World's Best Scientists 2026 revealed!
Philippe J. Sansonetti

Philippe J. Sansonetti

Award Badge
Microbiology
France
2026

D-Index & Metrics

Microbiology

D-Index
152
Citations
76284
World Ranking
31
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Microbiology in France Leader Award
  • 2025 - Research.com Microbiology in France Leader Award
  • 2023 - Research.com Microbiology in France Leader Award
  • 2022 - Research.com Microbiology in France Leader Award
  • 2014 - Fellow of the Royal Society, United Kingdom
  • 2012 - Member of the National Academy of Sciences
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2002 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Microbiology and Immunology
  • 2001 - Member of Academia Europaea
  • 1997 - Robert Koch Prize
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Philippe J. Sansonetti is affiliated with the Institut Pasteur in France and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields including nutrition and dietetics, infectious diseases, molecular biology, endocrinology, and genetics.

Their work addresses key topics such as child nutrition and water access, gut microbiota and health, research on Clostridium difficile and Clostridium perfringens, infant nutrition and health, viral gastroenteritis research and epidemiology, Escherichia coli studies, and oral microbiology and periodontitis research.

Frequent coauthors collaborating with Sansonetti include Pascale Vonaesch, Maheninasy Rakotondrainipiana, Jean-Marc Collard, Rindra Vatosoa Randremanana, and Nathalie Kapel.

Scientific publications by Sansonetti appear in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Gut Microbes, Nature Microbiology, and EMBO Molecular Medicine.

Among recent research papers authored or coauthored by Sansonetti are:

  • Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study (2020, The Lancet Infectious Diseases)
  • Innate immune receptor NOD2 mediates LGR5 + intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation (2020, Proceedings of the National Academy of Sciences)
  • Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes (2023, Gut Microbes)
  • Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential "Driver" Role for Enterotoxigenic Bacteroides fragilis (2022, Frontiers in Cellular and Infection Microbiology)
  • Stunted children display ectopic small intestinal colonization by oral bacteria, which cause lipid malabsorption in experimental models (2022, Proceedings of the National Academy of Sciences)

Sansonetti has also contributed to book publications, including "Tu aimeras tes microbes comme toi-même" published by Collège de France eBooks in 2020.

Their scientific contributions have been recognized with various awards and honors, including being named a Fellow of the Royal Society (United Kingdom, 2014), Member of the National Academy of Sciences (2012), Fellow of the American Association for the Advancement of Science (AAAS, 2006), Member of the German National Academy of Sciences Leopoldina in Microbiology and Immunology (2002), Member of Academia Europaea (2001), recipient of the Robert Koch Prize (1997), and membership of the European Molecular Biology Organization (EMBO).

Best Publications

  • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

    Stephen E. Girardin;Ivo G. Boneca;Jérôme Viala;Mathias Chamaillard

  • Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

    Stephen E Girardin;Ivo G Boneca;Leticia A M Carneiro;Aude Antignac

  • Global Burden of Shigella Infections: Implications for Vaccine Development and Implementation of Control Strategies

    K. L. Kotloff;J. P. Winickoff;B. Ivanoff;J. D. Clemens

  • Shigella flexneri induces apoptosis in infected macrophages

    Arturo Zychlinsky;Marie Christine Prevost;Philippe J. Sansonetti

  • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

    Jerome Viala;Catherine Chaput;Ivo G Boneca;Ana Cardona

  • Bacterial invasion: the paradigms of enteroinvasive pathogens.

    Pascale Cossart;Philippe J. Sansonetti

  • Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells.

    R Ménard;P J Sansonetti;C Parsot

  • Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

    Maria L. Bernardini;Joelle Mounier;Helend D'Hauteville;Miguel Coquis-Rondon

  • Involvement of a plasmid in the invasive ability of Shigella flexneri.

    P J Sansonetti;D J Kopecko;S B Formal

  • War and peace at mucosal surfaces

    Philippe J Sansonetti

  • Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

    Jacques Amar;Chantal Chabo;Aurelie Waget;Pascale Klopp

  • In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2.

    J L Gaillard;P Berche;J Mounier;S Richard

  • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

    Stephen E. Girardin;Leonardo H. Travassos;Mireille Hervé;Didier Blanot

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis.

    P J Sansonetti;A Ryter;P Clerc;A T Maurelli

  • The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.

    Ariel Blocker;Pierre Gounon;Eric Larquet;Kirsten Niebuhr

  • Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

    Coumaran Egile;Thomas P. Loisel;Valérie Laurent;Rong Li

  • Secretory component : a new role in secretory IgA-mediated immune exclusion in vivo

    Armelle Phalipon;Ana Cardona;Jean Pierre Kraehenbuhl;Léna Edelman

  • Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes.

    J L Gaillard;P Berche;P Sansonetti

  • Life on the inside: the intracellular lifestyle of cytosolic bacteria.

    Katrina Ray;Benoit Marteyn;Benoit Marteyn;Philippe J. Sansonetti;Christoph M. Tang

  • Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation

    Philippe J Sansonetti;Armelle Phalipon;Josette Arondel;Kavitha Thirumalai

Frequent Co-Authors

Claude Parsot
Claude Parsot Institut Pasteur
Dana J. Philpott
Dana J. Philpott University of Toronto
Stephen E. Girardin
Stephen E. Girardin University of Toronto
Pierre Gounon
Pierre Gounon Université Côte d'Azur
Nancy Guillén
Nancy Guillén Institut Pasteur
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur
Bertrand Dupont
Bertrand Dupont Necker-Enfants Malades Hospital
Jean-Marc Cavaillon
Jean-Marc Cavaillon Institut Pasteur
Sylvain Brisse
Sylvain Brisse Institut Pasteur

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying microbiology in the USA opens doors to various online degrees and career options in healthcare and science. For those seeking flexible education paths, exploring the best degrees for felons can be encouraging, as certain microbiology-related programs offer second chances with promising future prospects.

One intriguing pathway is becoming a functional medicine nurse practitioner. This role combines healthcare and holistic science, making it an exciting option for microbiology graduates interested in patient-centered care. Learn more about how to become a functional medicine np and leverage your science background into clinical practice.

Alternatively, careers such as certified professional coders offer stability and growth. These professionals play a crucial role in healthcare administration, and understanding their earning potential and career paths can be helpful when considering related fields. Check out details on cpc salary to weigh your options.

Additionally, health information managers are vital in managing patient data and healthcare systems. The demand for such roles is growing, and salaries can be lucrative. Investigate typical roles and pay by visiting the health information manager salary page.

Best Scientists Citing Philippe J. Sansonetti

Trending Scientists

Recently Published Articles