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Dana J. Philpott

Dana J. Philpott

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Immunology
Canada
2026

D-Index & Metrics

Immunology

D-Index
100
Citations
41625
World Ranking
721
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Immunology in Canada Leader Award
  • 2025 - Research.com Immunology in Canada Leader Award

Overview

Dana J. Philpott is affiliated with the University of Toronto in Canada and has made contributions primarily in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Their research strongly focuses on Immunology, Molecular Biology, Genetics, Epidemiology, and Surgery as key subfields.

Their work addresses several main topics including:

  • Gut microbiota and health
  • Immune Cell Function and Interaction
  • Autophagy in Disease and Therapy
  • IL-33, ST2, and ILC Pathways
  • Inflammasome and immune disorders
  • Inflammatory Bowel Disease
  • Immune cells in cancer

Notable recent publications by Dana J. Philpott include:

  • "Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity," 2022, Immunity
  • "How autophagy controls the intestinal epithelial barrier," 2021, Autophagy
  • "Mitophagy pathways in health and disease," 2020, The Journal of Cell Biology
  • "The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease," 2024, Science Signaling
  • "Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells," 2021, Cell Reports

Dana J. Philpott frequently publishes in several scientific journals, including:

  • Journal of the Canadian Association of Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Immunity
  • Nature Communications

Collaboration has been an aspect of their scientific activity, with numerous coauthors including:

  • Stephen E. Girardin
  • Elisabeth G. Foerster
  • Nathaniel J. Winsor
  • Tapas Mukherjee
  • Giuliano Bayer

Best Publications

  • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

    Stephen E. Girardin;Ivo G. Boneca;Jérôme Viala;Mathias Chamaillard

  • Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

    Stephen E Girardin;Ivo G Boneca;Leticia A M Carneiro;Aude Antignac

  • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

    Leonardo H Travassos;Leticia A M Carneiro;Mahendrasingh Ramjeet;Seamus Hussey;Seamus Hussey

  • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

    Jerome Viala;Catherine Chaput;Ivo G Boneca;Ana Cardona

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Nod-like proteins in immunity, inflammation and disease.

    Jorg H Fritz;Richard Louis Ferrero;D J Philpott;Stephen E Girardin

  • Bacterial infection causes stress-induced memory dysfunction in mice

    Mélanie G Gareau;Eytan Wine;Eytan Wine;David M Rodrigues;Joon Ho Cho

  • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

    Stephen E. Girardin;Leonardo H. Travassos;Mireille Hervé;Didier Blanot

  • Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

    Unknown

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • NOD proteins: regulators of inflammation in health and disease

    Dana J. Philpott;Matthew T. Sorbara;Susan J. Robertson;Kenneth Croitoru

  • Recognition of Staphylococcus aureus by the Innate Immune System

    Bénédicte Fournier;Dana J. Philpott

  • Modulating immunity as a therapy for bacterial infections.

    Robert E. W. Hancock;Anastasia Nijnik;Dana J. Philpott

  • Toll‐like receptor 2‐dependent bacterial sensing does not occur via peptidoglycan recognition

    Leonardo H Travassos;Leonardo H Travassos;Stephen E Girardin;Dana J Philpott;Didier Blanot

  • Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

    Maria Kaparakis;Lynne Turnbull;Leticia Carneiro;Stephen Firth

  • Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

    Antoaneta Belcheva;Thergiory Irrazabal;Susan J. Robertson;Catherine Streutker

  • Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

    Jörg H. Fritz;Stephen E. Girardin;Catherine Fitting;Catherine Werts

  • Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.

    Mathias Chamaillard;Stephen E. Girardin;Jérôme Viala;Dana J. Philpott

  • NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

    Ivan Tattoli;Leticia A Carneiro;Muguette Jéhanno;Joao G Magalhaes

  • A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

    Ivo G. Boneca;Olivier Dussurget;Didier Cabanes;Marie-Anne Nahori

  • Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

    Kirsten Niebuhr;Sylvie Giuriato;Thierry Pedron;Dana J. Philpott

Frequent Co-Authors

Stephen E. Girardin
Stephen E. Girardin University of Toronto
Richard L. Ferrero
Richard L. Ferrero Hudson Institute of Medical Research
Philippe J. Sansonetti
Philippe J. Sansonetti Institut Pasteur
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur
Damien Arnoult
Damien Arnoult Grenoble Alpes University
Philip M. Sherman
Philip M. Sherman University of Toronto
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Michael Glogauer
Michael Glogauer University of Toronto
Anne M. Griffiths
Anne M. Griffiths University of Toronto
Amira Klip
Amira Klip University of Toronto

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