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Biology and Biochemistry

D-Index
95
Citations
53034
World Ranking
1862
National Ranking
1023

Overview

Naohiro Inohara is affiliated with the University of Michigan-Ann Arbor in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with notable work in medicine. The scientist's expertise extends into several subfields, including molecular biology, immunology, genetics, infectious diseases, and food science.

Inohara's main topics of research cover a range of biomedical and microbiological areas. These include gut microbiota and health, inflammatory bowel disease, probiotics and fermented foods, as well as studies on Clostridium difficile and Clostridium perfringens. Additional research interests lie in tryptophan and brain disorders, inflammasome and immune disorders, and oral microbiology and periodontitis.

Their publication record features several recent papers that contribute to the understanding of host-microbe interactions and immune responses. Notable publications include:

  • The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis, 2020, Cell
  • Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer, 2021, Nature Communications
  • An Enteric Pathogen Subverts Colonization Resistance by Evading Competition for Amino Acids in the Gut, 2020, Cell Host & Microbe
  • Gut bacteria-derived serotonin promotes immune tolerance in early life, 2024, Science Immunology
  • Microbiota-dependent activation of CD4 + T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors, 2024, Science

Inohara frequently collaborates with other researchers. Regular co-authors include:

  • Gabriel Núñez
  • Nobuhiko Kamada
  • Katherine Z. Sanidad
  • Roberta Caruso
  • Peter Kuffa

The scientist has published in several key academic venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature Communications
  • Cell Host & Microbe
  • Science Immunology

Best Publications

  • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

    Yasunori Ogura;Denise K. Bonen;Naohiro Inohara;Dan L. Nicolae

  • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.

    Koichi S. Kobayashi;Mathias Chamaillard;Yasunori Ogura;Octavian Henegariu

  • Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE

    Naohiro Inohara;Yasunori Ogura;Ana Fontalba;Olga Gutierrez

  • Control of pathogens and pathobionts by the gut microbiota.

    Nobuhiko Kamada;Grace Y Chen;Naohiro Inohara;Gabriel Núñez

  • Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB *

    Yasunori Ogura;Naohiro Inohara;Adalberto Benito;Felicia F. Chen

  • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

    Mathias Chamaillard;Masahito Hashimoto;Yasuo Horie;Junya Masumoto

  • Caspases: the proteases of the apoptotic pathway

    Gabriel Nuñez;Mary A. Benedict;Yuanmimg Hu;Naohiro Inohara

  • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

    Luigi Franchi;Amal Amer;Mathilde Body-Malapel;Thirumala Devi Kanneganti

  • NODs: intracellular proteins involved in inflammation and apoptosis.

    Naohiro Inohara;Gabriel Nuñez

  • NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

    Naohiro Inohara;Mathias Chamaillard;Christine McDonald;Gabriel Nuñez

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

    Koichi Kobayashi;Naohiro Inohara;Lorraine D. Hernandez;Jorge E. Galán

  • Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

    Naohiro Inohara;Takeyoshi Koseki;Luis del Peso;Yuanming Hu

  • Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

    Thirumala Devi Kanneganti;Mathilde Body-Malapel;Amal Amer;Jong Hwan Park

  • Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

    Yuanming Hu;Mary A. Benedict;Dayang Wu;Naohiro Inohara

  • Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

    Naohiro Inohara;Yasunori Ogura;Felicia F. Chen;Akihiro Muto

  • NOD1 and NOD2: signaling, host defense, and inflammatory disease.

    Roberta Caruso;Neil Warner;Naohiro Inohara;Gabriel Núñez

  • Mechanisms of inflammation-driven bacterial dysbiosis in the gut.

    M Y Zeng;N Inohara;G Nuñez

  • Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

    Toshihiko Suzuki;Luigi Franchi;Claudia Toma;Hiroshi Ashida

  • An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

    Naohiro Inohara;Takeyoshi Koseki;Jingmei Lin;Luis Del Peso

Frequent Co-Authors

Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor
Koichi Fukase
Koichi Fukase Osaka University
Nobuhiko Kamada
Nobuhiko Kamada University of Michigan–Ann Arbor
Mathias Chamaillard
Mathias Chamaillard University of Lille
Shigeo Ohta
Shigeo Ohta Juntendo University
Shinji Fukuda
Shinji Fukuda Kanagawa Institute of Technology
Luigi Franchi
Luigi Franchi University of Michigan–Ann Arbor
Hiroyasu Nakano
Hiroyasu Nakano Toho University
Simon J. Foster
Simon J. Foster University of Sheffield
Thirumala-Devi Kanneganti
Thirumala-Devi Kanneganti St. Jude Children's Research Hospital

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