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Wayne J. Fairbrother

Wayne J. Fairbrother

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
21664
World Ranking
7281
National Ranking
3339

Overview

Wayne J. Fairbrother is a researcher affiliated with Genentech in the United States. Their work primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology. Additional subfields include Immunology, Hematology, Atomic and Molecular Physics, and Optics, as well as Structural Biology.

The scientist's research covers various key topics, including:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Cell death mechanisms and regulation
  • Chemical Synthesis and Analysis
  • Signaling Pathways in Disease
  • Histone Deacetylase Inhibitors Research
  • RNA and protein synthesis mechanisms

Some of the most cited recent papers authored by or involving Wayne J. Fairbrother include:

  • Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor (2020), ACS Medicinal Chemistry Letters
  • Targeted degradation via direct 26S proteasome recruitment (2022), Nature Chemical Biology
  • Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and β-Hydroxy-γ4-amino Acids (2021), ACS Chemical Biology
  • Ribosomal Synthesis of Macrocyclic Peptides with β2- and β2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries (2021), ACS Chemical Biology
  • Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein (2021), Journal of the American Chemical Society

The frequent co-authors collaborating with Wayne J. Fairbrother include:

  • Ingrid E. Wertz
  • Robert A. Blake
  • Steven T. Staben
  • Melinda M. Mulvihill
  • Sumit Prakash

Wayne J. Fairbrother's work has appeared repeatedly in several scientific venues. The most common publication outlets are:

  • ACS Chemical Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Medicinal Chemistry Letters
  • Nature Chemical Biology
  • Nature Communications

Best Publications

  • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

    Andrew J Souers;Joel D Leverson;Erwin R Boghaert;Scott L Ackler

  • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

    Eugene Varfolomeev;John W. Blankenship;Sarah M. Wayson;Anna V. Fedorova

  • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

    Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  • From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

    Avi Ashkenazi;Wayne J. Fairbrother;Joel D. Leverson;Andrew J. Souers

  • c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

    Eugene Varfolomeev;Tatiana Goncharov;Anna V. Fedorova;Jasmin N. Dynek

  • Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

    Joel D. Leverson;Darren C. Phillips;Michael J. Mitten;Erwin R. Boghaert

  • Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

    J D Leverson;H Zhang;J Chen;S K Tahir

  • Structure-guided design of a selective BCL-XL inhibitor

    Guillaume Lessene;Guillaume Lessene;Peter Edward Czabotar;Peter Edward Czabotar;Brad Sleebs;Brad Sleebs;Kerry Zobel

  • Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

    Xiaoqing Sun;Jianping Yin;Melissa A. Starovasnik;Wayne J. Fairbrother

  • c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

    Jasmin N Dynek;Tatiana Goncharov;Erin C Dueber;Anna V Fedorova

  • SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

    Domagoj Vucic;Kurt Deshayes;Heidi Ackerly;Maria Teresa Pisabarro

  • ICEBERG: a novel inhibitor of interleukin-1beta generation.

    Eric W Humke;Eric W Humke;Stephanie K Shriver;Melissa A Starovasnik;Wayne J Fairbrother

  • Expression profile of BCL-2, BCL-XL and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models

    Elizabeth A. Punnoose;Joel D. Leverson;Franklin Peale;Erwin R. Boghaert

  • Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

    Zhi-Fu Tao;Lisa Hasvold;Le Wang;Xilu Wang

  • Structure of C3b in complex with CRIg gives insights into regulation of complement activation

    Christian Wiesmann;Kenneth J. Katschke;JianPing Yin;Karim Y. Helmy

  • Souers AJ, Leverson JD, Boghaert ER et al.ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 19:202-208

    Andrew J. Souers;Joel D. Leverson;Erwin R. Boghaert;Scott L. Ackler

  • Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

    Jane Gitschier;Barbara Moffat;Dorothea Reilly;William I. Wood

  • Exploring protein-protein interactions with phage display.

    Sachdev S. Sidhu;Wayne J. Fairbrother;Kurt Deshayes

  • Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).

    John A. Flygare;Maureen Beresini;Nageshwar Budha;Helen Chan

  • The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

    Domagoj Vucic;Wayne J. Fairbrother

Frequent Co-Authors

Domagoj Vucic
Domagoj Vucic Genentech
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Jonathan B. Baell
Jonathan B. Baell Monash University
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Frederick Cohen
Frederick Cohen Nurix Therapeutics
Christian Wiesmann
Christian Wiesmann Novartis (Switzerland)

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