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Biology and Biochemistry

D-Index
63
Citations
13753
World Ranking
10244
National Ranking
687

Overview

Katsuhiko Yanagisawa is affiliated with the Japan Society for the Promotion of Science in Japan. Their primary research focus lies in the field of Medicine, with notable work spanning several subfields including Physiology, Biomaterials, Surgery, Psychiatry and Mental Health, and Molecular Biology.

The main topics covered in their research include:

  • Alzheimer's disease research and treatments
  • Supramolecular Self-Assembly in Materials
  • Dementia and Cognitive Impairment Research
  • Glycosylation and Glycoproteins Research
  • Knee injuries and reconstruction techniques
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Protein Structure and Dynamics

Yanagisawa has contributed to multiple recent papers, including:

  • "Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease," 2020, Journal of Alzheimer s Disease
  • "The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization," 2023, ACS Chemical Neuroscience
  • "Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils," 2024, Journal of the American Chemical Society
  • "The double-layered structure of amyloid-β assemblage on GM1-containing membranes catalytically promotes fibrillization," 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • "Prevention of amyloid β fibril deposition on the synaptic membrane in the precuneus by ganglioside nanocluster-targeting inhibitors," 2024, RSC Chemical Biology

Frequent co-authors appearing alongside Yanagisawa include:

  • Naoki Kaneko
  • Takashi Kato
  • Yutaka Arahata
  • Shinichi Iwamoto
  • Kengo Ito

Yanagisawa's work has been published in various scientific venues, with repeated contributions to:

  • Alzheimer s & Dementia
  • Journal of Alzheimer s Disease
  • ACS Chemical Neuroscience
  • Journal of the American Chemical Society
  • RSC Chemical Biology

Best Publications

  • High performance plasma amyloid-β biomarkers for Alzheimer’s disease

    Akinori Nakamura;Naoki Kaneko;Victor L Villemagne;Takashi Kato

  • GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

    Katsuhiko Yanagisawa;Asano Odaka;Nobuhiro Suzuki;Yasuo Ihara

  • Cholesterol-dependent Formation of GM1 Ganglioside-bound Amyloid β-Protein, an Endogenous Seed for Alzheimer Amyloid *

    Atsuko Kakio;Sei-ichi Nishimoto;Katsuhiko Yanagisawa;Yasunori Kozutsumi

  • Interactions of Amyloid β-Protein with Various Gangliosides in Raft-Like Membranes: Importance of GM1 Ganglioside-Bound Form as an Endogenous Seed for Alzheimer Amyloid†

    Atsuko Kakio;Sei-ichi Nishimoto;Katsuhiko Yanagisawa;Yasunori Kozutsumi

  • A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

    Kun Zou;Jian-Sheng Gong;Katsuhiko Yanagisawa;Makoto Michikawa

  • A Seed for Alzheimer Amyloid in the Brain

    Hideki Hayashi;Nobuyuki Kimura;Haruyasu Yamaguchi;Kazuhiro Hasegawa

  • Aβ polymerization through interaction with membrane gangliosides

    Katsumi Matsuzaki;Koichi Kato;Koichi Kato;Katsuhiko Yanagisawa

  • Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture.

    Makoto Michikawa;Qi‐Wen Fan;Ichiro Isobe;Katsuhiko Yanagisawa

  • High performance plasma amyloid-beta biomarkers for Alzheimer's disease

    Akinori Nakamura;Naoki Kaneko;Victor L Villemagne;Takashi Kato

  • Apolipoprotein E (ApoE) Isoform-dependent Lipid Release from Astrocytes Prepared from Human ApoE3 and ApoE4 Knock-in Mice

    Jian Sheng Gong;Mariko Kobayashi;Hideki Hayashi;Kun Zou

  • Altered Cholesterol Metabolism in Niemann-Pick Type C1 Mouse Brains Affects Mitochondrial Function

    Wenxin Yu;Jian-Sheng Gong;Mihee Ko;William S. Garver

  • Role of gangliosides in Alzheimer’s disease

    Katsuhiko Yanagisawa

  • Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

    Soyon Hong;Beth L. Ostaszewski;Ting Yang;Tiernan T. O’Malley

  • Angiotensin-Converting Enzyme Converts Amyloid β-Protein 1–42 (Aβ1–42) to Aβ1–40, and Its Inhibition Enhances Brain Aβ Deposition

    Kun Zou;Haruyasu Yamaguchi;Hiroyasu Akatsu;Takaaki Sakamoto

  • Amyloid β-protein (Aβ)1–40 protects neurons from damage induced by Aβ1–42 in culture and in rat brain

    Kun Zou;Daesung Kim;Atsuko Kakio;Kyunghee Byun

  • A Novel Action of Alzheimer's Amyloid β-Protein (Aβ): Oligomeric Aβ Promotes Lipid Release

    Makoto Michikawa;Jian Sheng Gong;Qi Wen Fan;Naoya Sawamura

  • Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death.

    Makoto Michikawa;Katsuhiko Yanagisawa

  • Amyloid beta-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels.

    Yasuhisa Shinkai;Masahiro Yoshimura;Yuji Ito;Asano Odaka

  • Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.

    Qi-Wen Fan;Wei Yu;Takao Senda;Katsuhiko Yanagisawa

  • Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture.

    Tetsuya Mizuno;Makoto Nakata;Hironobu Naiki;Makoto Michikawa

Frequent Co-Authors

Makoto Michikawa
Makoto Michikawa Nagoya City University
Katsumi Matsuzaki
Katsumi Matsuzaki Kyoto University
Koichi Tanaka
Koichi Tanaka Shimadzu Corp
Victor L. Villemagne
Victor L. Villemagne University of Pittsburgh
Takashi Kato
Takashi Kato Nagoya University
Colin L. Masters
Colin L. Masters University of Melbourne
Kengo Ito
Kengo Ito Nagoya University
Yasuo Ihara
Yasuo Ihara Doshisha University
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Christopher C. Rowe
Christopher C. Rowe University of Melbourne

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