Christian Wiesmann

Overview

Best Publications

• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

  Ingrid E. Wertz;Karen M. O'Rourke;Honglin Zhou;Michael Eby

  2161
  Citations

• Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.

  Y. Chen;C. Wiesmann;G. Fuh;Bing Li

  1230
  Citations

• The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

  Adrian J. Folkes;Khatereh Ahmadi;Wendy K. Alderton;Sonia Alix

  1071
  Citations

• Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

  Christian Wiesmann;Germaine Fuh;Hans W. Christinger;Charles Eigenbrot

  666
  Citations

• Allosteric inhibition of protein tyrosine phosphatase 1B.

  Christian Wiesmann;Kenneth J Barr;Jenny Kung;Jiang Zhu

  590
  Citations

• Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

  C Wiesmann;M.H Ultsch;S.H Bass;A.M. de Vos

  547
  Citations

• The discovery of first-in-class drugs: origins and evolution.

  Joerg Eder;Richard Sedrani;Christian Wiesmann

  524
  Citations

• Anti-vegf antibodies

  Germaine Fuh;Hans-Peter Gerber;Wei-Ching Liang;Frederic A. Fellouse

  476
  Citations

• Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

  Jenny Bostrom;Shang-Fan Yu;David Kan;Brent A. Appleton

  446
  Citations

• High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.

  Frederic A. Fellouse;Kaori Esaki;Sara Birtalan;Demetrios Raptis

  436
  Citations

• Cryo-EM in drug discovery: achievements, limitations and prospects

  Jean-Paul Renaud;Ashwin Chari;Claudio Ciferri;Wen-Ti Liu

  424
  Citations

• Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition

  Frederic A. Fellouse;Christian Wiesmann;Sachdev S. Sidhu

  416
  Citations

• Macrophage complement receptors and pathogen clearance

  Menno van Lookeren Campagne;Christian Wiesmann;Eric J Brown

  395
  Citations

• Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

  Georgia Hatzivassiliou;Jacob R. Haling;Huifen Chen;Kyung Song

  333
  Citations

• Crystal structure of the HGF β‐chain in complex with the Sema domain of the Met receptor

  Jennifer Stamos;Robert A Lazarus;Xiaoyi Yao;Daniel Kirchhofer

  303
  Citations

• Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

  Jing Qing;Xiangnan Du;Yongmei Chen;Pamela Chan

  293
  Citations

• Nerve growth factor: structure and function.

  C Wiesmann;A M de Vos

  291
  Citations

• Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

  Daniel P. Sutherlin;Linda Bao;Megan Berry;Georgette Castanedo

  290
  Citations

• Structure of C3b in complex with CRIg gives insights into regulation of complement activation

  Christian Wiesmann;Kenneth J. Katschke;JianPing Yin;Karim Y. Helmy

  286
  Citations

• Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains

  Pierre A. Barthelemy;Helga Raab;Brent A. Appleton;Christopher J. Bond

  262
  Citations