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Makoto Michikawa

Makoto Michikawa

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9639
World Ranking
16697
National Ranking
1195

Overview

Makoto Michikawa is affiliated with Nagoya City University in Japan and has an extensive research portfolio primarily focused on medicine and neuroscience. Their work spans several interrelated fields such as physiology, neurology, molecular biology, biological psychiatry, and cellular and molecular neuroscience.

Their main research topics center on Alzheimer's disease research and treatments, with significant contributions to understanding tryptophan's role in brain disorders, neuroinflammation and neurodegeneration mechanisms, dementia and cognitive impairment, gut microbiota and health, neurological disease mechanisms and treatments, as well as oral microbiology and periodontitis research.

Some of their recent publications include:

  • Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial, 2024, Alzheimer's & Dementia
  • Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type Mice, 2022, Nutrients
  • Cholesterol Regulates Exosome Release in Cultured Astrocytes, 2021, Frontiers in Immunology
  • Oral dysfunctions and cognitive impairment/dementia, 2020, Journal of Neuroscience Research
  • Current Biomarkers for Alzheimer's Disease: From CSF to Blood, 2020, Journal of Personalized Medicine

Throughout their career, Michikawa has frequently published in scientific journals such as the Journal of Alzheimer's Disease, Alzheimer's & Dementia, Nutrients, the International Journal of Molecular Sciences, and Frontiers in Aging Neuroscience. These venues reflect their focus on neurodegenerative diseases and related biological processes.

Collaborations have been an important aspect of their research activities. Frequent co-authors include Mona Abdelhamid, Chunyu Zhou, Cha-Gyun Jung, Kun Zou, and Tomohisa Nakamura. These partnerships suggest a multidisciplinary approach to tackling complex neurological conditions, particularly Alzheimer's disease.

Best Publications

  • A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

    Kun Zou;Jian-Sheng Gong;Katsuhiko Yanagisawa;Makoto Michikawa

  • Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.

    Kazuchika Nishitsuji;Takashi Hosono;Toshiyuki Nakamura;Guojun Bu

  • A Seed for Alzheimer Amyloid in the Brain

    Hideki Hayashi;Nobuyuki Kimura;Haruyasu Yamaguchi;Kazuhiro Hasegawa

  • Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture.

    Makoto Michikawa;Qi‐Wen Fan;Ichiro Isobe;Katsuhiko Yanagisawa

  • Apolipoprotein E (ApoE) Isoform-dependent Lipid Release from Astrocytes Prepared from Human ApoE3 and ApoE4 Knock-in Mice

    Jian Sheng Gong;Mariko Kobayashi;Hideki Hayashi;Kun Zou

  • Altered Cholesterol Metabolism in Niemann-Pick Type C1 Mouse Brains Affects Mitochondrial Function

    Wenxin Yu;Jian-Sheng Gong;Mihee Ko;William S. Garver

  • Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons.

    Owada K;Sanjo N;Kobayashi T;Mizusawa H

  • Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture.

    M. Michikawa;S. Kikuchi;H. Muramatsu;T. Muramatsu

  • Angiotensin-Converting Enzyme Converts Amyloid β-Protein 1–42 (Aβ1–42) to Aβ1–40, and Its Inhibition Enhances Brain Aβ Deposition

    Kun Zou;Haruyasu Yamaguchi;Hiroyasu Akatsu;Takaaki Sakamoto

  • Amyloid β-protein (Aβ)1–40 protects neurons from damage induced by Aβ1–42 in culture and in rat brain

    Kun Zou;Daesung Kim;Atsuko Kakio;Kyunghee Byun

  • Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

    Naoyuki Ishida;Yuichi Ishihara;Kazuto Ishida;Hiroyuki Tada

  • A Novel Action of Alzheimer's Amyloid β-Protein (Aβ): Oligomeric Aβ Promotes Lipid Release

    Makoto Michikawa;Jian Sheng Gong;Qi Wen Fan;Naoya Sawamura

  • R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.

    Tomoyuki Kamata;Ken-ichi Katsube;Makoto Michikawa;Masahito Yamada

  • Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death.

    Makoto Michikawa;Katsuhiko Yanagisawa

  • Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.

    Qi-Wen Fan;Wei Yu;Takao Senda;Katsuhiko Yanagisawa

  • Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture.

    Tetsuya Mizuno;Makoto Nakata;Hironobu Naiki;Makoto Michikawa

  • Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease?

    Makoto Michikawa

  • Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells.

    Toshiyuki Nakamura;Atsushi Watanabe;Takahiro Fujino;Takashi Hosono

  • Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice.

    Naoya Sawamura;Jian Sheng Gong;William S. Garver;Randall A. Heidenreich

  • Cholesterol‐dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons

    Qi Wen Fan;Wei Yu;Jian Sheng Gong;Kun Zou

Frequent Co-Authors

Katsuhiko Yanagisawa
Katsuhiko Yanagisawa Japan Society for the Promotion of Science
Seung U. Kim
Seung U. Kim University of British Columbia
Tetsuya Mizuno
Tetsuya Mizuno Nagoya University
Shinji Yokoyama
Shinji Yokoyama Chubu University
Toshiharu Suzuki
Toshiharu Suzuki Hokkaido University
Hidehiro Mizusawa
Hidehiro Mizusawa Tokyo Medical and Dental University
Takashi Muramatsu
Takashi Muramatsu Nagoya University
Noriyuki Matsukawa
Noriyuki Matsukawa Nagoya City University
James G. McLarnon
James G. McLarnon University of British Columbia
Tony Wyss-Coray
Tony Wyss-Coray Stanford University

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