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Stephen E. Girardin

Stephen E. Girardin

D-Index & Metrics

Immunology

D-Index
96
Citations
58721
World Ranking
839
National Ranking
14

Overview

Stephen E. Girardin is affiliated with the University of Toronto in Canada. Their research spans multiple fields within biomedical science, with a focus on immunology, molecular biology, and medicine. Girardin's work covers diverse subfields such as immunology, molecular biology, epidemiology, genetics, and oncology.

The scientist's main research topics include autophagy in disease and therapy, inflammasome and immune disorders, gut microbiota and health, mitochondrial function and pathology, immune cell function and interaction, immune cells in cancer, and endoplasmic reticulum stress and disease.

Frequent publication venues where Stephen E. Girardin has contributed include bioRxiv (Cold Spring Harbor Laboratory), the Journal of the Canadian Association of Gastroenterology, Communications Biology, The Journal of Immunology, and Autophagy.

Collaborative work features several recurrent coauthors, prominently Dana J. Philpott, Elisabeth G. Foerster, Derek K.L. Tsang, Catherine Streutker, and Tapas Mukherjee.

Recent papers represent a range of topics with impactful contributions:

  • "How autophagy controls the intestinal epithelial barrier" (2021, Autophagy)
  • "Mitophagy pathways in health and disease" (2020, The Journal of Cell Biology)
  • "The conceptual foundations of innate immunity: Taking stock 30 years later" (2024, Immunity)
  • "Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells" (2021, Cell Reports)
  • "Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1" (2022, Molecular Cell)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

    Stephen E. Girardin;Ivo G. Boneca;Jérôme Viala;Mathias Chamaillard

  • Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

    Stephen E Girardin;Ivo G Boneca;Leticia A M Carneiro;Aude Antignac

  • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

    Leonardo H Travassos;Leticia A M Carneiro;Mahendrasingh Ramjeet;Seamus Hussey;Seamus Hussey

  • Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation

    L Ferrero-Miliani;O H Nielsen;P S Andersen;S E Girardin

  • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

    Jerome Viala;Catherine Chaput;Ivo G Boneca;Ana Cardona

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Nod-like proteins in immunity, inflammation and disease.

    Jorg H Fritz;Richard Louis Ferrero;D J Philpott;Stephen E Girardin

  • WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

    Hannah C. Dooley;Minoo Razi;Hannah E.J. Polson;Stephen E. Girardin

  • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

    Stephen E. Girardin;Leonardo H. Travassos;Mireille Hervé;Didier Blanot

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • NOD proteins: regulators of inflammation in health and disease

    Dana J. Philpott;Matthew T. Sorbara;Susan J. Robertson;Kenneth Croitoru

  • Toll‐like receptor 2‐dependent bacterial sensing does not occur via peptidoglycan recognition

    Leonardo H Travassos;Leonardo H Travassos;Stephen E Girardin;Dana J Philpott;Didier Blanot

  • Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

    Laure Gurcel;Laurence Abrami;Stephen Girardin;Jurg Tschopp

  • Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

    Maria Kaparakis;Lynne Turnbull;Leticia Carneiro;Stephen Firth

  • Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

    Antoaneta Belcheva;Thergiory Irrazabal;Susan J. Robertson;Catherine Streutker

  • Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

    Jörg H. Fritz;Stephen E. Girardin;Catherine Fitting;Catherine Werts

  • NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.

    Gerben Ferwerda;Stephen E. Girardin;Bart Jan Kullberg;Lionel Le Bourhis

  • Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.

    Mathias Chamaillard;Stephen E. Girardin;Jérôme Viala;Dana J. Philpott

  • NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

    Ivan Tattoli;Leticia A Carneiro;Muguette Jéhanno;Joao G Magalhaes

  • A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

    Ivo G. Boneca;Olivier Dussurget;Didier Cabanes;Marie-Anne Nahori

  • Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

    Jorg H Fritz;Lionel Le Bourhis;Gernot Sellge;Joao Gamelas Magalhaes

Frequent Co-Authors

Dana J. Philpott
Dana J. Philpott University of Toronto
Philippe J. Sansonetti
Philippe J. Sansonetti Institut Pasteur
Mihai G. Netea
Mihai G. Netea Radboud University
Damien Arnoult
Damien Arnoult Grenoble Alpes University
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur
Richard L. Ferrero
Richard L. Ferrero Hudson Institute of Medical Research
Sandrine Florquin
Sandrine Florquin University of Amsterdam
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Jos W. M. van der Meer
Jos W. M. van der Meer Radboud University Medical Center
Leo A. B. Joosten
Leo A. B. Joosten Radboud University

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