Luigi Franchi

Overview

Best Publications

• NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

  Peter Duewell;Hajime Kono;Katey J. Rayner;Katey J. Rayner;Cherilyn M. Sirois

  4380
  Citations

• The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

  Luigi Franchi;Tatjana Eigenbrod;Raúl Muñoz-Planillo;Gabriel Nuñez

  2127
  Citations

• Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

  Seth L Masters;Aisling Dunne;Shoba L Subramanian;Rebecca L Hull

  1468
  Citations

• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

  Luigi Franchi;Amal Amer;Mathilde Body-Malapel;Thirumala Devi Kanneganti

  1389
  Citations

• Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

  Thirumala Devi Kanneganti;Nesrin Özören;Mathilde Body-Malapel;Amal Amer

  1341
  Citations

• Sensing and reacting to microbes through the inflammasomes

  Luigi Franchi;Raul Muñoz-Planillo;Gabriel Núñez

  1317
  Citations

• Function of Nod-like receptors in microbial recognition and host defense.

  Luigi Franchi;Neil Warner;Kyle Viani;Gabriel Nuñez

  1018
  Citations

• Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

  Thirumala Devi Kanneganti;Mathilde Body-Malapel;Amal Amer;Jong Hwan Park

  834
  Citations

• Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

  Toshihiko Suzuki;Luigi Franchi;Claudia Toma;Hiroshi Ashida

  748
  Citations

• Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

  Luigi Franchi;Tatjana Eigenbrod;Gabriel Núñez

  719
  Citations

• Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

  Franz Bauernfeind;Eva Bartok;Anna Rieger;Luigi Franchi

  708
  Citations

• Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

  Yan Qu;Luigi Franchi;Gabriel Nunez;George R. Dubyak

  678
  Citations

• Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.

  Thirumala Devi Kanneganti;Mohamed Lamkanfi;Yun Gi Kim;Grace Chen

  646
  Citations

• The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity

  Luigi Franchi;Gabriel Núñez

  607
  Citations

• Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

  Amal Amer;Luigi Franchi;Thirumala Devi Kanneganti;Mathilde Body-Malapel

  559
  Citations

• NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.

  Luigi Franchi;Nobuhiko Kamada;Yuumi Nakamura;Aaron Burberry

  508
  Citations

• Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria.

  Luigi Franchi;Thirumala Devi Kanneganti;George R. Dubyak;Gabriel Núñez

  412
  Citations

• A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.

  Raúl Muñoz-Planillo;Luigi Franchi;Lloyd S. Miller;Gabriel Núñez

  393
  Citations

• The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.

  Yun Gi Kim;Jong Hwan Park;Michael H. Shaw;Luigi Franchi

  383
  Citations

• Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))

  Peter Duewell;Hajime Kono;Katey J. Rayner;Cherilyn M. Sirois

  24
  Citations