Charles Eigenbrot

Overview

Best Publications

• Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.

  Jennifer Stamos;Mark X. Sliwkowski;Charles Eigenbrot

  1556
  Citations

• An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

  Antony W. Burgess;Hyun Soo Cho;Hyun Soo Cho;Charles Eigenbrot;Kathryn M. Ferguson

  1255
  Citations

• Diverse somatic mutation patterns and pathway alterations in human cancers

  Zhengyan Kan;Bijay S. Jaiswal;Jeremy Stinson;Vasantharajan Janakiraman

  1175
  Citations

• Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

  Ben-Quan Shen;Keyang Xu;Luna Liu;Helga Raab

  1025
  Citations

• Cysteine engineered antibodies and conjugates

  Charles W. Eigenbrot;Jagath Reddy Junutula;Henry Lowman;Helga E. Raab

  728
  Citations

• Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

  Christian Wiesmann;Germaine Fuh;Hans W. Christinger;Charles Eigenbrot

  666
  Citations

• High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.

  Chingwei V Lee;Wei-Ching Liang;Mark S Dennis;Charles Eigenbrot

  628
  Citations

• Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer Therapeutics Trastuzumab and Geldanamycin

  Cary D. Austin;Ann M. De Mazière;Paul I. Pisacane;Suzanne M. van Dijk

  570
  Citations

• Oncogenic ERBB3 Mutations in Human Cancers

  Bijay S Jaiswal;Noelyn M Kljavin;Eric W Stawiski;Emily Chan

  388
  Citations

• A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.

  Gabriele Schaefer;Lauric J. Haber;Lisa M. Crocker;Steven Shia

  370
  Citations

• X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.

  Charles Eigenbrot;Michael Randal;Leonard Presta;Paul Carter

  354
  Citations

• Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.

  Sachdev S. Sidhu;Bing Li;Yvonne Chen;Frederic A. Fellouse

  310
  Citations

• Peptide exosite inhibitors of factor VIIa as anticoagulants

  Mark S. Dennis;Charles Eigenbrot;Nicholas J. Skelton;Mark H. Ultsch

  295
  Citations

• IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.

  Guohua Pan;Phillip Risser;Weiguang Mao;Daryl T. Baldwin

  279
  Citations

• Cyclic RGD peptide analogues as antiplatelet antithrombotics.

  P L Barker;S Bullens;S Bunting;D J Burdick

  278
  Citations

• Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

  James J. Crawford;Adam R. Johnson;Dinah L. Misner;Lisa D. Belmont

  252
  Citations

• Structural basis for high-affinity HER2 receptor binding by an engineered protein

  Charles Eigenbrot;Mark Ultsch;Anatoly Dubnovitsky;Lars Abrahmsén

  231
  Citations

• Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

  Calliope A. Dendrou;Adrian Cortes;Adrian Cortes;Lydia Shipman;Hayley G. Evans

  227
  Citations

• X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding

  Charles Eigenbrot;Nancy Gerber

  220
  Citations

• Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

  Aaron Boudreau;Hans E. Purkey;Anna Hitz;Kirk Robarge

  218
  Citations