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Genetics

D-Index
82
Citations
27269
World Ranking
1465
National Ranking
188

Research.com Recognitions

  • 2018 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Neil Brockdorff is affiliated with the University of Oxford in the United Kingdom. Their research centers primarily in the fields of biochemistry, genetics, and molecular biology, with significant contributions specifically in molecular biology. Their work intersects with related subfields including cancer research, plant science, genetics, and ecology.

The main topics covered in Neil Brockdorff's research include RNA modifications and cancer, RNA research and splicing, cancer-related molecular mechanisms, RNA and protein synthesis mechanisms, CRISPR and genetic engineering, genomics and chromatin dynamics, and genetic and clinical aspects of sex determination and chromosomal abnormalities.

Among their recent publications are:

  • Progress toward understanding chromosome silencing by Xist RNA, 2020, Genes & Development
  • Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading, 2021, Science
  • Acute depletion of METTL3 implicates N 6-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome, 2021, Genome Research
  • Locus-specific expression of transposable elements in single cells with CELLO-seq, 2021, Nature Biotechnology
  • The many faces of Polycomb regulation by RNA, 2020, Current Opinion in Genetics & Development

They have published in several venues, with frequent publications appearing in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • Science
  • Genome Research

Neil Brockdorff collaborates extensively with other researchers, including Guifeng Wei, Tatyana B. Nesterova, Joseph S. Bowness, Heather Coker, and Mafalda Almeida.

The scientist has been recognized by several awards and honors, including being named a Fellow of the Royal Society, United Kingdom in 2018. They are also a member of the European Molecular Biology Organization (EMBO) and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Requirement for Xist in X chromosome inactivation

    Graeme D. Penny;Graham F. Kay;Graham F. Kay;Steven A. Sheardown;Sohaila Rastan;Sohaila Rastan

  • The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.

    Neil Brockdorff;Alan Ashworth;Graham F. Kay;Veronica M. McCabe

  • Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation

    Mariana de Napoles;Jacqueline E. Mermoud;Rika Wakao;Y.Amy Tang

  • The interplay of histone modifications – writers that read

    Tianyi Zhang;Sarah Cooper;Neil Brockdorff

  • Establishment of Histone H3 Methylation on the Inactive X Chromosome Requires Transient Recruitment of Eed-Enx1 Polycomb Group Complexes

    Jose Silva;Winifred Mak;Ilona Zvetkova;Ruth Appanah

  • Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

    Neil P. Blackledge;Anca M. Farcas;Takashi Kondo;Hamish W. King

  • Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

    Julie K. Stock;Sara Giadrossi;Miguel Casanova;Emily Brookes

  • Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome

    Neil Brockdorff;Alan Ashworth;Graham F. Kay;Penny Cooper

  • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.

    Bradley S Cobb;Tatyana Nesterova;Elizabeth A. Thompson;Arnulf Hertweck

  • RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

    Lígia Tavares;Emilia Dimitrova;David Oxley;Judith Webster

  • Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

    Antoine H F M Peters;Jacqueline E Mermoud;Dónal O'Carroll;Dónal O'Carroll;Michaela Pagani

  • Reactivation of the Paternal X Chromosome in Early Mouse Embryos

    Winifred Mak;Tatyana B. Nesterova;Mariana de Napoles;Ruth Appanah

  • Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

    Andrei Kuzmichev;Raphael Margueron;Alejandro Vaquero;Tanja S. Preissner

  • Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

    Graham F. Kay;Graeme D. Penny;Dipika Patel;Alan Ashworth

  • KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas;Neil P Blackledge;Ian Sudbery;Hannah K Long;Hannah K Long

  • Considerations when investigating lncRNA function in vivo

    Andrew R Bassett;Asifa Akhtar;Denise P Barlow;Adrian P Bird

  • The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

    Yuko Hasegawa;Neil Brockdorff;Shinji Kawano;Kimiko Tsutui

  • SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.

    Marnie E Blewitt;Anne-Valerie Gendrel;Zhenyi Pang;Duncan B Sparrow

  • Noncoding RNA and Polycomb recruitment

    Neil Brockdorff

  • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

    David Landeira;Stephan P A Sauer;Raymond Poot;Maria Dvorkina

Frequent Co-Authors

Tatyana B. Nesterova
Tatyana B. Nesterova University of Oxford
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences
Amanda G. Fisher
Amanda G. Fisher University of Oxford
Edith Heard
Edith Heard Collège de France
Lothar Schermelleh
Lothar Schermelleh University of Oxford
Chris P. Ponting
Chris P. Ponting University of Edinburgh
Arie P. Otte
Arie P. Otte University of Amsterdam
Elizabeth M. C. Fisher
Elizabeth M. C. Fisher University College London
Matthias Merkenschlager
Matthias Merkenschlager Imperial College London
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford

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