Robert A. Lazarus

Overview

Best Publications

• Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.

  Mark S. Dennis;William J. Henzel;Robert M. Pitti;Michael T. Lipari

  416
  Citations

• Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist

  Marc Adler;Robert A. Lazarus;Mark S. Dennis;Gerhard Wagner

  347
  Citations

• Crystal structure of the HGF β‐chain in complex with the Sema domain of the Met receptor

  Jennifer Stamos;Robert A Lazarus;Xiaoyi Yao;Daniel Kirchhofer

  303
  Citations

• Peptide exosite inhibitors of factor VIIa as anticoagulants

  Mark S. Dennis;Charles Eigenbrot;Nicholas J. Skelton;Mark H. Ultsch

  295
  Citations

• A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

  Jasvinder K. Atwal;Yongmei Chen;Cecilia Chiu;Deborah L. Mortensen

  281
  Citations

• Production of 2-Keto-L-Gulonate, an Intermediate in L-Ascorbate Synthesis, by a Genetically Modified Erwinia herbicola

  Stephen Anderson;Cara Berman Marks;Robert Lazarus;Jeffrey Miller

  273
  Citations

• Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

  Mark Merchant;Xiaolei Ma;Henry R. Maun;Zhong Zheng

  267
  Citations

• Interactions between Hedgehog proteins and their binding partners come into view.

  Philip A. Beachy;Sarah G. Hymowitz;Robert A. Lazarus;Daniel J. Leahy

  254
  Citations

• Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display.

  M S Dennis;R A Lazarus

  186
  Citations

• Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting.

  Andrzej M. Krezel;Gerhard Wagner;Jana Seymour-Ulmer;Robert A. Lazarus

  186
  Citations

• Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1.

  Daniel Kirchhofer;Mark Peek;Wei Li;Jennifer Stamos

  168
  Citations

• Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

  Henry R. Maun;Xiaohui Wen;Andreas Lingel;Frederic J. de Sauvage

  159
  Citations

• The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

  Ivan Bosanac;Henry R Maun;Suzie J Scales;Xiaohui Wen

  156
  Citations

• Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins.

  Robert S. McDowell;Mark S. Dennis;Andrea Louie;Michael Shuster

  155
  Citations

• Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism

  Mark Merchant;Felix F. Vajdos;Mark Ultsch;Henry R. Maun;Henry R. Maun

  153
  Citations

• Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata.

  Paul Mazur;William J. Henzel;Jana L. Seymour;Robert A. Lazarus

  145
  Citations

• Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling

  Daniel Kirchhofer;Xiaoyi Yao;Mark Peek;Charles Eigenbrot

  139
  Citations

• Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding.

  Robert F. Kelley;Kimberly E. Costas;Mark P. O'Connell;Robert A. Lazarus

  134
  Citations

• Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection.

  M S Dennis;R A Lazarus

  128
  Citations

• The factor VII zymogen structure reveals reregistration of beta strands during activation.

  Charles Eigenbrot;Daniel Kirchhofer;Mark S. Dennis;Lydia Santell

  126
  Citations