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Biology and Biochemistry

D-Index
51
Citations
8776
World Ranking
17228
National Ranking
7090

Overview

Francis S. Markland is affiliated with the University of Southern California in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine. The scientist's work frequently touches on subjects related to venomous animal envenomation, cell adhesion molecules, and prostate cancer treatment.

Their scholarly output includes publications in peer-reviewed journals such as Biochemical Pharmacology and Cancer Research. Two notable recent papers are:

  • Preclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review (2020, Biochemical Pharmacology)
  • Abstract PO030: A novel integrin-targeted therapeutic agent for prostate cancer (2021, Cancer Research)

Markland's research interests encompass a diverse set of topics, including:

  • Venomous Animal Envenomation and Studies
  • Cell Adhesion Molecules Research
  • Bioactive Natural Diterpenoids Research
  • Immunotherapy and Immune Responses
  • Prostate Cancer Treatment and Research
  • Biochemical and Structural Characterization
  • Marine Sponges and Natural Products

Their main fields of study are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, Markland has contributed to subfields such as:

  • Genetics
  • Immunology and Allergy
  • Molecular Biology
  • Immunology
  • Pulmonary and Respiratory Medicine

Collaboration appears central to their research, with frequent co-authors including Stephen D. Swenson, Axel H. Schönthal, Thomas C. Chen, Radu O. Minea, and Jacek Pinski. These partnerships reflect interdisciplinary engagement across molecular biology and medical research domains.

Best Publications

  • Snake venoms and the hemostatic system

    Francis S. Markland

  • Phase II Clinical Trial of Bevacizumab and Low-Dose Metronomic Oral Cyclophosphamide in Recurrent Ovarian Cancer: A Trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia

    Agustin A. Garcia;Hal Hirte;Gini Fleming;Dongyun Yang

  • Snake venom metalloproteinases.

    Francis S. Markland;Stephen Swenson

  • Snake venom fibrin(ogen)olytic enzymes.

    S. Swenson;F.S. Markland

  • Subtilisin Carlsberg. V. The complete sequence; comparison with subtilisin BPN'; evolutionary relationships.

    E. L. Smith;R. J. Delange;William Howard Evans;M. Landon

  • Purification and properties of a thrombin-like enzyme from the venom of Crotalus adamanteus (Eastern diamondback rattlesnake).

    Francis S. Markland;Paul S. Damus

  • 16 Subtilisins: Primary Structure, Chemical and Physical Properties

    Francis S. Markland;Emil L. Smith

  • Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.

    Dezheng Dong;Bryce Ko;Peter Baumeister;Steven Swenson

  • Subtilisin BPN': VII. ISOLATION OF CYANOGEN BROMIDE PEPTIDES AND THE COMPLETE AMINO ACID SEQUENCE

    Francis S. Markland;Emil L. Smith

  • The Complete Amino Acid Sequence of Two Types of Subtilisin, BPN' and Carlsberg

    Emil L. Smith;Francis S. Markland;Charles B. Kasper;Robert J. Delange

  • Snake Venom Fibrinogenolytic and Fibrinolytic Enzymes: An Updated Inventory On behalf of the Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

    Francis Markland

  • Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression

    Qing Zhou;Russel P. Sherwin;Catherine Parrish;Valda Richters

  • Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression

    Stephen Swenson;Fritz Costa;Radu Minea;Russell P. Sherwin

  • Amino acid sequence of fibrolase, a direct‐acting fibrinolytic enzyme from agkistrodon contortrix contortrix venom

    Anne Randolph;Scott H. Chamberlain;H.-L. Cathy Chu;Frank R. Masiarz

  • Inventory of α- and β-fibrinogenases from snake venoms : for the subcommittee on nomenclature of exogenous hemostatic factors of the scientific and standardization committee of the international society on thrombosis and haemostasis

    Francis S Markland

  • Action of metalloproteinases mutalysin I and II on several components of the hemostatic and fibrinolytic systems.

    Maria I. Estêvão-Costa;Carlos R. Diniz;Arinos Magalhães;Francis S. Markland

  • Hemostasis and animal venoms

    Hubert Pirkle;Francis S. Markland

  • Fibrinolytic enzyme(s) in western diamondback rattlesnake (Crotalus atrox) venom

    S.S. Bajwa;Francis S. Markland;Findlay E. Russell

  • A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model.

    Francis S. Markland;Kate Shieh;Qing Zhou;Vladislav Golubkov

  • Proteolytic cleavage of the beta1 subunit of platelet alpha2beta1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72.

    A S Kamiguti;F S Markland;Q Zhou;Gavin D Laing

Frequent Co-Authors

Benedict R. Lucchesi
Benedict R. Lucchesi University of Michigan–Ann Arbor
Axel H. Schönthal
Axel H. Schönthal University of Southern California
Robert Bau
Robert Bau University of Southern California
Alan L. Epstein
Alan L. Epstein University of Southern California
Cassian Bon
Cassian Bon Institut Pasteur
R. Manjunatha Kini
R. Manjunatha Kini National University of Singapore
Russolina B. Zingali
Russolina B. Zingali Federal University of Rio de Janeiro
Alessandro Weisz
Alessandro Weisz University of Salerno
Kenneth J. Clemetson
Kenneth J. Clemetson University of Bern
Susan Groshen
Susan Groshen University of Southern California

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