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Mark Ultsch

Mark Ultsch

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
18996
World Ranking
12937
National Ranking
5509

Overview

Mark Ultsch is affiliated with Genentech in the United States and has a research focus primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work includes significant contributions to Molecular Biology, Immunology, Neurology, Radiology, Nuclear Medicine and Imaging, and Surgery.

The scientist's research addresses various topics, notably Monoclonal and Polyclonal Antibodies Research, Cerebrovascular and Genetic Disorders, Lipoproteins and Cardiovascular Health, Computational Drug Discovery Methods, PI3K/AKT/mTOR Signaling in Cancer, Protein Degradation and Inhibitors, and Chronic Lymphocytic Leukemia Research.

Key publications by Mark Ultsch include the following:

  • Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα, 2022, Journal of Medicinal Chemistry
  • Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor, 2022, Journal of Medicinal Chemistry
  • Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members., 2020, PubMed
  • Design of Organo-Peptides As Bipartite PCSK9 Antagonists, 2020, ACS Chemical Biology
  • Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration, 2022, Nature Communications

Frequent coauthors collaborating with Mark Ultsch include:

  • Daniel Kirchhofer
  • Charles Eigenbrot
  • Jodie Pang
  • Hans E. Purkey
  • Laurent Salphati

Publications featuring Mark Ultsch's work have appeared most frequently in the following venues:

  • Journal of Medicinal Chemistry
  • Nature Communications
  • PubMed
  • ACS Chemical Biology
  • Communications Biology

Best Publications

  • Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

    AM de Vos;M Ultsch;AA Kossiakoff

  • Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

    BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin

  • Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

    E E Idusogie;L G Presta;H Gazzano-Santoro;K Totpal

  • The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

    Adrian J. Folkes;Khatereh Ahmadi;Wendy K. Alderton;Sonia Alix

  • Convergent solutions to binding at a protein-protein interface.

    Warren L. DeLano;Mark H. Ultsch;Abraham M. de;Vos

  • Engineered Antibodies with Increased Activity to Recruit Complement

    Esohe E. Idusogie;Pin Yee Wong;Leonard G. Presta;Helene Gazzano-Santoro

  • Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

    Honglin Zhou;Ingrid Wertz;Ingrid Wertz;Karen O'Rourke;Mark Ultsch

  • Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

    S.G. Hymowitz;H.W. Christinger;G. Fuh;M.H. Ultsch

  • Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

    C Wiesmann;M.H Ultsch;S.H Bass;A.M. de Vos

  • The X-ray structure of a growth hormone–prolactin receptor complex

    W Somers;M Ultsch;A M De Vos;A A Kossiakoff

  • Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

    T Clackson;M.H Ultsch;J.A Wells;A.M. de Vos

  • A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.

    S.G. Hymowitz;M.P. O'Connell;M.H. Ultsch;A. Hurst

  • Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

    Georgia Hatzivassiliou;Jacob R. Haling;Huifen Chen;Kyung Song

  • Peptide exosite inhibitors of factor VIIa as anticoagulants

    Mark S. Dennis;Charles Eigenbrot;Nicholas J. Skelton;Mark H. Ultsch

  • The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

    M J Eck;M Ultsch;E Rinderknecht;A M de Vos

  • Structural plasticity in a remodeled protein-protein interface

    Shane Atwell;Mark Ultsch;Mark Ultsch;Abraham M. De Vos;Abraham M. De Vos;James A. Wells;James A. Wells

  • Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.

    M H Ultsch;C Wiesmann;L C Simmons;J Henrich

  • The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.

    R Bott;M Ultsch;A Kossiakoff;T Graycar

  • Structural basis for high-affinity HER2 receptor binding by an engineered protein

    Charles Eigenbrot;Mark Ultsch;Anatoly Dubnovitsky;Lars Abrahmsén

  • Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

    Calliope A. Dendrou;Adrian Cortes;Adrian Cortes;Lydia Shipman;Hayley G. Evans

Frequent Co-Authors

James A. Wells
James A. Wells University of California, San Francisco
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Christian Wiesmann
Christian Wiesmann Novartis (Switzerland)
Nico Ghilardi
Nico Ghilardi Genentech
Germaine Fuh
Germaine Fuh Genentech

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