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Sundeep Khosla

Sundeep Khosla

D-Index & Metrics

Medicine

D-Index
151
Citations
95799
World Ranking
1110
National Ranking
639

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Sundeep Khosla is affiliated with the Mayo Clinic in the United States and is active in research areas spanning medicine and biochemistry, genetics, and molecular biology. Their work encompasses various subfields, including physiology, orthopedics and sports medicine, molecular biology, surgery, and immunology.

Their research focuses on topics related to telomeres, telomerase, and senescence; bone health and osteoporosis; hip and femur fractures; bone metabolism and diseases; neutrophil, myeloperoxidase, and oxidative mechanisms; bone health and treatments; as well as mesenchymal stem cell research. These areas represent the breadth of their scientific inquiry into aging, bone-related disorders, and cellular mechanisms.

Recent publications authored or co-authored by Sundeep Khosla have appeared in leading journals such as Nature Reviews Endocrinology, Nature Communications, Nature, Science, and The Annual Review of Pharmacology and Toxicology. Significant papers include:

  • "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues" (2022, Nature Communications)
  • "The role of cellular senescence in ageing and endocrine disease" (2020, Nature Reviews Endocrinology)
  • "Apoptotic stress causes mtDNA release during senescence and drives the SASP" (2023, Nature)
  • "Senolytics reduce coronavirus-related mortality in old mice" (2021, Science)
  • "Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span" (2020, The Annual Review of Pharmacology and Toxicology)

Khosla's frequent collaborators include Joshua N. Farr, David G. Monroe, Nathan K. LeBrasseur, Elizabeth J. Atkinson, and Madison L. Doolittle, suggesting a robust interdisciplinary network in their research endeavors.

Their work has been published repeatedly in venues such as the Journal of Bone and Mineral Research, bioRxiv (Cold Spring Harbor Laboratory), the Journal of the Endocrine Society, Aging Cell, and Osteoporosis International.

Khosla has been recognized as a member of the Association of American Physicians, indicating professional engagement and acknowledgment within the medical research community.

Best Publications

  • Osteoporosis: now and the future

    Tilman D Rachner;Sundeep Khosla;Lorenz C Hofbauer

  • Sex steroids and the construction and conservation of the adult skeleton.

    B. Lawrence Riggs;Sundeep Khosla;L. Joseph Melton

  • Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research

    Sundeep Khosla;David Burr;Jane Cauley;David W. Dempster

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Minireview: The OPG/RANKL/RANK system

    Sundeep Khosla

  • Bisphosphonates: Mechanism of Action and Role in Clinical Practice

    Matthew T. Drake;Bart L. Clarke;Sundeep Khosla

  • Senolytics improve physical function and increase lifespan in old age

    Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand

  • The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.

    L C Hofbauer;S Khosla;C R Dunstan;D L Lacey

  • A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men

    B. Lawrence Riggs;Sundeep Khosla;L. Joseph Melton

  • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen

    Sundeep Khosla;L. Joseph Melton;Elizabeth J. Atkinson;W. M. O'Fallon

  • Fat tissue, aging, and cellular senescence

    Tamara Tchkonia;Dean E. Morbeck;Thomas Von Zglinicki;Jan Van Deursen

  • Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis.

    L C Hofbauer;F Gori;B L Riggs;D L Lacey

  • Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

    Ann E. Kearns;Sundeep Khosla;Paul J. Kostenuik

  • Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes.

    Thierry Thomas;Francesca Gori;Sundeep Khosla;Michael D. Jensen

  • Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites.

    B Lawrence Riggs;L Joseph Melton;Richard A Robb;Jon J Camp

  • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

    Guitty Eghbali-Fatourechi;Sundeep Khosla;Arunik Sanyal;William J. Boyle

  • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells.

    Lorenz C. Hofbauer;Sundeep Khosla;Colin R. Dunstan;David L. Lacey

  • Osteoporosis in Men

    Sundeep Khosla;Shreyasee Amin;Eric Orwoll

  • Targeting cellular senescence prevents age-related bone loss in mice

    Joshua N Farr;Ming Xu;Megan M Weivoda;David G Monroe

  • Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

    La Tonya J. Hickson;Larissa G.P. Langhi Prata;Shane A. Bobart;Tamara K. Evans

Frequent Co-Authors

L. Joseph Melton
L. Joseph Melton Mayo Clinic
Amir Lerman
Amir Lerman Mayo Clinic
Mary L. Bouxsein
Mary L. Bouxsein Beth Israel Deaconess Medical Center
Clifford J. Rosen
Clifford J. Rosen Maine Medical Center
Ann L. Oberg
Ann L. Oberg Mayo Clinic
Lilach O. Lerman
Lilach O. Lerman Mayo Clinic

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