Jonathan B. Baell focuses on Biochemistry, Drug discovery, Pan-assay interference compounds, Pharmacology and Stereochemistry. His Biochemistry study combines topics in areas such as Sperm and Bioassay. His Drug discovery research incorporates themes from Combinatorial chemistry, Chemical biology, Histone acetyltransferase and Data science.
The Pan-assay interference compounds study combines topics in areas such as Natural product and Risk analysis. His research integrates issues of Apoptosis, Programmed cell death and In vitro, Structure–activity relationship in his study of Pharmacology. His In vitro study integrates concerns from other disciplines, such as Myeloid Cell Leukemia Sequence 1 Protein, Cancer, Cell culture, Cancer research and Bcl-xL.
His main research concerns Biochemistry, Stereochemistry, Pharmacology, Structure–activity relationship and Combinatorial chemistry. Jonathan B. Baell combines topics linked to Trypanosoma brucei rhodesiense with his work on Biochemistry. His studies in Stereochemistry integrate themes in fields like Benzoylurea, Peptidomimetic, Chemical synthesis and Small molecule.
He usually deals with Pharmacology and limits it to topics linked to In vitro and Cell culture and Plasmodium falciparum. His Structure–activity relationship study deals with Haemonchus contortus intersecting with Cytotoxicity. Jonathan B. Baell has researched Drug discovery in several fields, including Computational biology, High-throughput screening and Data science.
Jonathan B. Baell mainly investigates Drug discovery, Biochemistry, Catalysis, IC50 and Combinatorial chemistry. His Drug discovery study combines topics from a wide range of disciplines, such as Chemical biology, Haemonchus contortus, Structure–activity relationship and High-content screening. His Biochemistry research is multidisciplinary, incorporating elements of Interleukin and Function.
His IC50 research incorporates elements of Bcl-xL, Benzoylurea, Small molecule and Bh3 mimetics. The Combinatorial chemistry study combines topics in areas such as In situ, Selectivity, Cycloaddition and Copper catalyzed. His research investigates the link between Cytotoxicity and topics such as African trypanosomiasis that cross with problems in In vitro.
Catalysis, Interleukin, Enzyme, Function and Biochemistry are his primary areas of study. His work on Organic synthesis is typically connected to Functional group as part of general Catalysis study, connecting several disciplines of science. Interleukin is closely attributed to Glutathione transferase in his work.
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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan Bayldon Baell;Georgina A Holloway.
Journal of Medicinal Chemistry (2010)
Chemistry: Chemical con artists foil drug discovery
Jonathan Bayldon Baell;Michael A Walters.
Nature (2014)
The promise and peril of chemical probes.
Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell.
Nature Chemical Biology (2015)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.
Jonathan B. Baell;Jonathan B. Baell;J. Willem M. Nissink.
ACS Chemical Biology (2018)
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
Ron O. Dror;Hillary F. Green;Celine Valant;David W. Borhani.
Nature (2013)
Structure-guided design of a selective BCL-XL inhibitor
Guillaume Lessene;Guillaume Lessene;Peter Edward Czabotar;Peter Edward Czabotar;Brad Sleebs;Brad Sleebs;Kerry Zobel.
Nature Chemical Biology (2013)
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
Jonathan B. Baell.
Journal of Natural Products (2016)
FAF-Drugs3: a web server for compound property calculation and chemical library design
David Lagorce;Olivier Sperandio;Jonathan B. Baell;Maria A. Miteva.
Nucleic Acids Research (2015)
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.
Jonathan B. Baell;David C.S. Huang.
Biochemical Pharmacology (2002)
Assay Guidance Manual [Internet]
Sarine Markossian;Abigail Grossman;Kyle Brimacombe;Michelle Arkin.
(2004)
Future Medicinal Chemistry
(Impact Factor: 4.767)
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