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Luigi Franchi

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
27397
World Ranking
12251
National Ranking
5237

Luigi Franchi publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Luigi Franchi sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 99 publications — 5th percentile

5% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Luigi Franchi D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Luigi Franchi sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 59 D-Index — 38th percentile

38% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Luigi Franchi is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans multiple areas within medicine and the biological sciences, with a substantial focus on molecular and genetic aspects of immunology and disease mechanisms.

The primary fields of study associated with Luigi Franchi include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these domains, the scientist's work extends into several subfields, notably:

  • Genetics
  • Immunology
  • Molecular Biology
  • Epidemiology
  • Cancer Research

Key topics commonly addressed in their research involve:

  • Inflammasome and immune disorders
  • Virus-based gene therapy research
  • Eosinophilic Esophagitis
  • Glioma Diagnosis and Treatment
  • Cancer, Hypoxia, and Metabolism
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses

Luigi Franchi has contributed to a range of scientific publications across several reputable journals. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Immunology
  • Frontiers in Molecular Biosciences
  • Journal of Crohn's and Colitis

Selected recent publications demonstrate the scope of Luigi Franchi's work:

  • OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment, 2022, Science Immunology
  • The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis, 2021, Frontiers in Molecular Biosciences
  • Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor, 2025, Journal of Medicinal Chemistry
  • NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases, 2023, Journal of Crohn's and Colitis
  • Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma, 2024, Nature Communications

Collaborations are a notable aspect of Luigi Franchi's research efforts. Frequent co-authors include:

  • Anthony W. Opipari
  • Nneka E. Mbah
  • Hanna S. Hong
  • Mengrou Shan
  • Peter Sajjakulnukit

Best Publications

  • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

    Peter Duewell;Hajime Kono;Katey J. Rayner;Katey J. Rayner;Cherilyn M. Sirois

  • The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

    Luigi Franchi;Tatjana Eigenbrod;Raúl Muñoz-Planillo;Gabriel Nuñez

  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

    Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

  • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

    Luigi Franchi;Amal Amer;Mathilde Body-Malapel;Thirumala Devi Kanneganti

  • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

    Thirumala Devi Kanneganti;Nesrin Özören;Mathilde Body-Malapel;Amal Amer

  • Sensing and reacting to microbes through the inflammasomes

    Luigi Franchi;Raul Muñoz-Planillo;Gabriel Núñez

  • Function of Nod-like receptors in microbial recognition and host defense.

    Luigi Franchi;Neil Warner;Kyle Viani;Gabriel Nuñez

  • Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

    Thirumala Devi Kanneganti;Mathilde Body-Malapel;Amal Amer;Jong Hwan Park

  • Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

    Toshihiko Suzuki;Luigi Franchi;Claudia Toma;Hiroshi Ashida

  • Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

    Luigi Franchi;Tatjana Eigenbrod;Gabriel Núñez

  • Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

    Franz Bauernfeind;Eva Bartok;Anna Rieger;Luigi Franchi

  • Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

    Yan Qu;Luigi Franchi;Gabriel Nunez;George R. Dubyak

  • Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.

    Thirumala Devi Kanneganti;Mohamed Lamkanfi;Yun Gi Kim;Grace Chen

  • The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity

    Luigi Franchi;Gabriel Núñez

  • Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

    Amal Amer;Luigi Franchi;Thirumala Devi Kanneganti;Mathilde Body-Malapel

  • NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.

    Luigi Franchi;Nobuhiko Kamada;Yuumi Nakamura;Aaron Burberry

  • Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.

    Luigi Franchi;Thirumala Devi Kanneganti;George R. Dubyak;Gabriel Núñez

  • A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.

    Raúl Muñoz-Planillo;Luigi Franchi;Lloyd S. Miller;Gabriel Núñez

  • The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.

    Yun Gi Kim;Jong Hwan Park;Michael H. Shaw;Luigi Franchi

  • Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))

    Peter Duewell;Hajime Kono;Katey J. Rayner;Cherilyn M. Sirois

Frequent Co-Authors

Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor
Thirumala-Devi Kanneganti
Thirumala-Devi Kanneganti St. Jude Children's Research Hospital
Shizuo Akira
Shizuo Akira Osaka University
George R. Dubyak
George R. Dubyak Case Western Reserve University
Naohiro Inohara
Naohiro Inohara University of Michigan–Ann Arbor
Peter Vandenabeele
Peter Vandenabeele Ghent University
Kathryn J. Moore
Kathryn J. Moore New York University Langone Medical Center
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Veit Hornung
Veit Hornung Ludwig-Maximilians-Universität München
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School

External Links

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Best Scientists Citing Luigi Franchi

Eicke Latz

Eicke Latz

German Rheumatism Research Centre

Publications: 159

Thirumala-Devi Kanneganti

Thirumala-Devi Kanneganti

St. Jude Children's Research Hospital

Publications: 140

Gabriel Núñez

Gabriel Núñez

University of Michigan–Ann Arbor

Publications: 79

Richard A. Flavell

Richard A. Flavell

Yale University

Publications: 78

Katherine A. Fitzgerald

Katherine A. Fitzgerald

University of Massachusetts Chan Medical School

Publications: 71

Shizuo Akira

Shizuo Akira

Osaka University

Publications: 64

Charles A. Dinarello

Charles A. Dinarello

University of Colorado Anschutz Medical Campus

Publications: 59

Mohamed Lamkanfi

Mohamed Lamkanfi

Ghent University

Publications: 57

Dario S. Zamboni

Dario S. Zamboni

Universidade de São Paulo

Publications: 52

Jenny P.-Y. Ting

Jenny P.-Y. Ting

University of North Carolina at Chapel Hill

Publications: 51

Dana J. Philpott

Dana J. Philpott

University of Toronto

Publications: 48

Mihai G. Netea

Mihai G. Netea

Radboud University

Publications: 47

Jürg Tschopp

Jürg Tschopp

University of Lausanne

Publications: 45

Stephen E. Girardin

Stephen E. Girardin

University of Toronto

Publications: 44

Fayyaz S. Sutterwala

Fayyaz S. Sutterwala

Cedars-Sinai Medical Center

Publications: 44

Leo A. B. Joosten

Leo A. B. Joosten

Radboud University

Publications: 43

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