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Genetics

D-Index
65
Citations
18502
World Ranking
2680
National Ranking
89

Overview

Carolyn J. Brown is affiliated with the University of British Columbia in Canada. Their research activity is primarily situated within the broad field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology and Genetics. The scholar's work extends to several specialized areas, including Pediatrics, Perinatology and Child Health, Rheumatology, and Cancer Research.

The main topics explored in Carolyn J. Brown's research include the genetic and clinical aspects of sex determination and chromosomal abnormalities, genomics and chromatin dynamics, and epigenetics and DNA methylation. Additional areas of research interest are RNA modifications and cancer, CRISPR and genetic engineering, RNA research and splicing, and prenatal screening and diagnostics.

Carolyn J. Brown has published extensively in numerous scholarly journals, with frequent appearances in venues such as bioRxiv (Cold Spring Harbor Laboratory), Epigenetics & Chromatin, and Human Molecular Genetics. Other publication venues include Biology of Sex Differences and the American Journal of Medical Genetics Part C Seminars in Medical Genetics.

Some notable recent publications by Carolyn J. Brown are:

  • Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism (2020, UNC Libraries)
  • Genes that escape from X-chromosome inactivation: Potential contributors to Klinefelter syndrome (2020, American Journal of Medical Genetics Part C Seminars in Medical Genetics)
  • A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta (2021, Biology of Sex Differences)
  • Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing (2021, Epigenetics & Chromatin)
  • Independent domains for recruitment of PRC1 and PRC2 by human XIST (2021, PLoS Genetics)

Throughout their career, Carolyn J. Brown has collaborated frequently with researchers such as María José Navarro-Cobos, Bradley P. Balaton, Amy M. Inkster, Allison Matthews, and Wendy P. Robinson.

Best Publications

  • The functional role of long non-coding RNA in human carcinomas

    Ewan A Gibb;Carolyn J Brown;Wan L Lam

  • A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

    Carolyn J. Brown;Andrea Ballabio;James L. Rupert;Ronald G. Lafreniere

  • The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus.

    Carolyn J. Brown;Brian D. Hendrich;Jim L. Rupert;Ronald G. Lafreniere

  • A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules.

    Brunella Franco;Silvana Guioli;Antonella Pragliola;Antonella Pragliola;Barbara Incerti

  • A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome

    Kendy K. Wong;Ronald J. deLeeuw;Nirpjit S. Dosanjh;Lindsey R. Kimm

  • Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

    E Magda Price;E Magda Price;Allison M Cotton;Lucia L Lam;Pau Farré

  • Localization of the X inactivation centre on the human X chromosome in Xq13

    Carolyn J. Brown;Ronald G. Lafreniere;Vicki E. Powers;Gianfranco Sebastio

  • Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.

    C J Brown;S J Goss;D B Lubahn;D R Joseph

  • Human Cancer Long Non-Coding RNA Transcriptomes

    Ewan A. Gibb;Ewan A. Gibb;Emily A. Vucic;Emily A. Vucic;Katey S. S. Enfield;Katey S. S. Enfield;Greg L. Stewart;Greg L. Stewart

  • Translating dosage compensation to trisomy 21

    Jun Jiang;Yuanchun Jing;Gregory J. Cost;Jen Chieh Chiang

  • The human X-inactivation centre is not required for maintenance of X-chromosome inactivation.

    Carolyn J. Brown;Huntington F. Willard

  • The interleukin-2 receptor γ chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1

    Jennifer M. Puck;Suzanne M. Deschenes;Joanne C. Porter;Amalla S. Dutra

  • Silencing of the mammalian X chromosome.

    Jennifer C. Chow;Ziny Yen;Sonia M. Ziesche;Carolyn J. Brown

  • Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation

    Allison M. Cotton;Allison M. Cotton;E. Magda Price;E. Magda Price;Meaghan J. Jones;Meaghan J. Jones;Bradley P. Balaton;Bradley P. Balaton

  • Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis

    K-John J. Cheung;Nathalie A. Johnson;Joslynn G. Affleck;Tesa Severson

  • A stain upon the silence: genes escaping X inactivation

    Carolyn J. Brown;John M. Greally

  • Derivation of consensus inactivation status for X-linked genes from genome-wide studies

    Bradley P. Balaton;Allison M. Cotton;Carolyn J. Brown

  • Epigenomics: mapping the methylome.

    Ian M. Wilson;Jonathan J. Davies;Michael Weber;Carolyn J. Brown

  • The dynamics of X-inactivation skewing as women age.

    C Hatakeyama;C L Anderson;C L Beever;M S Peñaherrera

  • Expression of Genes from the Human Active and Inactive X Chromosomes

    Carolyn J. Brown;Laura Carrel;Huntington F. Willard

Frequent Co-Authors

Wendy P. Robinson
Wendy P. Robinson University of British Columbia
Wan L. Lam
Wan L. Lam BC Cancer Research Centre
Huntington F. Willard
Huntington F. Willard Duke University
Michael S. Kobor
Michael S. Kobor University of British Columbia
Jeanne B. Lawrence
Jeanne B. Lawrence University of Massachusetts Chan Medical School
Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia
Stephen Lam
Stephen Lam University of British Columbia
Douglas E. Horsman
Douglas E. Horsman University of British Columbia
Randy D. Gascoyne
Randy D. Gascoyne BC Cancer Agency
Marco A. Marra
Marco A. Marra University of British Columbia

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