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Toshiharu Suzuki

Toshiharu Suzuki

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15143
World Ranking
6435
National Ranking
418

Overview

Toshiharu Suzuki is affiliated with Hokkaido University in Japan and has an extensive research portfolio primarily focused on Alzheimer's disease and related neurological conditions. Their work spans multiple disciplines including medicine, biochemistry, genetics, molecular biology, and neuroscience.

The major themes in Suzuki's research include Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, genetics and neurodevelopmental disorders, cellular transport and secretion, nuclear receptors and signaling, and fatty acid research and health.

Suzuki's publications highlight involvement in both experimental and translational studies. Notable recent papers include:

  • Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein, 2020, Journal of Alzheimer s Disease
  • Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model, 2021, Scientific Reports
  • Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain, 2021, Human Molecular Genetics
  • γ-Secretase Activity Is Associated with Braak Senile Plaque Stages, 2020, American Journal Of Pathology
  • Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice, 2020, Journal of Biological Chemistry

The most frequent publication venues for Suzuki's work include:

  • Journal of Alzheimer s Disease
  • Scientific Reports
  • Alzheimer s & Dementia
  • Human Molecular Genetics
  • American Journal Of Pathology

Collaborations have been an essential part of Suzuki's research activities. Frequent co-authors associated with their work are:

  • Saori Hata
  • Takaomi C. Saido
  • Yuriko Sobu
  • Takashi Saito
  • Hidenori Taru

Their work is positioned mainly within these fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

In terms of subfields, Suzuki's research addresses:

  • Physiology
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Genetics

Best Publications

  • The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

    Ruth C. von Rotz;Bernhard M. Kohli;Jérôme Bosset;Michelle Meier

  • Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice.

    Takeshi Itoh;Toshio Ikeda;Hiroshi Gomi;Shinobu Nakao

  • HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

    T Suzuki;S Kitao;H Matsushime;M Yoshida

  • Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

    Kanae Ando;Ko-ichi Iijima;Ko-ichi Iijima;James I. Elliott;Yutaka Kirino

  • Cap-specific terminalN6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

    S. Akichika;S. Hirano;Y. Shichino;T. Suzuki

  • Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

    T. Suzuki;M. Oishi;D.R. Marshak;A.J. Czernik

  • Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5

    Ko-ichi Iijima;Kanae Ando;Shizu Takeda;Yasushi Satoh

  • Cleavage of Alzheimer’s Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM

    Susumu Tomita;Yutaka Kirino;Toshiharu Suzuki

  • Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

    Tatsuya Hoshino;Naoya Murao;Takushi Namba;Masaya Takehara

  • Escherichia coli phage‐shock protein A (PspA) binds to membrane phospholipids and repairs proton leakage of the damaged membranes

    Ryuji Kobayashi;Toshiharu Suzuki;Masasuke Yoshida

  • Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene.

    Lian Li;Toshiharu Suzuki;Nozomu Mori;Paul Greengard

  • Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a.

    C Sasakawa;K Komatsu;T Tobe;T Suzuki

  • Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer’s Amyloid Precursor Protein

    Susumu Tomita;Toshinori Ozaki;Hidenori Taru;Shinobu Oguchi

  • vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA-guanine transglycosylase (Tgt) of Escherichia coli K-12.

    J M Durand;N Okada;T Tobe;M Watarai

  • A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

    Hidehiko Inomata;Yoshitaka Nakamura;Akira Hayakawa;Hiroyuki Takata

  • The absence of a surface protease, OmpT, determines the intercellular spreading ability of Shigella: the relationship between the ompT and kcpA loci

    N. Nakata;T. Tobe;I. Fukuda;T. Suzuki

  • F0F1-ATPase/Synthase Is Geared to the Synthesis Mode by Conformational Rearrangement of ϵ Subunit in Response to Proton Motive Force and ADP/ATP Balance

    Toshiharu Suzuki;Tomoe Murakami;Ryota Iino;Junko Suzuki

  • Interaction of Alzheimer's β-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signaling Cascade *

    Hidenori Taru;Ko-ichi Iijima;Ko-ichi Iijima;Momoko Hase;Yutaka Kirino

  • ATP-driven stepwise rotation of FoF1-ATP synthase

    Hiroshi Ueno;Toshiharu Suzuki;Kazuhiko Kinosita;Masasuke Yoshida

  • Novel Cadherin-related Membrane Proteins, Alcadeins, Enhance the X11-like Protein-mediated Stabilization of Amyloid β-Protein Precursor Metabolism

    Yoichi Araki;Susumu Tomita;Haruyasu Yamaguchi;Naomi Miyagi

Frequent Co-Authors

Masasuke Yoshida
Masasuke Yoshida Kyoto Sangyo University
Masahiro Maeda
Masahiro Maeda Osaka University
Sam Gandy
Sam Gandy Icahn School of Medicine at Mount Sinai
Angus C. Nairn
Angus C. Nairn Yale University
Hiroyuki Noji
Hiroyuki Noji University of Tokyo
Kazuo Yamamoto
Kazuo Yamamoto University of Tokyo
Paul Greengard
Paul Greengard Rockefeller University
Ralph N. Martins
Ralph N. Martins Edith Cowan University
Masataka Kinjo
Masataka Kinjo Hokkaido University
Shigeyoshi Itohara
Shigeyoshi Itohara RIKEN Center for Brain Science

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