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Mark Ultsch

Mark Ultsch

Genentech
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
18996
World Ranking
12932
National Ranking
5507

Mark Ultsch publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Mark Ultsch sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 154 publications — 29th percentile

29% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Mark Ultsch D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Mark Ultsch sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 58 D-Index — 34th percentile

34% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Mark Ultsch is affiliated with Genentech in the United States and has a research focus primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work includes significant contributions to Molecular Biology, Immunology, Neurology, Radiology, Nuclear Medicine and Imaging, and Surgery.

The scientist's research addresses various topics, notably Monoclonal and Polyclonal Antibodies Research, Cerebrovascular and Genetic Disorders, Lipoproteins and Cardiovascular Health, Computational Drug Discovery Methods, PI3K/AKT/mTOR Signaling in Cancer, Protein Degradation and Inhibitors, and Chronic Lymphocytic Leukemia Research.

Key publications by Mark Ultsch include the following:

  • Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα, 2022, Journal of Medicinal Chemistry
  • Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor, 2022, Journal of Medicinal Chemistry
  • Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members., 2020, PubMed
  • Design of Organo-Peptides As Bipartite PCSK9 Antagonists, 2020, ACS Chemical Biology
  • Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration, 2022, Nature Communications

Frequent coauthors collaborating with Mark Ultsch include:

  • Daniel Kirchhofer
  • Charles Eigenbrot
  • Jodie Pang
  • Hans E. Purkey
  • Laurent Salphati

Publications featuring Mark Ultsch's work have appeared most frequently in the following venues:

  • Journal of Medicinal Chemistry
  • Nature Communications
  • PubMed
  • ACS Chemical Biology
  • Communications Biology

Best Publications

  • Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

    AM de Vos;M Ultsch;AA Kossiakoff

  • Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

    BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin

  • Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

    E E Idusogie;L G Presta;H Gazzano-Santoro;K Totpal

  • The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

    Adrian J. Folkes;Khatereh Ahmadi;Wendy K. Alderton;Sonia Alix

  • Convergent solutions to binding at a protein-protein interface.

    Warren L. DeLano;Mark H. Ultsch;Abraham M. de;Vos

  • Engineered Antibodies with Increased Activity to Recruit Complement

    Esohe E. Idusogie;Pin Yee Wong;Leonard G. Presta;Helene Gazzano-Santoro

  • Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

    Honglin Zhou;Ingrid Wertz;Ingrid Wertz;Karen O'Rourke;Mark Ultsch

  • Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

    S.G. Hymowitz;H.W. Christinger;G. Fuh;M.H. Ultsch

  • Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

    C Wiesmann;M.H Ultsch;S.H Bass;A.M. de Vos

  • The X-ray structure of a growth hormone–prolactin receptor complex

    W Somers;M Ultsch;A M De Vos;A A Kossiakoff

  • Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

    T Clackson;M.H Ultsch;J.A Wells;A.M. de Vos

  • A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.

    S.G. Hymowitz;M.P. O'Connell;M.H. Ultsch;A. Hurst

  • Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

    Georgia Hatzivassiliou;Jacob R. Haling;Huifen Chen;Kyung Song

  • Peptide exosite inhibitors of factor VIIa as anticoagulants

    Mark S. Dennis;Charles Eigenbrot;Nicholas J. Skelton;Mark H. Ultsch

  • The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

    M J Eck;M Ultsch;E Rinderknecht;A M de Vos

  • Structural plasticity in a remodeled protein-protein interface

    Shane Atwell;Mark Ultsch;Mark Ultsch;Abraham M. De Vos;Abraham M. De Vos;James A. Wells;James A. Wells

  • Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.

    M H Ultsch;C Wiesmann;L C Simmons;J Henrich

  • The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.

    R Bott;M Ultsch;A Kossiakoff;T Graycar

  • Structural basis for high-affinity HER2 receptor binding by an engineered protein

    Charles Eigenbrot;Mark Ultsch;Anatoly Dubnovitsky;Lars Abrahmsén

  • Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

    Calliope A. Dendrou;Adrian Cortes;Adrian Cortes;Lydia Shipman;Hayley G. Evans

Frequent Co-Authors

Charles Eigenbrot
Charles Eigenbrot Genentech
James A. Wells
James A. Wells University of California, San Francisco
Daniel Kirchhofer
Daniel Kirchhofer Genentech
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Nicholas J. Skelton
Nicholas J. Skelton Genentech
Christian Wiesmann
Christian Wiesmann Novartis (Switzerland)
Robert A. Lazarus
Robert A. Lazarus Genentech
Nico Ghilardi
Nico Ghilardi Genentech
Germaine Fuh
Germaine Fuh Genentech
Robert F. Kelley
Robert F. Kelley Genentech

External Links

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Best Scientists Citing Mark Ultsch

Stuart J. Frank

Stuart J. Frank

University of Alabama at Birmingham

Publications: 67

John J. Kopchick

John J. Kopchick

Ohio University

Publications: 52

James A. Wells

James A. Wells

University of California, San Francisco

Publications: 46

Daniel Kirchhofer

Daniel Kirchhofer

Genentech

Publications: 40

Michael J. Waters

Michael J. Waters

University of Queensland

Publications: 35

John R. Desjarlais

John R. Desjarlais

Pennsylvania State University

Publications: 34

Germaine Fuh

Germaine Fuh

Genentech

Publications: 34

Anthony A. Kossiakoff

Anthony A. Kossiakoff

University of Chicago

Publications: 34

Paul A. Kelly

Paul A. Kelly

Queen Mary University of London

Publications: 33

Paul W. H. I. Parren

Paul W. H. I. Parren

Leiden University Medical Center

Publications: 32

Angel F. Lopez

Angel F. Lopez

University of South Australia

Publications: 32

Arieh Gertler

Arieh Gertler

Hebrew University of Jerusalem

Publications: 31

Sachdev S. Sidhu

Sachdev S. Sidhu

University of Waterloo

Publications: 31

Vincent Goffin

Vincent Goffin

Université Paris Cité

Publications: 30

Ruth Nussinov

Ruth Nussinov

National Institutes of Health

Publications: 29

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K. Christopher Garcia

Stanford University

Publications: 28

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