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Wayne J. Fairbrother

Wayne J. Fairbrother

Genentech
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
21664
World Ranking
7281
National Ranking
3339

Wayne J. Fairbrother publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Wayne J. Fairbrother sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 205 publications — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Wayne J. Fairbrother D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Wayne J. Fairbrother sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 69 D-Index — 63rd percentile

63% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Wayne J. Fairbrother is a researcher affiliated with Genentech in the United States. Their work primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology. Additional subfields include Immunology, Hematology, Atomic and Molecular Physics, and Optics, as well as Structural Biology.

The scientist's research covers various key topics, including:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Cell death mechanisms and regulation
  • Chemical Synthesis and Analysis
  • Signaling Pathways in Disease
  • Histone Deacetylase Inhibitors Research
  • RNA and protein synthesis mechanisms

Some of the most cited recent papers authored by or involving Wayne J. Fairbrother include:

  • Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor (2020), ACS Medicinal Chemistry Letters
  • Targeted degradation via direct 26S proteasome recruitment (2022), Nature Chemical Biology
  • Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and β-Hydroxy-γ4-amino Acids (2021), ACS Chemical Biology
  • Ribosomal Synthesis of Macrocyclic Peptides with β2- and β2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries (2021), ACS Chemical Biology
  • Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein (2021), Journal of the American Chemical Society

The frequent co-authors collaborating with Wayne J. Fairbrother include:

  • Ingrid E. Wertz
  • Robert A. Blake
  • Steven T. Staben
  • Melinda M. Mulvihill
  • Sumit Prakash

Wayne J. Fairbrother's work has appeared repeatedly in several scientific venues. The most common publication outlets are:

  • ACS Chemical Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Medicinal Chemistry Letters
  • Nature Chemical Biology
  • Nature Communications

Best Publications

  • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

    Andrew J Souers;Joel D Leverson;Erwin R Boghaert;Scott L Ackler

  • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

    Eugene Varfolomeev;John W. Blankenship;Sarah M. Wayson;Anna V. Fedorova

  • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

    Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  • From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

    Avi Ashkenazi;Wayne J. Fairbrother;Joel D. Leverson;Andrew J. Souers

  • c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

    Eugene Varfolomeev;Tatiana Goncharov;Anna V. Fedorova;Jasmin N. Dynek

  • Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

    Joel D. Leverson;Darren C. Phillips;Michael J. Mitten;Erwin R. Boghaert

  • Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

    J D Leverson;H Zhang;J Chen;S K Tahir

  • Structure-guided design of a selective BCL-XL inhibitor

    Guillaume Lessene;Guillaume Lessene;Peter Edward Czabotar;Peter Edward Czabotar;Brad Sleebs;Brad Sleebs;Kerry Zobel

  • Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

    Xiaoqing Sun;Jianping Yin;Melissa A. Starovasnik;Wayne J. Fairbrother

  • c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

    Jasmin N Dynek;Tatiana Goncharov;Erin C Dueber;Anna V Fedorova

  • SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

    Domagoj Vucic;Kurt Deshayes;Heidi Ackerly;Maria Teresa Pisabarro

  • ICEBERG: a novel inhibitor of interleukin-1beta generation.

    Eric W Humke;Eric W Humke;Stephanie K Shriver;Melissa A Starovasnik;Wayne J Fairbrother

  • Expression profile of BCL-2, BCL-XL and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models

    Elizabeth A. Punnoose;Joel D. Leverson;Franklin Peale;Erwin R. Boghaert

  • Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

    Zhi-Fu Tao;Lisa Hasvold;Le Wang;Xilu Wang

  • Structure of C3b in complex with CRIg gives insights into regulation of complement activation

    Christian Wiesmann;Kenneth J. Katschke;JianPing Yin;Karim Y. Helmy

  • Souers AJ, Leverson JD, Boghaert ER et al.ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 19:202-208

    Andrew J. Souers;Joel D. Leverson;Erwin R. Boghaert;Scott L. Ackler

  • Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

    Jane Gitschier;Barbara Moffat;Dorothea Reilly;William I. Wood

  • Exploring protein-protein interactions with phage display.

    Sachdev S. Sidhu;Wayne J. Fairbrother;Kurt Deshayes

  • Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).

    John A. Flygare;Maureen Beresini;Nageshwar Budha;Helen Chan

  • The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

    Domagoj Vucic;Wayne J. Fairbrother

Frequent Co-Authors

Domagoj Vucic
Domagoj Vucic Genentech
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Jonathan B. Baell
Jonathan B. Baell Monash University
Peter M. Colman
Peter M. Colman Walter and Eliza Hall Institute of Medical Research
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Vishva M. Dixit
Vishva M. Dixit Genentech
Frederick Cohen
Frederick Cohen Nurix Therapeutics
Christian Wiesmann
Christian Wiesmann Novartis (Switzerland)

External Links

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Best Scientists Citing Wayne J. Fairbrother

Simone Fulda

Simone Fulda

Goethe University Frankfurt

Publications: 167

John Silke

John Silke

Walter and Eliza Hall Institute of Medical Research

Publications: 116

David C. S. Huang

David C. S. Huang

Walter and Eliza Hall Institute of Medical Research

Publications: 91

Andreas Strasser

Andreas Strasser

Walter and Eliza Hall Institute of Medical Research

Publications: 72

Andrew W. Roberts

Andrew W. Roberts

Walter and Eliza Hall Institute of Medical Research

Publications: 63

Guillaume Lessene

Guillaume Lessene

Walter and Eliza Hall Institute of Medical Research

Publications: 58

John F. Seymour

John F. Seymour

Peter MacCallum Cancer Centre

Publications: 55

Anthony Letai

Anthony Letai

Harvard University

Publications: 54

David L. Vaux

David L. Vaux

Walter and Eliza Hall Institute of Medical Research

Publications: 51

Domagoj Vucic

Domagoj Vucic

Genentech

Publications: 47

Peter Vandenabeele

Peter Vandenabeele

Ghent University

Publications: 45

John C. Reed

John C. Reed

Johnson & Johnson (United States)

Publications: 44

Peter E. Czabotar

Peter E. Czabotar

Walter and Eliza Hall Institute of Medical Research

Publications: 44

Henning Walczak

Henning Walczak

University College London

Publications: 37

Marco J. Herold

Marco J. Herold

Walter and Eliza Hall Institute of Medical Research

Publications: 34

Sachdev S. Sidhu

Sachdev S. Sidhu

University of Waterloo

Publications: 33

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