World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
46
Citations
10275
World Ranking
2797
National Ranking
1342

Overview

Frédéric Chédin is affiliated with the University of California, Davis, in the United States. Their research primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with a strong emphasis on Molecular Biology as a subfield. Additional subfields include Genetics, Plant Science, Epidemiology, and Immunology.

Their scientific work addresses several key topics within molecular biology and genetics, with concentration on:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation

Chédin has published extensively in various scientific venues. The most frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • eLife
  • Nucleic Acids Research
  • The Journal of Cell Biology

Recent representative publications by Frédéric Chédin include:

  • "Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites," 2020, Nature Communications
  • "Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids," 2021, The Journal of Cell Biology
  • "Defining R-loop classes and their contributions to genome instability," 2021, DNA Repair
  • "Emerging roles for R-loop structures in the management of topological stress," 2020, Journal of Biological Chemistry
  • "CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells," 2021, Cancer Discovery

Collaboration is a notable feature of their career, with frequent coauthors including:

  • Stella R. Hartono
  • Lionel A. Sanz
  • Daisy Castillo-Guzman
  • Shanaya Shital Shah
  • Wolf-Dietrich Heyer

Best Publications

  • R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

    Paul A. Ginno;Paul L. Lott;Holly C. Christensen;Ian F Korf

  • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

    Kefei Yu;Frederic Chedin;Chih Lin Hsieh;Thomas E. Wilson

  • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

    Frédéric Chédin;Michael R. Lieber;Chih-Lin Hsieh

  • Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-kappaB signaling

    Johnathon D. Anderson;Henrik J. Johansson;Calvin S. Graham;Mattias Vesterlund

  • Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

    Lionel A. Sanz;Stella R. Hartono;Yoong Wearn Lim;Sandra Steyaert

  • GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination

    Paul A Ginno;Yoong Wearn Lim;Paul L Lott;Ian F Korf

  • Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

    Caroline Townsend Stork;Michael Bocek;Madzia P Crossley;Julie Sollier

  • Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family

    Zhao Xia Chen;Jeffrey R. Mann;Chih Lin Hsieh;Arthur D. Riggs

  • Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R-loop accumulation

    Yanzhong Yang;Kevin M. McBride;Sean Hensley;Yue Lu

  • Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L.

    Michael S. Kareta;Zaida M. Botello;Joshua J. Ennis;Christina Chou

  • Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein

    Nataliya Nady;Alexander Lemak;John R. Walker;George V. Avvakumov

  • The DNMT3 family of mammalian de novo DNA methyltransferases.

    Frédéric Chédin

  • Transcription-associated R-loop formation across the human FMR1 CGG-repeat region.

    Erick W. Loomis;Lionel A. Sanz;Frédéric Chédin;Paul J. Hagerman

  • Nascent Connections: R-Loops and Chromatin Patterning

    Frédéric Chédin

  • High-resolution, strand-specific R-loop mapping via S9.6-based DNA–RNA immunoprecipitation and high-throughput sequencing

    Lionel A. Sanz;Frédéric Chédin

  • Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome

    Yoong Wearn Lim;Lionel A Sanz;Xiaoqin Xu;Stella R Hartono

  • R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation

    Weston T. Powell;Rochelle L. Coulson;Michael L. Gonzales;Florence K. Crary

  • DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.

    Bethany L. Wienholz;Michael S. Kareta;Amir H. Moarefi;Catherine A. Gordon

  • Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.

    Xiaowen Zhang;Huai Chin Chiang;Yao Wang;Chi Zhang

  • The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast.

    Stella R. Hartono;Amélie Malapert;Pénélope Legros;Pascal Bernard

Frequent Co-Authors

Stephen C. Kowalczykowski
Stephen C. Kowalczykowski University of California, Davis
Wolf Dietrich Heyer
Wolf Dietrich Heyer University of California, Davis
S. Dusko Ehrlich
S. Dusko Ehrlich University College London
Karlene A. Cimprich
Karlene A. Cimprich Stanford University
Sirano Dhe-Paganon
Sirano Dhe-Paganon Harvard University
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Chih-Lin Hsieh
Chih-Lin Hsieh University of Southern California
Ian F Korf
Ian F Korf University of California, Davis
Bin Tian
Bin Tian The Wistar Institute
Victor X. Jin
Victor X. Jin Medical College of Wisconsin

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