  • Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD, 2023, Nature Structural & Molecular Biology
  • Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency, 2024, Molecular Cell
  • Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by the nucleosome remodelling and deacetylation complex, 2020, Stem Cell Research
  • The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells, 2023, Biology Open

Frequent collaborators of Brian Hendrich include Nicola Reynolds, Ramy Ragheb, Ernest D. Laue, David Lando, and Dominic Hall. These coauthors have contributed to multiple projects, indicating ongoing research partnerships.

Best Publications

  • Identification and characterization of a family of mammalian methyl-CpG binding proteins.

    Brian Hendrich;Adrian Bird

  • A mouse Mecp2-null mutation causes neurological symptoms that mimic rett syndrome

    Jacky Guy;Brian Hendrich;Megan Holmes;Joanne E Martin

  • The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus.

    Carolyn J. Brown;Brian D. Hendrich;Jim L. Rupert;Ronald G. Lafreniere

  • Dynamic reprogramming of DNA methylation in the early mouse embryo.

    Fátima Santos;Brian Hendrich;Wolf Reik;Wendy Dean

  • MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.

    Huck-Hui Ng;Yi Zhang;Brian Hendrich;Colin A Johnson

  • 3D structures of individual mammalian genomes studied by single-cell Hi-C

    Tim J. Stevens;Tim J. Stevens;David Lando;Srinjan Basu;Liam P. Atkinson

  • The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

    Brian Hendrich;Ulrike Hardeland;Huck-Hui Ng;Josef Jiricny

  • The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

    Anna Prokhortchouk;Brian Hendrich;Helle Jørgensen;Alexei Ruzov

  • Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development

    Brian Hendrich;Jacqueline Guy;Bernard Ramsahoye;Valerie A. Wilson

  • The methyl-CpG binding domain and the evolving role of DNA methylation in animals.

    Brian Hendrich;Susan Tweedie

  • The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.

    Keisuke Kaji;Isabel Martín Caballero;Ruth MacLeod;Jennifer Nichols

  • Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

    Catherine B. Millar;Jacky Guy;Owen J. Sansom;Jim Selfridge

  • A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation.

    Plenge Rm;Hendrich Bd;Schwartz C;Arena Jf

  • NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

    Nicola Reynolds;Mali Salmon-Divon;Mali Salmon-Divon;Heidi Dvinge;Heidi Dvinge;Antony Hynes-Allen

  • Gene silencing quantitatively controls the function of a developmental trans-activator.

    Anne S Hutchins;Alan C Mullen;Hubert W Lee;Kara J Sykes

  • NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment

    Nicola Reynolds;Paulina Latos;Antony Hynes-Allen;Antony Hynes-Allen;Remco Loos

  • Deficiency of Mbd2 suppresses intestinal tumorigenesis

    Owen J. Sansom;Jennifer Berger;Stefan Mark Bishop;Brian Hendrich

  • Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

    Keisuke Kaji;Jennifer Nichols;Brian Hendrich

  • Kaiso-Deficient Mice Show Resistance to Intestinal Cancer

    Anna Prokhortchouk;Owen J. Sansom;Jim Selfridge;Isabel M. Caballero

  • MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner.

    Rodrigo L. dos Santos;Rodrigo L. dos Santos;Luca Tosti;Aliaksandra Radzisheuskaya;Isabel M. Caballero

Frequent Co-Authors

Adrian Bird
Adrian Bird University of Edinburgh
Paul Bertone
Paul Bertone University of Cambridge
Michiel Vermeulen
Michiel Vermeulen Radboud University
Sabine Dietmann
Sabine Dietmann University of Cambridge
Ernest D. Laue
Ernest D. Laue University of Cambridge
Huntington F. Willard
Huntington F. Willard Duke University
Ben Lehner
Ben Lehner Wellcome Sanger Institute
Carolyn J. Brown
Carolyn J. Brown University of British Columbia
Owen J. Sansom
Owen J. Sansom University of Glasgow
Sten Eirik W. Jacobsen
Sten Eirik W. Jacobsen University of Oxford

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