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Biology and Biochemistry

D-Index
58
Citations
17054
World Ranking
12963
National Ranking
440

Overview

Michael F. Olson is affiliated with Toronto Metropolitan University in Canada. Their research primarily lies within the broad field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Cell Biology, Immunology, Cardiology and Cardiovascular Medicine, and Cellular and Molecular Neuroscience.

The scientist's main topics of work include:

  • Cellular Mechanics and Interactions
  • Phagocytosis and Immune Regulation
  • Cardiomyopathy and Myosin Studies
  • Cell death mechanisms and regulation
  • Protein Kinase Regulation and GTPase Signaling
  • Axon Guidance and Neuronal Signaling
  • Angiogenesis and VEGF in Cancer

Michael F. Olson has contributed to numerous research articles. Recent notable papers include:

  • "Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1," published in 2020 in Small GTPases
  • "MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours," published in 2021 in Cancer Letters
  • "MICAL1 activation by PAK1 mediates actin filament disassembly," published in 2022 in Cell Reports
  • "Organotypic platform for studying cancer cell metastasis," published in 2021 in Experimental Cell Research
  • "Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging," published in 2021 in Cell Reports

Frequent collaborators include Margarita Byrsan, David J. McGarry, Karen Blyth, Linda Julian, and Gregory Naylor. Their collaborations span multiple papers, indicating ongoing research partnerships.

Michael F. Olson's work has been published extensively in several venues, such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Small GTPases
  • Cell Reports
  • Cancers

Best Publications

  • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

    Mathew L. Coleman;Erik A. Sahai;Margaret Yeo;Marta Bosch

  • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

    Michael F. Olson;Alan Ashworth;Alan Hall

  • The actin cytoskeleton in cancer cell motility.

    Michael F Olson;Erik A Sahai

  • Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

    Michael F. Olson;Hugh F. Paterson;Christopher J. Marshall

  • Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

    Michael S. Samuel;Jose I. Lopez;Ewan J. McGhee;Daniel R. Croft

  • Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

    Richard Marais;Yvonne Light;Clive Mason;Hugh Paterson

  • Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions

    Linda Julian;Michael F Olson

  • Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility.

    Erik Sahai;Michael F. Olson;C. J. Marshall

  • RAS and RHO GTPases in G1-phase cell-cycle regulation

    Mathew L. Coleman;Christopher J. Marshall;Michael F. Olson

  • Applications for ROCK kinase inhibition

    Michael F Olson

  • Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

    Thomas Jamieson;Mairi Clarke;Colin W. Steele;Michael S. Samuel

  • LIM kinases: function, regulation and association with human disease

    Rebecca W. Scott;Michael F. Olson

  • Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

    Nicola Rath;Michael F Olson

  • Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

    M L Coleman;M F Olson

  • Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

    Michael F. Olson;N.German Pasteris;Jerome L. Gorski;Alan Hall

  • How apoptotic cells aid in the removal of their own cold dead bodies

    G Wickman;L Julian;M F Olson

  • Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration

    Daniel R. Croft;Mathew L. Coleman;Shuixing Li;David Robertson

  • Mammary stem cells have myoepithelial cell properties

    Michael D. Prater;Valérie Petit;I. Alasdair Russell;Rajshekhar R. Giraddi

  • Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs.

    G R Wickman;L Julian;K Mardilovich;S Schumacher

  • Conditional ROCK Activation In vivo Induces Tumor Cell Dissemination and Angiogenesis

    Daniel R. Croft;Erik Sahai;Georgia Mavria;Shuixing Li

Frequent Co-Authors

Christopher J. Marshall
Christopher J. Marshall Institute of Cancer Research
Erik Sahai
Erik Sahai The Francis Crick Institute
Kurt I. Anderson
Kurt I. Anderson The Francis Crick Institute
Paul Timpson
Paul Timpson Garvan Institute of Medical Research
Samuel T Hwang
Samuel T Hwang University of California, Davis
Owen J. Sansom
Owen J. Sansom University of Glasgow
Alan Hall
Alan Hall Memorial Sloan Kettering Cancer Center
Marina Pajic
Marina Pajic Garvan Institute of Medical Research
Jonathan B. Baell
Jonathan B. Baell Monash University
Demin Wang
Demin Wang Medical College of Wisconsin

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