Thomas C. Spelsberg mainly investigates Internal medicine, Endocrinology, Osteoblast, Estrogen receptor and Molecular biology. His Endocrinology research is multidisciplinary, incorporating perspectives in Cell culture, Osteoprotegerin and Stromal cell. The Osteoblast study combines topics in areas such as Osteocalcin, Transforming growth factor, Cellular differentiation and Bone marrow.
His Estrogen receptor research incorporates elements of Receptor and Tartrate-resistant acid phosphatase. Thomas C. Spelsberg combines subjects such as Cell nucleus and Bone cell with his study of Receptor. His Molecular biology research integrates issues from Transforming growth factor beta and Transcription factor, Zinc finger.
Thomas C. Spelsberg mainly focuses on Internal medicine, Endocrinology, Molecular biology, Receptor and Osteoblast. In his research on the topic of Internal medicine, Messenger RNA is strongly related with Gene expression. His work deals with themes such as Cell culture, Osteoclast and Stromal cell, which intersect with Endocrinology.
The study incorporates disciplines such as Regulation of gene expression, Transcription factor, Gene, Cell biology and Transforming growth factor beta in addition to Molecular biology. Thomas C. Spelsberg has included themes like Progesterone receptor, Hormone, Androgen, Steroid and Cell nucleus in his Receptor study. The concepts of his Osteoblast study are interwoven with issues in Cell, Cellular differentiation, Osteopontin, Northern blot and Osteonectin.
Internal medicine, Endocrinology, Osteoblast, Molecular biology and Cancer research are his primary areas of study. His study looks at the intersection of Internal medicine and topics like Cardiology with Autopsy. His work carried out in the field of Endocrinology brings together such families of science as Osteoclast and Estrogen receptor.
His Osteoblast study combines topics from a wide range of disciplines, such as Cell culture, Bone cell, Osteopontin, Pathology and Transforming growth factor beta. His Molecular biology research includes themes of Immunohistochemistry, Chromatin immunoprecipitation, Downregulation and upregulation, Cell biology and Regulation of gene expression. His Cancer research research is multidisciplinary, relying on both Cellular differentiation, Transcription factor, Immunology, Bone marrow and Signal transduction.
Thomas C. Spelsberg focuses on Internal medicine, Endocrinology, Osteoblast, Molecular biology and Estrogen receptor. His Internal medicine research includes elements of Cellular differentiation and Oncology. His research in Endocrinology intersects with topics in Knockout mouse and Aortic valve calcification.
His Osteoblast research incorporates themes from Cell culture, Osteopontin, Pathology and Osteocalcin, Alkaline phosphatase. The various areas that Thomas C. Spelsberg examines in his Molecular biology study include Promoter, ETS1, Gene expression, Transcriptional regulation and Cell biology. The various areas that he examines in his Estrogen receptor study include Regulation of gene expression and Estrogen.
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Evidence of estrogen receptors in normal human osteoblast-like cells
EF Eriksen;DS Colvard;NJ Berg;ML Graham.
Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis.
L C Hofbauer;F Gori;B L Riggs;D L Lacey.
Skeletal Effects of Estrogen
Russell T. Turner;B. Lawrence Riggs;Thomas C. Spelsberg.
Endocrine Reviews (1994)
Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype
Nalini M. Rajamannan;Malayannan Subramaniam;David Rickard;Stuart R. Stock.
Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells.
Lorenz C. Hofbauer;Sundeep Khosla;Colin R. Dunstan;David L. Lacey.
Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
L.C Hofbauer;D.L Lacey;C.R Dunstan;T.C Spelsberg.
Development and characterization of a conditionally immortalized human fetal osteoblastic cell line.
S A Harris;R J Enger;B L Riggs;T C Spelsberg.
Journal of Bone and Mineral Research (2009)
Nonhistone Chromosomal Proteins and Gene Regulation
Gary S. Stein;Thomas C. Spelsberg;Lewis J. Kleinsmith.
Identification of androgen receptors in normal human osteoblast-like cells
D S Colvard;E F Eriksen;P E Keeting;E M Wilson.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.
Gregory G. Reinholz;Barbara Getz;Larry Pederson;Emily S. Sanders.
Cancer Research (2000)
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