World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
108
Citations
36718
World Ranking
1064
National Ranking
642

Overview

Xianglin Shi is affiliated with the University of Kentucky in the United States and has a research focus primarily in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Rheumatology, Pharmacology, Cancer Research, and Oncology.

The scientist's research covers a range of topics with notable emphasis on osteoarthritis treatment and mechanisms, breast cancer treatment studies, and the pharmacological effects of natural compounds. Other main topics include inflammatory mediators and NSAID effects, gout, hyperuricemia, uric acid, HER2/EGFR in cancer research, and breast lesions and carcinomas.

They have published extensively in various scientific venues, with frequent publications in:

  • Frontiers in Pharmacology
  • International Immunopharmacology
  • Research Square (Research Square)
  • Journal of Ethnopharmacology
  • Nanomedicine

Selected recent papers demonstrate the focus of their research:

  • Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling, 2020, International Immunopharmacology
  • Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways, 2022, Journal of Ethnopharmacology
  • Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Radix Achyranthis Bidentatae on Osteoarthritis, 2020, BMC Complementary Medicine and Therapies
  • Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis, 2020, BioMed Research International
  • Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis, 2021, Frontiers in Pharmacology

Xianglin Shi collaborates regularly with a core group of frequent coauthors, including Li Zhang, Lishi Jie, Xiaochen Li, Songjiang Yin, and Jun J. Mao. The collaborations suggest a network of researchers working in related biomedical fields, particularly focused on pharmacology and disease mechanisms.

Best Publications

  • New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

    Fei Chen;Vince Castranova;Xianglin Shi;Laurence M. Demers

  • Oxidative mechanism of arsenic toxicity and carcinogenesis.

    Honglian Shi;Xianglin Shi;Ke Jian Liu

  • Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.

    Stephen S Leonard;Chang Xia;Bin-Hua Jiang;Beth Stinefelt

  • Metal-induced oxidative stress and signal transduction.

    Stephen S. Leonard;Gabriel K. Harris;Xianglin Shi

  • New Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation

    Fei Chen;Vince Castranova;Xianglin Shi

  • Diseases caused by silica: mechanisms of injury and disease development

    Min Ding;Fei Chen;Xianglin Shi;Berran Yucesoy

  • G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.

    Ning Gao;Daniel C. Flynn;Zhuo Zhang;Xiao-Song Zhong

  • Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

    Patrick L Apopa;Patrick L Apopa;Yong-Gang Qian;Rong Shao;Nancy Lan Guo

  • Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury.

    Val Vallyathan;Xianglin Shi;Nar S. Dalal;William Irr

  • Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity

    Min Ding;Rentian Feng;Shiow Y. Wang;Linda Bowman

  • REDUCTION OF CHROMIUM (VI) AND ITS RELATIONSHIP TO CARCINOGENESIS

    X Shi;A Chiu;C T Chen;B Halliwell

  • Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes.

    Sujatha Dokka;David Toledo;Xianglin Shi;Vincent Castranova

  • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer.

    Ning Gao;Zhuo Zhang;Bing-Hua Jiang;Bing-Hua Jiang;Xianglin Shi

  • Oxidative stress and metal carcinogenesis.

    Jeong-Chae Lee;Young-Ok Son;Poyil Pratheeshkumar;Xianglin Shi

  • Molecular mechanisms of arsenic carcinogenesis.

    Chuanshu Huang;Qingdong Ke;Max Costa;Xianglin Shi

  • Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis.

    Jianping Ye;Suwei Wang;Suwei Wang;Stephen S. Leonard;Stephen S. Leonard;Yi Sun

  • Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.

    Poyil Pratheeshkumar;Amit Budhraja;Young-Ok Son;Xin Wang

  • The role of oxygen free radicals in occupational and environmental lung diseases.

    Val Vallyathan;Xianglin Shi

  • Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression

    Jing Fang;Qiong Zhou;Ling-Zhi Liu;Chang Xia

  • Molecular mechanisms of metal toxicity and

    Suwei Wang;Xianglin Shi

Frequent Co-Authors

Zhuo Zhang
Zhuo Zhang University of Kentucky
Stephen S. Leonard
Stephen S. Leonard National Institute for Occupational Safety and Health
Fei Chen
Fei Chen Stony Brook University
Val Vallyathan
Val Vallyathan National Institute for Occupational Safety and Health
Young-Ok Son
Young-Ok Son Gwangju Institute of Science and Technology
Vincent Castranova
Vincent Castranova West Virginia University
Vince Castranova
Vince Castranova West Virginia University
Min Ding
Min Ding National Institute for Occupational Safety and Health
Chuanshu Huang
Chuanshu Huang New York University
Jeong-Chae Lee
Jeong-Chae Lee Jeonbuk National University

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